ID   MINE_CLOD6              Reviewed;          94 AA.
AC   Q18B11;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Cell division topological specificity factor {ECO:0000255|HAMAP-Rule:MF_00262};
GN   Name=minE {ECO:0000255|HAMAP-Rule:MF_00262}; OrderedLocusNames=CD630_11510;
OS   Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC   Clostridioides.
OX   NCBI_TaxID=272563;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=630;
RX   PubMed=16804543; DOI=10.1038/ng1830;
RA   Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA   Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA   Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA   Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA   Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA   Price C., Rabbinowitsch E., Sharp S., Simmonds M., Stevens K., Unwin L.,
RA   Whithead S., Dupuy B., Dougan G., Barrell B., Parkhill J.;
RT   "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT   mobile, mosaic genome.";
RL   Nat. Genet. 38:779-786(2006).
CC   -!- FUNCTION: Prevents the cell division inhibition by proteins MinC and
CC       MinD at internal division sites while permitting inhibition at polar
CC       sites. This ensures cell division at the proper site by restricting the
CC       formation of a division septum at the midpoint of the long axis of the
CC       cell. {ECO:0000255|HAMAP-Rule:MF_00262}.
CC   -!- SIMILARITY: Belongs to the MinE family. {ECO:0000255|HAMAP-
CC       Rule:MF_00262}.
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DR   EMBL; AM180355; CAJ68004.1; -; Genomic_DNA.
DR   RefSeq; WP_003419058.1; NZ_CP010905.2.
DR   RefSeq; YP_001087643.1; NC_009089.1.
DR   AlphaFoldDB; Q18B11; -.
DR   SMR; Q18B11; -.
DR   STRING; 272563.CD630_11510; -.
DR   EnsemblBacteria; CAJ68004; CAJ68004; CD630_11510.
DR   GeneID; 66353561; -.
DR   KEGG; cdf:CD630_11510; -.
DR   KEGG; pdc:CDIF630_01298; -.
DR   PATRIC; fig|272563.120.peg.1200; -.
DR   eggNOG; COG0851; Bacteria.
DR   OMA; VHDRANV; -.
DR   PhylomeDB; Q18B11; -.
DR   BioCyc; PDIF272563:G12WB-1281-MON; -.
DR   Proteomes; UP000001978; Chromosome.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0032955; P:regulation of division septum assembly; IEA:InterPro.
DR   Gene3D; 3.30.1070.10; -; 1.
DR   HAMAP; MF_00262; MinE; 1.
DR   InterPro; IPR005527; MinE.
DR   InterPro; IPR036707; MinE_sf.
DR   Pfam; PF03776; MinE; 1.
DR   SUPFAM; SSF55229; SSF55229; 1.
DR   TIGRFAMs; TIGR01215; minE; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Reference proteome.
FT   CHAIN           1..94
FT                   /note="Cell division topological specificity factor"
FT                   /id="PRO_0000298099"
SQ   SEQUENCE   94 AA;  10686 MW;  048E5D04DEAEDBB3 CRC64;
     MLDLFRVFSN EAKTSKSVAK ERLKLVLVHD RVDCSPQLLE MIKTDILKVI ANYAEIEDDG
     LEIKMSKCRG EHDDKPVSAL VANIPLKNIK DRCM