MIH_CHAFE
ID MIH_CHAFE Reviewed; 113 AA.
AC O96605;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Molt-inhibiting hormone;
DE Short=MIH;
DE Flags: Precursor;
GN Name=MIH;
OS Charybdis feriata (Crucifix crab) (Cancer feriatus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC Eubrachyura; Portunoidea; Portunidae; Charybdis.
OX NCBI_TaxID=65693;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9931416; DOI=10.1016/s0378-1119(98)00517-4;
RA Chan S.-M., Chen X.-G., Gu P.-L.;
RT "PCR cloning and expression of the molt-inhibiting hormone gene for the
RT crab (Charybdis feriatus).";
RL Gene 224:23-33(1998).
CC -!- FUNCTION: Inhibits Y-organs where molting hormone (ecdysteroid) is
CC secreted. A molting cycle is initiated when MIH secretion diminishes or
CC stops (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC {ECO:0000305}.
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DR EMBL; AF092945; AAC64785.1; -; Genomic_DNA.
DR AlphaFoldDB; O96605; -.
DR SMR; O96605; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.10.2010.10; -; 1.
DR InterPro; IPR018251; Crust_neurhormone_CS.
DR InterPro; IPR031098; Crust_neurohorm.
DR InterPro; IPR035957; Crust_neurohorm_sf.
DR InterPro; IPR001166; Hyperglycemic.
DR InterPro; IPR001262; Hyperglycemic2.
DR PANTHER; PTHR35981; PTHR35981; 1.
DR Pfam; PF01147; Crust_neurohorm; 1.
DR PRINTS; PR00549; HYPRGLYCEMC2.
DR PRINTS; PR00550; HYPRGLYCEMIC.
DR SUPFAM; SSF81778; SSF81778; 1.
DR PROSITE; PS01250; CHH_MIH_GIH; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Hormone; Neuropeptide; Secreted; Signal.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT PEPTIDE 36..113
FT /note="Molt-inhibiting hormone"
FT /id="PRO_0000019079"
FT DISULFID 42..79
FT /evidence="ECO:0000250"
FT DISULFID 59..75
FT /evidence="ECO:0000250"
FT DISULFID 62..88
FT /evidence="ECO:0000250"
SQ SEQUENCE 113 AA; 13160 MW; 5742578542DFC9A4 CRC64;
MMSRANSRFS CQRTWLLAVV VLAAIWSSSL HQAAARVFND DCPNLMGNRD LYKKVEWICD
DCANIFRIPG MASICRKDCF FNEDFLWCVR ATERTEEMMQ LKQWVRILGA GRM