MIME_CHICK
ID MIME_CHICK Reviewed; 294 AA.
AC Q9W6H0;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Mimecan;
DE AltName: Full=Osteoglycin;
DE Flags: Precursor;
GN Name=OGN;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Cornea;
RX PubMed=10712821; DOI=10.1006/exer.1999.0789;
RA Dunlevy J.R., Beales M.P., Berryhill B.L., Cornuet P.K., Hassell J.R.;
RT "Expression of the keratan sulfate proteoglycans lumican, keratocan and
RT osteoglycin/mimecan during chick corneal development.";
RL Exp. Eye Res. 70:349-362(2000).
CC -!- FUNCTION: Induces bone formation in conjunction with TGF-beta-1 or TGF-
CC beta-2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Levels decrease at each developmental time point
CC and further decrease during maturation into adulthood.
CC -!- PTM: The composition of the N-linked chains or the substitution of the
CC N-linked sites is different between embryonic and adult tissues.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class III subfamily. {ECO:0000305}.
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DR EMBL; AF126963; AAD21085.1; -; mRNA.
DR RefSeq; NP_989540.1; NM_204209.1.
DR AlphaFoldDB; Q9W6H0; -.
DR SMR; Q9W6H0; -.
DR STRING; 9031.ENSGALP00000043060; -.
DR PaxDb; Q9W6H0; -.
DR Ensembl; ENSGALT00000045074; ENSGALP00000043060; ENSGALG00000026736.
DR Ensembl; ENSGALT00000078253; ENSGALP00000047361; ENSGALG00000026736.
DR GeneID; 374039; -.
DR KEGG; gga:374039; -.
DR CTD; 4969; -.
DR VEuPathDB; HostDB:geneid_374039; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157238; -.
DR HOGENOM; CLU_067583_1_0_1; -.
DR InParanoid; Q9W6H0; -.
DR OMA; RILHLQY; -.
DR OrthoDB; 927103at2759; -.
DR PhylomeDB; Q9W6H0; -.
DR TreeFam; TF351924; -.
DR Reactome; R-GGA-2022854; Keratan sulfate biosynthesis.
DR Reactome; R-GGA-2022857; Keratan sulfate degradation.
DR PRO; PR:Q9W6H0; -.
DR Proteomes; UP000000539; Chromosome 12.
DR Bgee; ENSGALG00000026736; Expressed in colon and 11 other tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0061975; P:articular cartilage development; IBA:GO_Central.
DR GO; GO:0060348; P:bone development; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027211; Mimecan.
DR InterPro; IPR043547; Mimecan/Epiphycan.
DR PANTHER; PTHR46269; PTHR46269; 1.
DR PANTHER; PTHR46269:SF1; PTHR46269:SF1; 1.
DR Pfam; PF13306; LRR_5; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Disulfide bond; Extracellular matrix; Glycoprotein; Growth factor;
KW Leucine-rich repeat; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..294
FT /note="Mimecan"
FT /id="PRO_0000032762"
FT REPEAT 108..127
FT /note="LRR 1"
FT REPEAT 128..151
FT /note="LRR 2"
FT REPEAT 152..175
FT /note="LRR 3"
FT REPEAT 176..195
FT /note="LRR 4"
FT REPEAT 196..221
FT /note="LRR 5"
FT REPEAT 222..242
FT /note="LRR 6"
FT REPEAT 243..273
FT /note="LRR 7"
FT CARBOHYD 61
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 241
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 254
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 251..284
FT /evidence="ECO:0000250"
SQ SEQUENCE 294 AA; 33179 MW; 0386701A28A7A6EF CRC64;
MKTLQAAFFL VAFVPLVKPA PPIQQDSPKF YEYVDADFAT GSLIQQDYEM LPKDTIKDGT
NVSLDTALRL QADDSELSAR PTKDTNLPTC LLCVCLSGSV YCEEIDIEAV PPLPKETAYL
YARFNKIKRI AVSDFADITT LRRIDFSGNM IEEIEDGAFS KLLLLEELSL AENRLVKLPV
LPPKLTTFNA NQNRIKSRGI KNNAFKKLTN LAYLYLGHNA LESVPLNLPE SLRILHLQHN
NITTINDDTF CKSNNTRYIR TRMDEIRMEG NPILLAKHVN AFSCLRTLPV GTYY
