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ARLY_PSEAE
ID   ARLY_PSEAE              Reviewed;         464 AA.
AC   P50987; Q9HTT6;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 2.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=PA5263;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-243.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RA   Whitchurch C.B., Alm R.A., Mattick J.S.;
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 42-241.
RX   PubMed=2121708; DOI=10.1128/jb.172.11.6252-6260.1990;
RA   Mohr C.D., Deretic V.;
RT   "Gene-scrambling mutagenesis: generation and analysis of insertional
RT   mutations in the alginate regulatory region of Pseudomonas aeruginosa.";
RL   J. Bacteriol. 172:6252-6260(1990).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; AE004091; AAG08648.1; -; Genomic_DNA.
DR   EMBL; L48729; AAA88425.1; -; Genomic_DNA.
DR   EMBL; M61001; AAA25721.1; -; Genomic_DNA.
DR   PIR; A37143; A37143.
DR   PIR; E82989; E82989.
DR   RefSeq; NP_253950.1; NC_002516.2.
DR   RefSeq; WP_003114030.1; NZ_QZGE01000002.1.
DR   AlphaFoldDB; P50987; -.
DR   SMR; P50987; -.
DR   STRING; 287.DR97_2634; -.
DR   PaxDb; P50987; -.
DR   PRIDE; P50987; -.
DR   EnsemblBacteria; AAG08648; AAG08648; PA5263.
DR   GeneID; 879636; -.
DR   KEGG; pae:PA5263; -.
DR   PATRIC; fig|208964.12.peg.5516; -.
DR   PseudoCAP; PA5263; -.
DR   HOGENOM; CLU_027272_2_3_6; -.
DR   InParanoid; P50987; -.
DR   OMA; KKNPDVF; -.
DR   PhylomeDB; P50987; -.
DR   BioCyc; PAER208964:G1FZ6-5384-MON; -.
DR   UniPathway; UPA00068; UER00114.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IBA:GO_Central.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IBA:GO_Central.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW   Reference proteome.
FT   CHAIN           1..464
FT                   /note="Argininosuccinate lyase"
FT                   /id="PRO_0000137806"
FT   CONFLICT        6..7
FT                   /note="TN -> PY (in Ref. 2; AAA88425)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        11..37
FT                   /note="GGRFSEPVDAFVARFTASVDFDKRLYR -> VDPLQASPSTPSSRRVRRQPS
FT                   TSTSVLYH (in Ref. 2; AAA88425)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        184
FT                   /note="D -> E (in Ref. 2; AAA88425)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        189..220
FT                   /note="VDCRKRVNRMPLGSAALAGTTYPIQREITCQL -> RRLPQAGQPHAARLGG
FT                   PGRHHLPDPARRSPASC (in Ref. 2; AAA88425 and 3; AAA25721)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   464 AA;  51641 MW;  BE16C2C3CFE423E9 CRC64;
     MSVEKTNQSW GGRFSEPVDA FVARFTASVD FDKRLYRHDI MGSIAHATML AKVGVLSDAE
     RDAIVDGLQQ IQAEIEAGSF DWRVDLEDVH MNIEARLTDR IGVTGKKLHT GRSRNDQVAT
     DIRLWLRDEI DTILAEITRL QEGLLGLAEA EADTIMPGFT HLQTAQPVTF GHHLLAWFEM
     LGRDYERLVD CRKRVNRMPL GSAALAGTTY PIQREITCQL LGFDAVGGNS LDGVSDRDFA
     IEFCAAASLA MMHLSRFSEE LVLWTSAQFQ FIDLPDRFCT GSSIMPQKKN PDVPELVRGK
     SGRVFGALTG LLTLMKGQPL AYNKDNQEDK EPLFDAADTL RDSLRAFADM VPAIRPRREI
     MREAARRGFS TATDLADYLV RKGLPFRDCH EIVGHAVKYG VDSGKDLAEM SLDELRRFSE
     QIDADVFDVL TLEGSVNARD HIGGTAPNQV RAAVARGRKL LAQR
 
 
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