ID   MIH_METMG               Reviewed;         113 AA.
AC   O61389;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Molt-inhibiting hormone;
DE            Short=MIH;
DE   Flags: Precursor;
OS   Metacarcinus magister (Dungeness crab) (Cancer magister).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC   Eubrachyura; Cancroidea; Cancridae; Metacarcinus.
OX   NCBI_TaxID=29965;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eyestalk;
RX   PubMed=9548218; DOI=10.1016/s0303-7207(97)00226-8;
RA   Umphrey H.R., Lee K.J., Watson R.D., Spaziani E.;
RT   "Molecular cloning of a cDNA encoding molt-inhibiting hormone of the crab,
RT   Cancer magister.";
RL   Mol. Cell. Endocrinol. 136:145-149(1998).
CC   -!- FUNCTION: Inhibits Y-organs where molting hormone (ecdysteroid) is
CC       secreted. A molting cycle is initiated when MIH secretion diminishes or
CC       stops (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   EMBL; AF031493; AAC38984.1; -; mRNA.
DR   AlphaFoldDB; O61389; -.
DR   SMR; O61389; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR001262; Hyperglycemic2.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00549; HYPRGLYCEMC2.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Hormone; Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         36..113
FT                   /note="Molt-inhibiting hormone"
FT                   /id="PRO_0000019077"
FT   DISULFID        42..79
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..75
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..88
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   113 AA;  13228 MW;  02D0AAB1A53838F1 CRC64;
     MMSRTESRYS SQRTWLLSMV VLAALWSISV QRATARVIND DCPNLIGNRD LYKRVEWICE
     DCSNIFRNTG MATLCRKNCF FNEDFLWCVY ATERTEEMSQ LRQWVGILGA GRE