ID   6PGL_AGGAC              Reviewed;         232 AA.
AC   P70715;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=6-phosphogluconolactonase;
DE            Short=6PGL;
DE            EC=3.1.1.31;
GN   Name=pgl; Synonyms=devB;
OS   Aggregatibacter actinomycetemcomitans (Actinobacillus
OS   actinomycetemcomitans) (Haemophilus actinomycetemcomitans).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Aggregatibacter.
OX   NCBI_TaxID=714;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 43718 / FDC Y4 / Serotype b;
RX   PubMed=9020051; DOI=10.1006/bbrc.1996.5917;
RA   Yoshida Y., Nakano Y., Yamashita Y., Koga T.;
RT   "The gnd gene encoding a novel 6-phosphogluconate dehydrogenase and its
RT   adjacent region of Actinobacillus actinomycetemcomitans chromosomal DNA.";
RL   Biochem. Biophys. Res. Commun. 230:220-225(1997).
CC   -!- FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC         + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       2/3.
CC   -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC       isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA13555.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; D88189; BAA13555.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P70715; -.
DR   SMR; P70715; -.
DR   STRING; 714.ACT75_04155; -.
DR   eggNOG; COG0363; Bacteria.
DR   UniPathway; UPA00115; UER00409.
DR   GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR   CDD; cd01400; 6PGL; 1.
DR   InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR   InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR039104; PGLS.
DR   PANTHER; PTHR11054; PTHR11054; 1.
DR   Pfam; PF01182; Glucosamine_iso; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR01198; pgl; 1.
PE   3: Inferred from homology;
KW   Hydrolase.
FT   CHAIN           1..232
FT                   /note="6-phosphogluconolactonase"
FT                   /id="PRO_0000090088"
SQ   SEQUENCE   232 AA;  26224 MW;  578F29F1751CC40A CRC64;
     MNYITFPTAQ HAVEKIAQEF VIYSQLNHPA HISLSGGSTP KLLFKTLAQS PYAEQINWRN
     LHFWWGDDRM VSPSDPESNY GEVQKLLFDH IQIPAENIHR IRGENEPHFE LKRFQAELSA
     VISDGVFDWI ILGMGADGHT SSLFPHQTNF DDENLAVIAK HPESGQIRIS KTAKLIEQAK
     RITYLVTGEG KAEILKEIQS TPAENLPYPA AKIYAKNGVT EWYLDKDAAK LL