ARLY_OCEIH
ID ARLY_OCEIH Reviewed; 459 AA.
AC Q8ELT9;
DT 23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=OB3128;
OS Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS 3954 / HTE831).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX NCBI_TaxID=221109;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX PubMed=12235376; DOI=10.1093/nar/gkf526;
RA Takami H., Takaki Y., Uchiyama I.;
RT "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT and its unexpected adaptive capabilities to extreme environments.";
RL Nucleic Acids Res. 30:3927-3935(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC Rule:MF_00006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR EMBL; BA000028; BAC15084.1; -; Genomic_DNA.
DR RefSeq; WP_011067525.1; NC_004193.1.
DR AlphaFoldDB; Q8ELT9; -.
DR SMR; Q8ELT9; -.
DR STRING; 221109.22778816; -.
DR EnsemblBacteria; BAC15084; BAC15084; BAC15084.
DR KEGG; oih:OB3128; -.
DR eggNOG; COG0165; Bacteria.
DR HOGENOM; CLU_027272_2_3_9; -.
DR OMA; KKNPDVF; -.
DR OrthoDB; 751464at2; -.
DR PhylomeDB; Q8ELT9; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000000822; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.275.10; -; 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; PTHR43814; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; SSF48557; 1.
DR TIGRFAMs; TIGR00838; argH; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW Reference proteome.
FT CHAIN 1..459
FT /note="Argininosuccinate lyase"
FT /id="PRO_0000137799"
SQ SEQUENCE 459 AA; 51231 MW; C10087875B890964 CRC64;
MKLWGGRFTK PTNELVDEYA SSIQFDKKLA AYDIEGSLAH VAMLKKCEII PAEDADKIAE
GLKIVLSKIE AGEAELSNEH EDIHMNVEKL LIDEVGPVGG RLHTGRSRND QVALDMRLYL
RDVIAELSDL LKAVQQSLIT QAKANMDTVM PGYTHLQRAQ PVLFAHHMMA YVFMFQRDVE
RFQDSLKRVN KSPLGAGALA GTTFPIDRHF VAEQLGFDGI CENSLDAVSD RDFVVEFLSN
SALVSTHLSR LCEELVQWSS AEFNFVELDD SFTTGSSMMP QKKNPDVAEL VRGKTGRVYG
HLMGMLTTLK GLPLAYNKDM QEDKEGMFDA HETLKGALQL FAPMMESMKV NKESMYKAVS
NDYSNATDLA DYLVNKGMTF RESHAVVGEA VLHCIEQNKY LLDLTLKEFK QYSEVIDEDI
FDVLKPEAVV NARSVEGGTA KESVLQQIAK AEKLLESAK
