MIIP_MOUSE
ID MIIP_MOUSE Reviewed; 387 AA.
AC A2A7Y5; Q3UZ92; Q8CFZ8; Q8VD71;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Migration and invasion-inhibitory protein;
DE AltName: Full=Invasion-inhibitory protein 45;
DE Short=IIp45;
GN Name=Miip; Synonyms=D4Wsu114e, Iip45;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Liver, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Inhibits glioma cells invasion and down-regulates
CC adhesion- and motility-associated genes such as NFKB2 and ICAM1.
CC Exhibits opposing effects to IGFBP2 on cell invasion (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with IGFBP2. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A2A7Y5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2A7Y5-2; Sequence=VSP_032215;
CC -!- CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH17525.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH17525.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=AAH24069.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK133976; BAE21965.1; -; mRNA.
DR EMBL; AL607066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC017525; AAH17525.1; ALT_SEQ; mRNA.
DR EMBL; BC024069; AAH24069.1; ALT_INIT; mRNA.
DR CCDS; CCDS18923.2; -. [A2A7Y5-1]
DR CCDS; CCDS89855.1; -. [A2A7Y5-2]
DR RefSeq; NP_001020536.2; NM_001025365.2. [A2A7Y5-1]
DR RefSeq; XP_006539013.1; XM_006538950.3.
DR AlphaFoldDB; A2A7Y5; -.
DR BioGRID; 205712; 1.
DR STRING; 10090.ENSMUSP00000030886; -.
DR iPTMnet; A2A7Y5; -.
DR PhosphoSitePlus; A2A7Y5; -.
DR jPOST; A2A7Y5; -.
DR PaxDb; A2A7Y5; -.
DR PRIDE; A2A7Y5; -.
DR ProteomicsDB; 295911; -. [A2A7Y5-1]
DR ProteomicsDB; 295912; -. [A2A7Y5-2]
DR Antibodypedia; 28442; 120 antibodies from 21 providers.
DR DNASU; 28010; -.
DR Ensembl; ENSMUST00000030886; ENSMUSP00000030886; ENSMUSG00000029022. [A2A7Y5-1]
DR Ensembl; ENSMUST00000119975; ENSMUSP00000113897; ENSMUSG00000029022. [A2A7Y5-2]
DR Ensembl; ENSMUST00000172710; ENSMUSP00000134085; ENSMUSG00000029022. [A2A7Y5-1]
DR GeneID; 28010; -.
DR KEGG; mmu:28010; -.
DR UCSC; uc008vtd.2; mouse. [A2A7Y5-1]
DR UCSC; uc008vte.2; mouse. [A2A7Y5-2]
DR CTD; 60672; -.
DR MGI; MGI:106506; Miip.
DR VEuPathDB; HostDB:ENSMUSG00000029022; -.
DR eggNOG; ENOG502RZQ8; Eukaryota.
DR GeneTree; ENSGT00390000003768; -.
DR HOGENOM; CLU_061576_0_0_1; -.
DR InParanoid; A2A7Y5; -.
DR OMA; PHVPRQK; -.
DR OrthoDB; 1259790at2759; -.
DR PhylomeDB; A2A7Y5; -.
DR TreeFam; TF335829; -.
DR BioGRID-ORCS; 28010; 6 hits in 76 CRISPR screens.
DR PRO; PR:A2A7Y5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A2A7Y5; protein.
DR Bgee; ENSMUSG00000029022; Expressed in granulocyte and 203 other tissues.
DR ExpressionAtlas; A2A7Y5; baseline and differential.
DR Genevisible; A2A7Y5; MM.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:InterPro.
DR GO; GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; IEA:InterPro.
DR InterPro; IPR031466; MIIP.
DR PANTHER; PTHR34831; PTHR34831; 1.
DR Pfam; PF15734; MIIP; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..387
FT /note="Migration and invasion-inhibitory protein"
FT /id="PRO_0000324323"
FT REGION 50..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 307
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5JXC2"
FT VAR_SEQ 365..387
FT /note="ALPAQVTPPLWSEPQVAQLCPSH -> KPRGQTAQKTTVFYQCQQPPLRRSP
FT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032215"
SQ SEQUENCE 387 AA; 42828 MW; 62D3902428FF1F2C CRC64;
MPNMAETKDP VRLRLLSLEL LKQLWAGHEA MCRSVVRAAS GSNLDCSSNN LEMPLSQETS
SASSVAPSSQ DKRHMLDPLD SRRDDTFDVA WYVKFNSRMD SFLPATGQHQ EPQEELRPPS
VPLLATQGLK GPVSLGGPKG LGPDKTQVPR SILSRLSKPS KPRVTSQESA VPESSWHSRP
YLGYDWIAGS LDNSSPVTSE PEAFFSMLQR FRENNKEDCV CNSPEAVFPG LQESSGVEED
HECMYCYRIN RRLFPEPVDP GAPCRLCGIP RDEKGPGTLV EPVQVRVSIP LSIMDPPHQY
RIHRRKSFDA SDTLALPRHC LLGWDILPPK SEKTSVPKSL DLWSSVSYGA GQRRDLSATS
PPCQALPAQV TPPLWSEPQV AQLCPSH
