ID   MIIP_RAT                Reviewed;         389 AA.
AC   Q6AYH0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Migration and invasion-inhibitory protein;
DE   AltName: Full=Invasion-inhibitory protein 45;
DE            Short=IIp45;
GN   Name=Miip; Synonyms=Iip45;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-309, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: Inhibits glioma cells invasion and down-regulates
CC       adhesion- and motility-associated genes such as NFKB2 and ICAM1.
CC       Exhibits opposing effects to IGFBP2 on cell invasion (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with IGFBP2. {ECO:0000250}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH79047.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC079047; AAH79047.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001017450.1; NM_001017450.1.
DR   RefSeq; XP_006239441.1; XM_006239379.2.
DR   RefSeq; XP_006239442.1; XM_006239380.3.
DR   RefSeq; XP_006239443.1; XM_006239381.2.
DR   RefSeq; XP_006239468.1; XM_006239406.3.
DR   RefSeq; XP_006239469.1; XM_006239407.3.
DR   RefSeq; XP_006239470.1; XM_006239408.2.
DR   RefSeq; XP_006239471.1; XM_006239409.2.
DR   AlphaFoldDB; Q6AYH0; -.
DR   STRING; 10116.ENSRNOP00000032889; -.
DR   iPTMnet; Q6AYH0; -.
DR   PhosphoSitePlus; Q6AYH0; -.
DR   PaxDb; Q6AYH0; -.
DR   PRIDE; Q6AYH0; -.
DR   Ensembl; ENSRNOT00000035695; ENSRNOP00000032889; ENSRNOG00000024139.
DR   GeneID; 298643; -.
DR   KEGG; rno:298643; -.
DR   UCSC; RGD:1587376; rat.
DR   CTD; 60672; -.
DR   RGD; 1587376; Miip.
DR   eggNOG; ENOG502RZQ8; Eukaryota.
DR   GeneTree; ENSGT00390000003768; -.
DR   HOGENOM; CLU_061576_0_0_1; -.
DR   InParanoid; Q6AYH0; -.
DR   OMA; PHVPRQK; -.
DR   OrthoDB; 1259790at2759; -.
DR   PhylomeDB; Q6AYH0; -.
DR   TreeFam; TF335829; -.
DR   PRO; PR:Q6AYH0; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000024139; Expressed in testis and 19 other tissues.
DR   ExpressionAtlas; Q6AYH0; baseline.
DR   Genevisible; Q6AYH0; RN.
DR   GO; GO:0030336; P:negative regulation of cell migration; IEA:InterPro.
DR   GO; GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; IEA:InterPro.
DR   InterPro; IPR031466; MIIP.
DR   PANTHER; PTHR34831; PTHR34831; 1.
DR   Pfam; PF15734; MIIP; 1.
PE   1: Evidence at protein level;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..389
FT                   /note="Migration and invasion-inhibitory protein"
FT                   /id="PRO_0000324324"
FT   REGION          44..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          131..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         309
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   389 AA;  43339 MW;  22554C41CD16F785 CRC64;
     MTNMAETKDT VQLRLLSLEL LKQLWAGHEA MCQSVTRAAS ESNLDYSSSS NNLEMPLSQE
     TSASSVAPNS QDKRHVWDPL DSHRGDTYDV AWYGKVNSRV DSLPPATCQH QEPQEGLRPS
     SVPLLATEGL KRPVSLGGPK GLGPDKAQVP RSLPLRLGKL SKPKVTFSQE SSVPESSWYS
     RPCLDYDWTA GSLDSSSPVS SESEAYFSML QRFREDNRED CVCNSPEAVF PELQESSGVE
     EDHECVYCYR INRRLFPEPL DPGAPCCLCG IPRDEQGPQT LVEPVQVRVS IPLSIMDPPH
     QYRIHRRKSF DASDTFALPR HCLLGWDILP PKSEKTSVPK SLDLWSSVSH GAAQRRNLSA
     TNPSYQALRS RVPPPFWSEP QVARLCPSH