ID   MIH_JASLA               Reviewed;          74 AA.
AC   P83220;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Probable molt-inhibiting hormone;
DE            Short=MIH;
OS   Jasus lalandii (South African spiny lobster).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Achelata;
OC   Palinuroidea; Palinuridae; Jasus.
OX   NCBI_TaxID=99572 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AND AMIDATION AT ALA-74.
RC   TISSUE=Sinus gland;
RX   PubMed=11072117; DOI=10.1016/s0196-9781(00)00273-4;
RA   Marco H.G., Stoeva S., Voelter W., Gaede G.;
RT   "Characterization and sequence elucidation of a novel peptide with molt-
RT   inhibiting activity from the South African spiny lobster, Jasus lalandii.";
RL   Peptides 21:1313-1321(2000).
CC   -!- FUNCTION: Inhibits Y-organs where molting hormone (ecdysteroid) is
CC       secreted. A molting cycle is initiated when MIH secretion diminishes or
CC       stops. Has little or no hyperglycemic activity.
CC       {ECO:0000269|PubMed:11072117}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=9007; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:11072117};
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P83220; -.
DR   SMR; P83220; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR001262; Hyperglycemic2.
DR   PANTHER; PTHR35981; PTHR35981; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00549; HYPRGLYCEMC2.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hormone;
KW   Neuropeptide; Secreted.
FT   CHAIN           1..74
FT                   /note="Probable molt-inhibiting hormone"
FT                   /id="PRO_0000209863"
FT   MOD_RES         74
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000269|PubMed:11072117"
FT   DISULFID        6..43
FT                   /evidence="ECO:0000250"
FT   DISULFID        23..39
FT                   /evidence="ECO:0000250"
FT   DISULFID        26..52
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   74 AA;  9013 MW;  8BCCF6EE7F195F49 CRC64;
     RFTFDCPGMM GQRYLYEQVE QVCDDCYNLY REEKIAVNCR ENCFLNSWFT VCLQATMREH
     ETPRFDIWRS ILKA