MIME_MOUSE
ID MIME_MOUSE Reviewed; 298 AA.
AC Q62000;
DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Mimecan;
DE AltName: Full=Osteoglycin;
DE Flags: Precursor;
GN Name=Ogn; Synonyms=Og;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Limb bud;
RX PubMed=7607548; DOI=10.1016/0378-1119(95)00070-m;
RA Ujita M., Shinomura T., Kimata K.;
RT "Molecular cloning of the mouse osteoglycin-encoding gene.";
RL Gene 158:237-240(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Induces bone formation in conjunction with TGF-beta-1 or TGF-
CC beta-2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC family. SLRP class III subfamily. {ECO:0000305}.
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DR EMBL; D31951; BAA06721.1; -; mRNA.
DR EMBL; BC021939; AAH21939.1; -; mRNA.
DR CCDS; CCDS26505.1; -.
DR PIR; JC4130; JC4130.
DR RefSeq; NP_032786.1; NM_008760.4.
DR AlphaFoldDB; Q62000; -.
DR SMR; Q62000; -.
DR BioGRID; 201907; 1.
DR IntAct; Q62000; 15.
DR STRING; 10090.ENSMUSP00000021822; -.
DR GlyGen; Q62000; 1 site.
DR iPTMnet; Q62000; -.
DR PhosphoSitePlus; Q62000; -.
DR CPTAC; non-CPTAC-4048; -.
DR MaxQB; Q62000; -.
DR PaxDb; Q62000; -.
DR PeptideAtlas; Q62000; -.
DR PRIDE; Q62000; -.
DR ProteomicsDB; 295606; -.
DR Antibodypedia; 2122; 309 antibodies from 34 providers.
DR DNASU; 18295; -.
DR Ensembl; ENSMUST00000021822; ENSMUSP00000021822; ENSMUSG00000021390.
DR GeneID; 18295; -.
DR KEGG; mmu:18295; -.
DR UCSC; uc007qjr.1; mouse.
DR CTD; 4969; -.
DR MGI; MGI:109278; Ogn.
DR VEuPathDB; HostDB:ENSMUSG00000021390; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000157238; -.
DR HOGENOM; CLU_067583_1_0_1; -.
DR InParanoid; Q62000; -.
DR OMA; RILHLQY; -.
DR OrthoDB; 927103at2759; -.
DR PhylomeDB; Q62000; -.
DR TreeFam; TF351924; -.
DR Reactome; R-MMU-2022854; Keratan sulfate biosynthesis.
DR Reactome; R-MMU-2022857; Keratan sulfate degradation.
DR BioGRID-ORCS; 18295; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Ogn; mouse.
DR PRO; PR:Q62000; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q62000; protein.
DR Bgee; ENSMUSG00000021390; Expressed in aorta tunica media and 237 other tissues.
DR ExpressionAtlas; Q62000; baseline and differential.
DR Genevisible; Q62000; MM.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0061975; P:articular cartilage development; IBA:GO_Central.
DR GO; GO:0060348; P:bone development; IBA:GO_Central.
DR GO; GO:0048662; P:negative regulation of smooth muscle cell proliferation; ISO:MGI.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027211; Mimecan.
DR InterPro; IPR043547; Mimecan/Epiphycan.
DR PANTHER; PTHR46269; PTHR46269; 1.
DR PANTHER; PTHR46269:SF1; PTHR46269:SF1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR SMART; SM00369; LRR_TYP; 4.
DR PROSITE; PS51450; LRR; 4.
PE 1: Evidence at protein level;
KW Disulfide bond; Extracellular matrix; Glycoprotein; Growth factor;
KW Leucine-rich repeat; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..298
FT /note="Mimecan"
FT /id="PRO_0000032761"
FT REPEAT 112..131
FT /note="LRR 1"
FT REPEAT 132..155
FT /note="LRR 2"
FT REPEAT 156..179
FT /note="LRR 3"
FT REPEAT 180..199
FT /note="LRR 4"
FT REPEAT 200..225
FT /note="LRR 5"
FT REPEAT 226..246
FT /note="LRR 6"
FT REPEAT 247..277
FT /note="LRR 7"
FT CARBOHYD 258
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 255..288
FT /evidence="ECO:0000250"
SQ SEQUENCE 298 AA; 34012 MW; 0C5DB4A5AB6B05FE CRC64;
METVHSTFLL LLFVPLTQQA PQSQLDSHVN YEYATGNSEE TKFSQDYEDK YLDGKSIKEK
ETMIIPDEKS LQLQKDEVIP SLPTKKENDE MPTCLLCVCL SGSVYCEEVD IDAVPPLPKE
SAYLYARFNK IKKLTAKDFA DMPNLRRLDF TGNLIEDIED GTFSKLSLLE ELTLAENQLL
RLPVLPPKLT LLNAKHNKIK SKGIKANTFK KLNKLSFLYL DHNDLESVPP NLPESLRVIH
LQFNSISSLT DDTFCKANDT RYIRERIEEI RLEGNPIALG KHPNSFICLK RLPIGSYF
