MINC_THEMA
ID MINC_THEMA Reviewed; 210 AA.
AC Q9X0D7;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 135.
DE RecName: Full=Probable septum site-determining protein MinC;
GN Name=minC; OrderedLocusNames=TM_1047;
OS Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826
OS / MSB8).
OC Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX NCBI_TaxID=243274;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8;
RX PubMed=10360571; DOI=10.1038/20601;
RA Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J., Haft D.H.,
RA Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A., McDonald L.A.,
RA Utterback T.R., Malek J.A., Linher K.D., Garrett M.M., Stewart A.M.,
RA Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L., Heidelberg J.F.,
RA Sutton G.G., Fleischmann R.D., Eisen J.A., White O., Salzberg S.L.,
RA Smith H.O., Venter J.C., Fraser C.M.;
RT "Evidence for lateral gene transfer between Archaea and Bacteria from
RT genome sequence of Thermotoga maritima.";
RL Nature 399:323-329(1999).
CC -!- FUNCTION: Cell division inhibitor that blocks the formation of polar Z
CC ring septums. Rapidly oscillates between the poles of the cell to
CC destabilize FtsZ filaments that have formed before they mature into
CC polar Z rings. Prevents FtsZ polymerization (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with MinD and FtsZ. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MinC family. {ECO:0000305}.
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DR EMBL; AE000512; AAD36124.1; -; Genomic_DNA.
DR PIR; A72301; A72301.
DR RefSeq; NP_228853.1; NC_000853.1.
DR RefSeq; WP_008193407.1; NZ_CP011107.1.
DR PDB; 1HF2; X-ray; 2.20 A; A/B/C/D=1-210.
DR PDBsum; 1HF2; -.
DR AlphaFoldDB; Q9X0D7; -.
DR SMR; Q9X0D7; -.
DR STRING; 243274.THEMA_09125; -.
DR EnsemblBacteria; AAD36124; AAD36124; TM_1047.
DR KEGG; tma:TM1047; -.
DR eggNOG; COG0850; Bacteria.
DR InParanoid; Q9X0D7; -.
DR OMA; EMECAYI; -.
DR OrthoDB; 1665744at2; -.
DR EvolutionaryTrace; Q9X0D7; -.
DR Proteomes; UP000008183; Chromosome.
DR GO; GO:0000902; P:cell morphogenesis; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:1901891; P:regulation of cell septum assembly; IEA:InterPro.
DR Gene3D; 2.160.20.70; -; 1.
DR HAMAP; MF_00267; MinC; 1.
DR InterPro; IPR016098; CAP/MinC_C.
DR InterPro; IPR013033; MinC.
DR InterPro; IPR036145; MinC_C_sf.
DR InterPro; IPR005526; Septum_form_inhib_MinC_C.
DR PANTHER; PTHR34108; PTHR34108; 1.
DR Pfam; PF03775; MinC_C; 1.
DR SUPFAM; SSF63848; SSF63848; 1.
DR TIGRFAMs; TIGR01222; minC; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Cell division; Reference proteome; Septation.
FT CHAIN 1..210
FT /note="Probable septum site-determining protein MinC"
FT /id="PRO_0000189066"
FT STRAND 2..7
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 10..15
FT /evidence="ECO:0007829|PDB:1HF2"
FT HELIX 21..34
FT /evidence="ECO:0007829|PDB:1HF2"
FT HELIX 36..38
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 44..49
FT /evidence="ECO:0007829|PDB:1HF2"
FT HELIX 52..55
FT /evidence="ECO:0007829|PDB:1HF2"
FT HELIX 56..58
FT /evidence="ECO:0007829|PDB:1HF2"
FT HELIX 59..68
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 72..77
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 80..82
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 85..89
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 94..97
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 102..104
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 112..118
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 120..124
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 131..136
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 138..144
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 146..150
FT /evidence="ECO:0007829|PDB:1HF2"
FT TURN 152..154
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 159..165
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 168..172
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 175..177
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 187..192
FT /evidence="ECO:0007829|PDB:1HF2"
FT STRAND 195..200
FT /evidence="ECO:0007829|PDB:1HF2"
FT HELIX 201..203
FT /evidence="ECO:0007829|PDB:1HF2"
SQ SEQUENCE 210 AA; 22727 MW; E900E42AE905D023 CRC64;
MVDFKMTKEG LVLLIKDYQN LEEVLNAISA RITQMGGFFA KGDRISLMIE NHNKHSQDIP
RIVSHLRNLG LEVSQILVGS TVEGKENDLK VQSRTTVEST GKVIKRNIRS GQTVVHSGDV
IVFGNVNKGA EILAGGSVVV FGKAQGNIRA GLNEGGQAVV AALDLQTSLI QIAGFITHSK
GEENVPSIAH VKGNRIVIEP FDKVSFERSE
