6PGL5_ARATH
ID 6PGL5_ARATH Reviewed; 252 AA.
AC Q8LEV7; Q9FIN0;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Probable 6-phosphogluconolactonase 5 {ECO:0000305};
DE Short=6PGL5 {ECO:0000305};
DE EC=3.1.1.31 {ECO:0000250|UniProtKB:Q84WW2};
GN Name=PGL5 {ECO:0000303|PubMed:19457984};
GN OrderedLocusNames=At5g24420 {ECO:0000312|Araport:AT5G24420};
GN ORFNames=K16H17.13 {ECO:0000312|EMBL:BAB11235.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT features of the regions of 1,081,958 bp covered by seventeen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:379-391(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, NOMENCLATURE, AND DISRUPTION PHENOTYPE.
RX PubMed=19457984; DOI=10.1093/pcp/pcp070;
RA Xiong Y., DeFraia C., Williams D., Zhang X., Mou Z.;
RT "Characterization of Arabidopsis 6-phosphogluconolactonase T-DNA insertion
RT mutants reveals an essential role for the oxidative section of the
RT plastidic pentose phosphate pathway in plant growth and development.";
RL Plant Cell Physiol. 50:1277-1291(2009).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=24008768; DOI=10.1093/mp/sst126;
RA Hoelscher C., Meyer T., von Schaewen A.;
RT "Dual-targeting of Arabidopsis 6-phosphogluconolactonase 3 (PGL3) to
RT chloroplasts and peroxisomes involves interaction with Trx m2 in the
RT cytosol.";
RL Mol. Plant 7:252-255(2014).
CC -!- FUNCTION: Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-
CC phosphogluconate. {ECO:0000250|UniProtKB:Q84WW2}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC Evidence={ECO:0000250|UniProtKB:Q84WW2};
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC 2/3. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24008768}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions. {ECO:0000269|PubMed:19457984}.
CC -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
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DR EMBL; AB016884; BAB11235.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93309.1; -; Genomic_DNA.
DR EMBL; AF378879; AAK55682.1; -; mRNA.
DR EMBL; AY052737; AAK96451.1; -; mRNA.
DR EMBL; AY085203; AAM61753.1; -; mRNA.
DR RefSeq; NP_197830.1; NM_122350.4.
DR AlphaFoldDB; Q8LEV7; -.
DR SMR; Q8LEV7; -.
DR STRING; 3702.AT5G24420.1; -.
DR MetOSite; Q8LEV7; -.
DR PaxDb; Q8LEV7; -.
DR PRIDE; Q8LEV7; -.
DR ProteomicsDB; 244623; -.
DR EnsemblPlants; AT5G24420.1; AT5G24420.1; AT5G24420.
DR GeneID; 832513; -.
DR Gramene; AT5G24420.1; AT5G24420.1; AT5G24420.
DR KEGG; ath:AT5G24420; -.
DR Araport; AT5G24420; -.
DR TAIR; locus:2152916; AT5G24420.
DR eggNOG; KOG3147; Eukaryota.
DR HOGENOM; CLU_053947_0_0_1; -.
DR InParanoid; Q8LEV7; -.
DR OMA; ERVCAWE; -.
DR OrthoDB; 1420529at2759; -.
DR PhylomeDB; Q8LEV7; -.
DR BioCyc; ARA:AT5G24420-MON; -.
DR BRENDA; 3.1.1.31; 399.
DR UniPathway; UPA00115; UER00409.
DR PRO; PR:Q8LEV7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8LEV7; baseline and differential.
DR Genevisible; Q8LEV7; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; IBA:GO_Central.
DR CDD; cd01400; 6PGL; 1.
DR InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR039104; PGLS.
DR PANTHER; PTHR11054; PTHR11054; 1.
DR Pfam; PF01182; Glucosamine_iso; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR TIGRFAMs; TIGR01198; pgl; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Hydrolase; Reference proteome.
FT CHAIN 1..252
FT /note="Probable 6-phosphogluconolactonase 5"
FT /id="PRO_0000288670"
FT CONFLICT 65
FT /note="P -> S (in Ref. 4; AAM61753)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 252 AA; 28476 MW; FAFEECE1F712FDA1 CRC64;
MAQRKMIVFP TKNELSEAMA EYTANLSAKF IKEKGLFTVV LSGGDLIDWL CKLVQPPYID
SIEWPKWHVF WVDERVCAWE DPDSNYKLAM EGFLSKVPIP DKNIYAIDKH LAADGNAEHC
ATLYEECLKN LVKEKIIPIS KKTGYPEFDL QLLGMGPDGH MASLFPNHPQ INEKQKWVTY
ITDSPKPPPK RITFTLPVIN STLYNLMAIC DKAPAKSVAE IMKHNNLSLP SAHLSAQVEN
VWYLDQAAAS EL
