MINJ_BACSU
ID MINJ_BACSU Reviewed; 397 AA.
AC O34375; Q795D8;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Cell division topological determinant MinJ;
GN Name=minJ; Synonyms=swrAB, yvjD; OrderedLocusNames=BSU35220;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Lazarevic V., Soldo B., Rivolta C., Reynolds S., Mauel C., Karamata D.;
RT "Nucleotide sequence of the 300-304 chromosomal segment of Bacillus
RT subtilis.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP PRELIMINARY FUNCTION.
RX PubMed=16030230; DOI=10.1128/jb.187.15.5356-5366.2005;
RA Calvio C., Celandroni F., Ghelardi E., Amati G., Salvetti S., Ceciliani F.,
RA Galizzi A., Senesi S.;
RT "Swarming differentiation and swimming motility in Bacillus subtilis are
RT controlled by swrA, a newly identified dicistronic operon.";
RL J. Bacteriol. 187:5356-5366(2005).
RN [4]
RP FUNCTION, INTERACTION WITH DIVIVA AND MIND, SUBCELLULAR LOCATION, AND
RP DISRUPTION PHENOTYPE.
RC STRAIN=3610;
RX PubMed=18976281; DOI=10.1111/j.1365-2958.2008.06469.x;
RA Patrick J.E., Kearns D.B.;
RT "MinJ (YvjD) is a topological determinant of cell division in Bacillus
RT subtilis.";
RL Mol. Microbiol. 70:1166-1179(2008).
RN [5]
RP FUNCTION, INTERACTION WITH DIVIVA AND MIND, SUBCELLULAR LOCATION, AND
RP DISRUPTION PHENOTYPE.
RC STRAIN=168;
RX PubMed=19019154; DOI=10.1111/j.1365-2958.2008.06501.x;
RA Bramkamp M., Emmins R., Weston L., Donovan C., Daniel R.A., Errington J.;
RT "A novel component of the division-site selection system of Bacillus
RT subtilis and a new mode of action for the division inhibitor MinCD.";
RL Mol. Microbiol. 70:1556-1569(2008).
RN [6]
RP FUNCTION OF THE MIN SYSTEM, AND SUBCELLULAR LOCATION.
RX PubMed=20352045; DOI=10.1371/journal.pone.0009850;
RA van Baarle S., Bramkamp M.;
RT "The MinCDJ system in Bacillus subtilis prevents minicell formation by
RT promoting divisome disassembly.";
RL PLoS ONE 5:E9850-E9850(2010).
CC -!- FUNCTION: The main function of the Min system is to promote the
CC disassembly of the cytokinetic ring after cell division, thereby
CC ensuring that division occurs only once per cell cycle. MinJ acts as a
CC bridge between DivIVA and MinD. May modulate activity and localization
CC of MinD and MinC through direct interaction with MinD.
CC {ECO:0000269|PubMed:18976281, ECO:0000269|PubMed:19019154,
CC ECO:0000269|PubMed:20352045}.
CC -!- SUBUNIT: Interacts directly with DivIVA and MinD.
CC {ECO:0000269|PubMed:18976281, ECO:0000269|PubMed:19019154}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18976281,
CC ECO:0000269|PubMed:19019154, ECO:0000269|PubMed:20352045}; Multi-pass
CC membrane protein {ECO:0000269|PubMed:18976281,
CC ECO:0000269|PubMed:19019154, ECO:0000269|PubMed:20352045}.
CC Note=Localization depends on DivIVA and on the state of the cell cycle.
CC Present at both cell poles in non-dividing cells. As cells prepare to
CC divide, moves from poles to mid-cell. Then, after division is
CC completed, stays associated with new poles, but also moves back to old
CC poles.
CC -!- DISRUPTION PHENOTYPE: Mutants show defects in homologous recombination,
CC swarming motility and cell division. {ECO:0000269|PubMed:18976281,
CC ECO:0000269|PubMed:19019154}.
CC -!- SIMILARITY: Belongs to the MinJ family. {ECO:0000305}.
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DR EMBL; AF017113; AAC67265.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15539.1; -; Genomic_DNA.
DR PIR; F70042; F70042.
DR RefSeq; NP_391402.1; NC_000964.3.
DR RefSeq; WP_003242631.1; NZ_JNCM01000033.1.
DR AlphaFoldDB; O34375; -.
DR SMR; O34375; -.
DR STRING; 224308.BSU35220; -.
DR PaxDb; O34375; -.
DR EnsemblBacteria; CAB15539; CAB15539; BSU_35220.
DR GeneID; 936668; -.
DR KEGG; bsu:BSU35220; -.
DR PATRIC; fig|224308.179.peg.3812; -.
DR eggNOG; COG0265; Bacteria.
DR OMA; EHHELGI; -.
DR PhylomeDB; O34375; -.
DR BioCyc; BSUB:BSU35220-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF17820; PDZ_6; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cell membrane; Membrane; Reference proteome;
KW Septation; Transmembrane; Transmembrane helix.
FT CHAIN 1..397
FT /note="Cell division topological determinant MinJ"
FT /id="PRO_0000360825"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 279..363
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
SQ SEQUENCE 397 AA; 43666 MW; 2959596C5D1962C2 CRC64;
MSVQWGIELL KSAGLFFLHP LFWFFIIITL AFGYVRIKRE RKTFHTRIAD IYDDLKFTYT
KGLIPGLLLS VILGGLGISI PLGLLAIIAV ITAAAAFTLR ANWMSAAYIV SVSMLIGFGL
QIYQAEPFLE RFPQGFAVVW PAVAVFLGLL IITEGAVAYR SAHVRTSPAL VVSSRGLPIG
QQLANRVWLL PLFLLVPGNG LESHLSWWPV FTVPGGSFHF LWIPYFVGFG QRVQGSLPET
SIRITAKRVC ILGLAVAVLG AASLLWTPLA GAAVCTALLG RIFLSIKQRV NDNAAPFYFS
KRDQGLMVLG IIPNTPAEDL ELKIGEIITK VNGIPVKNVS DFYEALQHNR AYVKLEIIGL
NGEIRFDQRA SYEGEHHELG ILFVKDDRED EAVASGS
