ID   MIOA_XENLA              Reviewed;         880 AA.
AC   Q5U5D4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=GATOR complex protein MIOS-A {ECO:0000305};
GN   Name=mios-a {ECO:0000305};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As a component of the GATOR complex may function in the amino
CC       acid-sensing branch of the TORC1 signaling pathway.
CC       {ECO:0000250|UniProtKB:Q9NXC5}.
CC   -!- SUBUNIT: Probably part of the GATOR complex.
CC       {ECO:0000250|UniProtKB:Q9NXC5}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9NXC5}.
CC   -!- SIMILARITY: Belongs to the WD repeat mio family. {ECO:0000305}.
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DR   EMBL; BC084750; AAH84750.1; -; mRNA.
DR   RefSeq; NP_001088430.1; NM_001094961.1.
DR   RefSeq; XP_018124261.1; XM_018268772.1.
DR   AlphaFoldDB; Q5U5D4; -.
DR   SMR; Q5U5D4; -.
DR   DNASU; 495294; -.
DR   GeneID; 495294; -.
DR   KEGG; xla:495294; -.
DR   CTD; 495294; -.
DR   OMA; QSHNSTC; -.
DR   OrthoDB; 890767at2759; -.
DR   Proteomes; UP000186698; Chromosome 6S.
DR   Bgee; 495294; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd16691; mRING-H2-C3H3C2_Mio; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR037593; MIOS/Sea4.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR031488; Zn_ribbon_mio.
DR   PANTHER; PTHR16453; PTHR16453; 1.
DR   Pfam; PF17034; zinc_ribbon_16; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..880
FT                   /note="GATOR complex protein MIOS-A"
FT                   /id="PRO_0000329408"
FT   REPEAT          60..102
FT                   /note="WD 1"
FT   REPEAT          113..157
FT                   /note="WD 2"
FT   REPEAT          185..224
FT                   /note="WD 3"
FT   REPEAT          226..264
FT                   /note="WD 4"
FT   REPEAT          268..309
FT                   /note="WD 5"
FT   REPEAT          399..441
FT                   /note="WD 6"
SQ   SEQUENCE   880 AA;  98656 MW;  B9B0307B1502E77A CRC64;
     MSGSKPDILW APHHVDRFVV CDSELSLYHI ESAASPSSEL KAGSLRLSEE TTATLLAINS
     DTPYMKCVAW YPKYDPECLL AVGQANGRVV LTSLGQDHNS KCKDLIGKEF VPKHARQCNT
     LAWNPQDSNW LAAGLDKHRA DFSVLIWDIS SKYTPEVAVP AEKVRLAPGD SETCSVVTKP
     LYELGQNDAC LSLCWLPRDQ KLLLAGMHRN LAIFDLRNTN QKMFVNTKAV QGVTVDPHFH
     DRVASFFEGQ VAIWDLRKFE KPVLTLTEQP KPLTKVAWCP TRTGLLATLT RDSNIIRLYD
     MQHTPTPIGD ETEPTIIERS VQPCDNYIAS FAWHPTSQNR MVVVTPNRSM SDFTVFERIS
     LAWSPTTSLM WACSRQLYEC TEEGKGSSSL DRDIATKMRL RALSRYGLDT EQVWRNHLLA
     GNDDPQLKSL WYTLHFMKQY AEDIDQKSSG NKGLLVYAGI KAITKSSMGT TESFRHSWTG
     SDRQADIVHY SSEERCLALQ LCGWRTKGAD SDMGPFLNSL EQEGEWERAA AIALFNRDIR
     RAIQILNKGA STGKGNLNLN VVAMALSGYT DEKKSLWREM CSTLRLQLNN PYLCVMFAFL
     TSEPGVYDGV LYENSMAVRD RVAFSCLFLN DAQLSRYFDK LTNEMKEAGN LEGILLTGLT
     KDGVDLIESY VDRTGDVQTA SYCMLQGSPS DVLKDERVQY WIESYRNLLD AWRFWHKRAE
     FDIHRSKLDP SSKPLAQVFV SCNFCGKSIS YSCSSVPHQG RGFSQYGVSG SPTKSKFTSC
     PGCRKPLPRC ALCLINMGNP VSSSPGASKS DEKVDLSKEK KVAKFNNWFT WCHNCRHGGH
     AGHMLSWFKD HSECPVSACS CKCMQLDTTG NLVPAENVQP