MINC_PSEAE
ID MINC_PSEAE Reviewed; 263 AA.
AC Q9HYZ7;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Probable septum site-determining protein MinC {ECO:0000255|HAMAP-Rule:MF_00267};
GN Name=minC {ECO:0000255|HAMAP-Rule:MF_00267}; OrderedLocusNames=PA3243;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Cell division inhibitor that blocks the formation of polar Z
CC ring septums. Rapidly oscillates between the poles of the cell to
CC destabilize FtsZ filaments that have formed before they mature into
CC polar Z rings. Prevents FtsZ polymerization. {ECO:0000255|HAMAP-
CC Rule:MF_00267}.
CC -!- SUBUNIT: Interacts with MinD and FtsZ. {ECO:0000255|HAMAP-
CC Rule:MF_00267}.
CC -!- SIMILARITY: Belongs to the MinC family. {ECO:0000255|HAMAP-
CC Rule:MF_00267}.
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DR EMBL; AE004091; AAG06631.1; -; Genomic_DNA.
DR PIR; E83239; E83239.
DR RefSeq; NP_251933.1; NC_002516.2.
DR RefSeq; WP_003114802.1; NZ_QZGE01000019.1.
DR PDB; 6RIQ; EM; 3.10 A; A/B/E/F/H/I/L/O/P/S/T=120-263.
DR PDBsum; 6RIQ; -.
DR AlphaFoldDB; Q9HYZ7; -.
DR SMR; Q9HYZ7; -.
DR STRING; 287.DR97_4692; -.
DR PaxDb; Q9HYZ7; -.
DR PRIDE; Q9HYZ7; -.
DR DNASU; 882406; -.
DR EnsemblBacteria; AAG06631; AAG06631; PA3243.
DR GeneID; 882406; -.
DR KEGG; pae:PA3243; -.
DR PATRIC; fig|208964.12.peg.3390; -.
DR PseudoCAP; PA3243; -.
DR HOGENOM; CLU_067812_0_1_6; -.
DR InParanoid; Q9HYZ7; -.
DR OMA; RRDPLWG; -.
DR PhylomeDB; Q9HYZ7; -.
DR BioCyc; PAER208964:G1FZ6-3302-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0000902; P:cell morphogenesis; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0051302; P:regulation of cell division; IEA:InterPro.
DR GO; GO:1901891; P:regulation of cell septum assembly; IEA:InterPro.
DR Gene3D; 2.160.20.70; -; 1.
DR HAMAP; MF_00267; MinC; 1.
DR InterPro; IPR016098; CAP/MinC_C.
DR InterPro; IPR013033; MinC.
DR InterPro; IPR036145; MinC_C_sf.
DR InterPro; IPR007874; MinC_N.
DR InterPro; IPR005526; Septum_form_inhib_MinC_C.
DR PANTHER; PTHR34108; PTHR34108; 1.
DR Pfam; PF03775; MinC_C; 1.
DR Pfam; PF05209; MinC_N; 1.
DR SUPFAM; SSF63848; SSF63848; 1.
DR TIGRFAMs; TIGR01222; minC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Cell division; Reference proteome; Septation.
FT CHAIN 1..263
FT /note="Probable septum site-determining protein MinC"
FT /id="PRO_0000189054"
FT REGION 107..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 158..160
FT /evidence="ECO:0007829|PDB:6RIQ"
FT STRAND 169..175
FT /evidence="ECO:0007829|PDB:6RIQ"
FT STRAND 177..179
FT /evidence="ECO:0007829|PDB:6RIQ"
FT STRAND 188..193
FT /evidence="ECO:0007829|PDB:6RIQ"
FT STRAND 195..201
FT /evidence="ECO:0007829|PDB:6RIQ"
FT STRAND 203..208
FT /evidence="ECO:0007829|PDB:6RIQ"
FT TURN 209..211
FT /evidence="ECO:0007829|PDB:6RIQ"
FT STRAND 216..222
FT /evidence="ECO:0007829|PDB:6RIQ"
FT STRAND 225..229
FT /evidence="ECO:0007829|PDB:6RIQ"
FT STRAND 232..235
FT /evidence="ECO:0007829|PDB:6RIQ"
FT HELIX 236..241
FT /evidence="ECO:0007829|PDB:6RIQ"
FT STRAND 249..254
FT /evidence="ECO:0007829|PDB:6RIQ"
FT STRAND 257..261
FT /evidence="ECO:0007829|PDB:6RIQ"
SQ SEQUENCE 263 AA; 28124 MW; 8E1968136C76E14B CRC64;
MSQADLLDQD PVFQLKGSML AVTILELAHN DLARLERQLA DKVAQAPNFF RDTPLVMALD
KLPEGEGRLD LPALLEVCRR HGLRTLAIRA GREEDIAAAQ ALDLPVLPPS GARERPLDIK
DSAPRKPAEE PSPSAGEARP EPAKAEEKPA EPVSRPTKVV KTPVRGGMQI YAAGGDLIVL
AAVSPGAELL ADGNIHVYGP MRGRALAGVK GDATARIFCQ QLAAELVSIA GNYKVAEDLR
RSPQWGKAVH VSLSGDVLNI TRL
