ID   MIH_PROCL               Reviewed;          75 AA.
AC   P55848;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Molt-inhibiting hormone;
DE            Short=MIH;
OS   Procambarus clarkii (Red swamp crayfish).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Astacidea;
OC   Astacoidea; Cambaridae; Procambarus.
OX   NCBI_TaxID=6728;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT ALA-75.
RX   PubMed=8901124; DOI=10.1271/bbb.60.554;
RA   Nagasawa H., Yang W.J., Shimizu H., Aida K., Tsutsumi H., Terauchi A.,
RA   Sonobe H.;
RT   "Isolation and amino acid sequence of a molt-inhibiting hormone from the
RT   American crayfish, Procambarus clarkii.";
RL   Biosci. Biotechnol. Biochem. 60:554-556(1996).
CC   -!- FUNCTION: Inhibits Y-organs where molting hormone (ecdysteroid) is
CC       secreted. A molting cycle is initiated when MIH secretion diminishes or
CC       stops (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P55848; -.
DR   SMR; P55848; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR001262; Hyperglycemic2.
DR   PANTHER; PTHR35981; PTHR35981; 1.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00549; HYPRGLYCEMC2.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hormone;
KW   Neuropeptide; Secreted.
FT   CHAIN           1..75
FT                   /note="Molt-inhibiting hormone"
FT                   /id="PRO_0000209865"
FT   MOD_RES         75
FT                   /note="Alanine amide"
FT                   /evidence="ECO:0000269|PubMed:8901124"
FT   DISULFID        7..44
FT                   /evidence="ECO:0000250"
FT   DISULFID        24..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        27..53
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   75 AA;  8658 MW;  7A4942A7BB605D05 CRC64;
     RYVFEECPGV MGNRAVHGKV TRVCEDCYNV FRDTDVLAGC RKGCFSSEMF KLCLLAMERV
     EEFPDFKRWI GILNA