ID   MINC_CLOD6              Reviewed;         227 AA.
AC   Q18B13;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Probable septum site-determining protein MinC {ECO:0000255|HAMAP-Rule:MF_00267};
GN   Name=minC {ECO:0000255|HAMAP-Rule:MF_00267}; OrderedLocusNames=CD630_11490;
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630;
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- FUNCTION: Cell division inhibitor that blocks the formation of polar Z
CC       ring septums. Rapidly oscillates between the poles of the cell to
CC       destabilize FtsZ filaments that have formed before they mature into
CC       polar Z rings. Prevents FtsZ polymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00267}.
CC   -!- SUBUNIT: Interacts with MinD and FtsZ. {ECO:0000255|HAMAP-
CC       Rule:MF_00267}.
CC   -!- SIMILARITY: Belongs to the MinC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00267}.
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DR   EMBL; AM180355; CAJ68002.1; -; Genomic_DNA.
DR   RefSeq; WP_003428479.1; NZ_CP010905.2.
DR   RefSeq; YP_001087641.1; NC_009089.1.
DR   AlphaFoldDB; Q18B13; -.
DR   SMR; Q18B13; -.
DR   STRING; 272563.CD630_11490; -.
DR   EnsemblBacteria; CAJ68002; CAJ68002; CD630_11490.
DR   GeneID; 66353559; -.
DR   KEGG; cdf:CD630_11490; -.
DR   KEGG; pdc:CDIF630_01296; -.
DR   PATRIC; fig|272563.120.peg.1198; -.
DR   eggNOG; COG0850; Bacteria.
DR   OMA; EMECAYI; -.
DR   PhylomeDB; Q18B13; -.
DR   BioCyc; PDIF272563:G12WB-1279-MON; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0000902; P:cell morphogenesis; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:1901891; P:regulation of cell septum assembly; IEA:InterPro.
DR   Gene3D; 2.160.20.70; -; 2.
DR   HAMAP; MF_00267; MinC; 1.
DR   InterPro; IPR016098; CAP/MinC_C.
DR   InterPro; IPR013033; MinC.
DR   InterPro; IPR036145; MinC_C_sf.
DR   InterPro; IPR005526; Septum_form_inhib_MinC_C.
DR   PANTHER; PTHR34108; PTHR34108; 2.
DR   Pfam; PF03775; MinC_C; 1.
DR   SUPFAM; SSF63848; SSF63848; 2.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Reference proteome; Septation.
FT   CHAIN           1..227
FT                   /note="Probable septum site-determining protein MinC"
FT                   /id="PRO_1000191239"
SQ   SEQUENCE   227 AA;  25094 MW;  60E73818CF1D4544 CRC64;
     MSLREICSQE LVEFKGNKRG IIVNIKREAP FEEIQEKIIN KLEAYVGFFN GAKISKINSD
     CLTDMEILEL KEGITSRFDV EFVEDQKIEE NSNFPTKYVN TLRSGENIEF EGDVVILNDM
     KPGSKVLSKS NTVVMGDINA GAKVVAGGNV FVMGKIEGFV HAGAEGNEFA YVVAGNLNPK
     ILQIADNIAE APDDEENYES ESEISPEIAF VSNGRIVIES YLSKLDK