ID   MIH_PENVA               Reviewed;         102 AA.
AC   P55322; Q26158;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Molt-inhibiting hormone-like;
DE            Short=MIH-like;
DE   Flags: Precursor; Fragment;
OS   Penaeus vannamei (Whiteleg shrimp) (Litopenaeus vannamei).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Penaeus.
OX   NCBI_TaxID=6689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eyestalk;
RX   PubMed=8055060;
RA   Sun P.S.;
RT   "Molecular cloning and sequence analysis of a cDNA encoding a molt-
RT   inhibiting hormone-like neuropeptide from the white shrimp Penaeus
RT   vannamei.";
RL   Mol. Mar. Biol. Biotechnol. 3:1-6(1994).
CC   -!- FUNCTION: Inhibits Y-organs where molting hormone (ecdysteroid) is
CC       secreted. A molting cycle is initiated when MIH secretion diminishes or
CC       stops (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   EMBL; S73824; AAC60516.1; -; mRNA.
DR   AlphaFoldDB; P55322; -.
DR   SMR; P55322; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR000346; Hyperglycemic1.
DR   PANTHER; PTHR35981; PTHR35981; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00548; HYPRGLYCEMC1.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Hormone; Neuropeptide; Secreted; Signal.
FT   SIGNAL          <1..30
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         31..102
FT                   /note="Molt-inhibiting hormone-like"
FT                   /id="PRO_0000019083"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        37..73
FT                   /evidence="ECO:0000250"
FT   DISULFID        53..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        56..82
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   102 AA;  11441 MW;  C87551D9A8E8220F CRC64;
     LEKLLSSSSS SSGSSSPLDA LGGDHSVNKR DTFDHSCKGI YDRELFRKLD RVCEDCYNVF
     REPKVATECK SNCFVNKRFN VCVADLRHDV SRFLKMANSA LS