ID   MIME_PONAB              Reviewed;         298 AA.
AC   Q5RBL2;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Mimecan;
DE   AltName: Full=Osteoglycin;
DE   Flags: Precursor;
GN   Name=OGN;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Induces bone formation in conjunction with TGF-beta-1 or TGF-
CC       beta-2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC       family. SLRP class III subfamily. {ECO:0000305}.
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DR   EMBL; CR858628; CAH90848.1; -; mRNA.
DR   RefSeq; NP_001125484.1; NM_001132012.1.
DR   AlphaFoldDB; Q5RBL2; -.
DR   SMR; Q5RBL2; -.
DR   STRING; 9601.ENSPPYP00000021715; -.
DR   PRIDE; Q5RBL2; -.
DR   Ensembl; ENSPPYT00000022602; ENSPPYP00000021715; ENSPPYG00000019377.
DR   GeneID; 100172393; -.
DR   KEGG; pon:100172393; -.
DR   CTD; 4969; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000157238; -.
DR   HOGENOM; CLU_067583_1_0_1; -.
DR   InParanoid; Q5RBL2; -.
DR   OMA; RILHLQY; -.
DR   OrthoDB; 927103at2759; -.
DR   TreeFam; TF351924; -.
DR   Proteomes; UP000001595; Chromosome 9.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027211; Mimecan.
DR   InterPro; IPR043547; Mimecan/Epiphycan.
DR   PANTHER; PTHR46269; PTHR46269; 1.
DR   PANTHER; PTHR46269:SF1; PTHR46269:SF1; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   PROSITE; PS51450; LRR; 4.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Extracellular matrix; Glycoprotein; Growth factor;
KW   Leucine-rich repeat; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..298
FT                   /note="Mimecan"
FT                   /id="PRO_0000240315"
FT   REPEAT          112..131
FT                   /note="LRR 1"
FT   REPEAT          132..155
FT                   /note="LRR 2"
FT   REPEAT          156..179
FT                   /note="LRR 3"
FT   REPEAT          180..199
FT                   /note="LRR 4"
FT   REPEAT          200..225
FT                   /note="LRR 5"
FT   REPEAT          226..246
FT                   /note="LRR 6"
FT   REPEAT          247..277
FT                   /note="LRR 7"
FT   CARBOHYD        214
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        258
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        255..288
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   298 AA;  33956 MW;  2F3F21C7A186178B CRC64;
     MKTLQSTLLL LLFVPLIKPA PPTQQDSRII YDYGTDNFEE SIFSQDYEDK YLDGKNIKEK
     ETVIIPNEKS LQLQKDEAIT PLPPKKENDE MPTCLLCVCL SGSVYCEEVD IDAVPPLPKE
     SAYLYARFNK IKKLTAKDFA DIPNLRRLDF TGNLIEDIED GTFSKLSLLE ELSLAENQLL
     KLPVLPPKLT LFNAKYNKIK SRGIKANAFK KLNNLTFLYL DHNALESVPL NLPESLRVIH
     LQFNNIASIT DDTFCKANDT SYIRDRIEEI RLEGNPIVLG KHPNSFICLK RLPIGSYF