ID   MIH_METEN               Reviewed;         105 AA.
AC   O76534;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Probable molt-inhibiting hormone;
DE   AltName: Full=MEE-MIH;
DE   Flags: Precursor;
OS   Metapenaeus ensis (Greasyback shrimp) (Penaeus ensis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Metapenaeus.
OX   NCBI_TaxID=32278;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eyestalk;
RX   PubMed=9701616;
RA   Chan S.-M., Gu P.-L.;
RT   "Cloning of a cDNA encoding a putative molt-inhibiting hormone from the
RT   eyestalk of the sand shrimp Metapenaeus ensis.";
RL   Mol. Mar. Biol. Biotechnol. 7:214-220(1998).
CC   -!- FUNCTION: Inhibits Y-organs where molting hormone (ecdysteroid) is
CC       secreted. A molting cycle is initiated when MIH secretion diminishes or
CC       stops (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in the postmolt, intermolt, and premolt
CC       stages of the shrimp eyestalks and the brain.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   EMBL; AF076276; AAC27452.1; -; mRNA.
DR   AlphaFoldDB; O76534; -.
DR   SMR; O76534; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR001262; Hyperglycemic2.
DR   PANTHER; PTHR35981; PTHR35981; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00549; HYPRGLYCEMC2.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         29..105
FT                   /note="Probable molt-inhibiting hormone"
FT                   /id="PRO_0000019080"
FT   DISULFID        35..72
FT                   /evidence="ECO:0000250"
FT   DISULFID        52..68
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..81
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   105 AA;  12117 MW;  6931D21C8F707402 CRC64;
     MYRMPMRFWL TAVVMVVVGA LLLDTASASY IENTCRGVMG NRDIYKKVVR VCEDCTNIFR
     LPGLDGMCRD RCFNNEWFLV CLKAANRDDE LDKFKVWISI LNPGL