ID   MIME_RABIT              Reviewed;         298 AA.
AC   Q8MJF1;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Mimecan;
DE   AltName: Full=Osteoglycin;
DE   Flags: Precursor;
GN   Name=OGN;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=12841336; DOI=10.1023/a:1023487424751;
RA   Fernandez B., Kampmann A., Pipp F., Zimmermann R., Schaper W.;
RT   "Osteoglycin expression and localization in rabbit tissues and
RT   atherosclerotic plaques.";
RL   Mol. Cell. Biochem. 246:3-11(2003).
CC   -!- FUNCTION: Induces bone formation in conjunction with TGF-beta-1 or TGF-
CC       beta-2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000269|PubMed:12841336}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in cardiac right ventricle,
CC       cardiac left ventricle, uterus and lung (at protein level). Detected at
CC       low levels in skeletal muscle, uterus, small intestine and liver (at
CC       protein level). Detected in blood vessels of kidney, pancreas, spleen
CC       and brain (at protein level). Detected in aorta and skeletal muscle.
CC       {ECO:0000269|PubMed:12841336}.
CC   -!- SIMILARITY: Belongs to the small leucine-rich proteoglycan (SLRP)
CC       family. SLRP class III subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF487889; AAM46865.1; -; mRNA.
DR   RefSeq; NP_001075585.1; NM_001082116.1.
DR   AlphaFoldDB; Q8MJF1; -.
DR   SMR; Q8MJF1; -.
DR   STRING; 9986.ENSOCUP00000007778; -.
DR   Ensembl; ENSOCUT00000009010; ENSOCUP00000007778; ENSOCUG00000009017.
DR   GeneID; 100008835; -.
DR   KEGG; ocu:100008835; -.
DR   CTD; 4969; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   GeneTree; ENSGT00940000157238; -.
DR   HOGENOM; CLU_067583_1_0_1; -.
DR   InParanoid; Q8MJF1; -.
DR   OMA; RILHLQY; -.
DR   OrthoDB; 927103at2759; -.
DR   TreeFam; TF351924; -.
DR   Proteomes; UP000001811; Chromosome 1.
DR   Bgee; ENSOCUG00000009017; Expressed in aorta and 16 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR027211; Mimecan.
DR   InterPro; IPR043547; Mimecan/Epiphycan.
DR   PANTHER; PTHR46269; PTHR46269; 1.
DR   PANTHER; PTHR46269:SF1; PTHR46269:SF1; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   SMART; SM00369; LRR_TYP; 4.
DR   PROSITE; PS51450; LRR; 4.
PE   1: Evidence at protein level;
KW   Disulfide bond; Extracellular matrix; Glycoprotein; Growth factor;
KW   Leucine-rich repeat; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..298
FT                   /note="Mimecan"
FT                   /id="PRO_0000240316"
FT   REPEAT          112..131
FT                   /note="LRR 1"
FT   REPEAT          132..155
FT                   /note="LRR 2"
FT   REPEAT          156..179
FT                   /note="LRR 3"
FT   REPEAT          180..199
FT                   /note="LRR 4"
FT   REPEAT          200..225
FT                   /note="LRR 5"
FT   REPEAT          226..246
FT                   /note="LRR 6"
FT   REPEAT          247..277
FT                   /note="LRR 7"
FT   CARBOHYD        214
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        258
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        255..288
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   298 AA;  33918 MW;  1B2F02450833AC7E CRC64;
     MKTLRSTLLL LLFVPLIKPA PPAPQESPLT FDYAADHLEE AIFSQDYEDK YLDGKNIEEK
     QTMVRSVKRS LELQKDESVT PAPPKKENDE MPTCLLCVCL SGSVYCEEVD IDAVPPLPKE
     SAYLYARFNK IKKLTAKDFA DMPNLRRLDF TGNLIEDIED GTFSKLALLE ELSLAENQLL
     KLPVLPPKLT LFNAKYNKIK SRGIKANTFK KLNNLSFLYL DHNALESVPP NLPESLRVIH
     LQFNNITSIT DDTFCKANDT RYIRDRIEEI RLEGNPIALG KHPNSFICLK RLPIGTYF