ID   MIH_CANPG               Reviewed;          78 AA.
AC   P55846;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Molt-inhibiting hormone;
DE            Short=MIH;
OS   Cancer pagurus (Rock crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC   Eubrachyura; Cancroidea; Cancridae; Cancer.
OX   NCBI_TaxID=6755;
RN   [1]
RP   PROTEIN SEQUENCE, AND MASS SPECTROMETRY.
RC   TISSUE=Sinus gland;
RX   PubMed=8868306; DOI=10.1016/s0143-4179(96)90061-x;
RA   Chung J.S., Wilkinson M.C., Webster S.G.;
RT   "Determination of the amino acid sequence of the moult-inhibiting hormone
RT   from the edible crab, Cancer pagurus.";
RL   Neuropeptides 30:95-101(1996).
CC   -!- FUNCTION: Inhibits Y-organs where molting hormone (ecdysteroid) is
CC       secreted. A molting cycle is initiated when MIH secretion diminishes or
CC       stops. Has also significant hyperglycemic hormone (CHH) activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=9193.3; Mass_error=0.53; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:8868306};
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P55846; -.
DR   SMR; P55846; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR001262; Hyperglycemic2.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00549; HYPRGLYCEMC2.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Neuropeptide; Secreted.
FT   CHAIN           1..78
FT                   /note="Molt-inhibiting hormone"
FT                   /id="PRO_0000209862"
FT   DISULFID        7..44
FT                   /evidence="ECO:0000250"
FT   DISULFID        24..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        27..53
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  9200 MW;  7285FB5FC8BA98C6 CRC64;
     RVINDDCPNL IGNRDLYKKV EWICEDCSNI FRNTGMATLC RKNCFFNEDF LWCVYATERT
     EEMSQLRQWV GILGAGRE