ID   MIND_HELPY              Reviewed;         268 AA.
AC   O25098;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Septum site-determining protein MinD;
DE   AltName: Full=Cell division inhibitor MinD;
GN   Name=minD; OrderedLocusNames=HP_0331;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: ATPase required for the correct placement of the division
CC       site. Cell division inhibitors MinC and MinD act in concert to form an
CC       inhibitor capable of blocking formation of the polar Z ring septums.
CC       Rapidly oscillates between the poles of the cell to destabilize FtsZ
CC       filaments that have formed before they mature into polar Z rings (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with MinC and FtsZ. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ParA family. MinD subfamily. {ECO:0000305}.
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DR   EMBL; AE000511; AAD07400.1; -; Genomic_DNA.
DR   PIR; C64561; C64561.
DR   RefSeq; NP_207129.1; NC_000915.1.
DR   RefSeq; WP_001019069.1; NC_018939.1.
DR   AlphaFoldDB; O25098; -.
DR   SMR; O25098; -.
DR   DIP; DIP-3247N; -.
DR   IntAct; O25098; 4.
DR   MINT; O25098; -.
DR   STRING; 85962.C694_01675; -.
DR   PaxDb; O25098; -.
DR   EnsemblBacteria; AAD07400; AAD07400; HP_0331.
DR   KEGG; hpy:HP_0331; -.
DR   PATRIC; fig|85962.47.peg.353; -.
DR   eggNOG; COG2894; Bacteria.
DR   OMA; CESAKAY; -.
DR   PhylomeDB; O25098; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0051782; P:negative regulation of cell division; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR002586; CobQ/CobB/MinD/ParA_Nub-bd_dom.
DR   InterPro; IPR010223; MinD.
DR   InterPro; IPR025501; MinD_FleN.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01656; CbiA; 1.
DR   PIRSF; PIRSF003092; MinD; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01968; minD_bact; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Cell membrane; Membrane;
KW   Nucleotide-binding; Reference proteome; Septation.
FT   CHAIN           1..268
FT                   /note="Septum site-determining protein MinD"
FT                   /id="PRO_0000201971"
FT   BINDING         11..18
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:Q72H90"
SQ   SEQUENCE   268 AA;  29294 MW;  9E14766E8D309476 CRC64;
     MAIVVTITSG KGGVGKSTTT ANLAIGLAES GKKVVAVDFD IGLRNLDMIL GLENRIVYDV
     VDVMEKNCNL SQALITDKKT KNLSFLAASQ SKDKNILDKE KVAILINALR ADFDYILIDS
     PAGIESGFEH AILHADMALV VVTPEVSSLR DSDRVVGIID AKSNRAKKGM EVHKHLIINR
     LKPELVANGE MISIEEVLKI LCLPLIGIIP EDHHIISATN KGEPVIRTDC ESAKAYQRIT
     RRILGEEVEY VEFKAKRGFF SALKGIFS