ID   MINE_HELPY              Reviewed;          77 AA.
AC   O25099;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Cell division topological specificity factor;
GN   Name=minE; OrderedLocusNames=HP_0332;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- FUNCTION: Prevents the cell division inhibition by proteins MinC and
CC       MinD at internal division sites while permitting inhibition at polar
CC       sites. This ensures cell division at the proper site by restricting the
CC       formation of a division septum at the midpoint of the long axis of the
CC       cell (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MinE family. {ECO:0000305}.
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DR   EMBL; AE000511; AAD07401.1; -; Genomic_DNA.
DR   PIR; D64561; D64561.
DR   RefSeq; NP_207130.1; NC_000915.1.
DR   RefSeq; WP_000051415.1; NC_018939.1.
DR   PDB; 3KU7; X-ray; 2.80 A; A/B=1-77.
DR   PDB; 3MCD; X-ray; 3.20 A; A/B=1-77.
DR   PDBsum; 3KU7; -.
DR   PDBsum; 3MCD; -.
DR   AlphaFoldDB; O25099; -.
DR   SMR; O25099; -.
DR   DIP; DIP-3672N; -.
DR   IntAct; O25099; 2.
DR   MINT; O25099; -.
DR   STRING; 85962.C694_01680; -.
DR   PaxDb; O25099; -.
DR   EnsemblBacteria; AAD07401; AAD07401; HP_0332.
DR   KEGG; hpy:HP_0332; -.
DR   PATRIC; fig|85962.47.peg.354; -.
DR   eggNOG; COG0851; Bacteria.
DR   OMA; TIMLSHE; -.
DR   PhylomeDB; O25099; -.
DR   EvolutionaryTrace; O25099; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0032955; P:regulation of division septum assembly; IEA:InterPro.
DR   Gene3D; 3.30.1070.10; -; 1.
DR   HAMAP; MF_00262; MinE; 1.
DR   InterPro; IPR005527; MinE.
DR   InterPro; IPR036707; MinE_sf.
DR   Pfam; PF03776; MinE; 1.
DR   SUPFAM; SSF55229; SSF55229; 1.
DR   TIGRFAMs; TIGR01215; minE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell cycle; Cell division; Reference proteome.
FT   CHAIN           1..77
FT                   /note="Cell division topological specificity factor"
FT                   /id="PRO_0000205877"
FT   STRAND          15..17
FT                   /evidence="ECO:0007829|PDB:3KU7"
FT   STRAND          19..29
FT                   /evidence="ECO:0007829|PDB:3KU7"
FT   HELIX           35..50
FT                   /evidence="ECO:0007829|PDB:3KU7"
FT   STRAND          54..58
FT                   /evidence="ECO:0007829|PDB:3KU7"
FT   STRAND          66..74
FT                   /evidence="ECO:0007829|PDB:3KU7"
SQ   SEQUENCE   77 AA;  8920 MW;  2440A6E9A42651A7 CRC64;
     MSLFDFFKNK GSAATATDRL KLILAKERTL NLPYMEEMRK EIIAVIQKYT KSSDIHFKTL
     DSNQSVETIE VEIILPR