ID   MIOB_XENLA              Reviewed;         880 AA.
AC   A4QNS7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=GATOR complex protein MIOS-B {ECO:0000305};
GN   Name=mios-b {ECO:0000305};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As a component of the GATOR complex may function in the amino
CC       acid-sensing branch of the TORC1 signaling pathway.
CC       {ECO:0000250|UniProtKB:Q9NXC5}.
CC   -!- SUBUNIT: Probably part of the GATOR complex.
CC       {ECO:0000250|UniProtKB:Q9NXC5}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9NXC5}.
CC   -!- SIMILARITY: Belongs to the WD repeat mio family. {ECO:0000305}.
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DR   EMBL; BC139501; AAI39502.1; -; mRNA.
DR   RefSeq; NP_001091443.1; NM_001097974.1.
DR   AlphaFoldDB; A4QNS7; -.
DR   SMR; A4QNS7; -.
DR   BioGRID; 674601; 1.
DR   IntAct; A4QNS7; 1.
DR   PRIDE; A4QNS7; -.
DR   GeneID; 100049152; -.
DR   KEGG; xla:100049152; -.
DR   CTD; 100049152; -.
DR   OrthoDB; 890767at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 100049152; Expressed in testis and 19 other tissues.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd16691; mRING-H2-C3H3C2_Mio; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR037593; MIOS/Sea4.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR031488; Zn_ribbon_mio.
DR   PANTHER; PTHR16453; PTHR16453; 1.
DR   Pfam; PF17034; zinc_ribbon_16; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..880
FT                   /note="GATOR complex protein MIOS-B"
FT                   /id="PRO_0000329409"
FT   REPEAT          60..102
FT                   /note="WD 1"
FT   REPEAT          113..157
FT                   /note="WD 2"
FT   REPEAT          185..224
FT                   /note="WD 3"
FT   REPEAT          226..264
FT                   /note="WD 4"
FT   REPEAT          268..309
FT                   /note="WD 5"
FT   REPEAT          399..441
FT                   /note="WD 6"
SQ   SEQUENCE   880 AA;  98572 MW;  BA8B511F0F186444 CRC64;
     MSGSKPDILW APHHVDRFVV GDSELSLYHI ESAASPGSEL KAGSLRLSEE TIATLLAINS
     DTPYMKCVAW YPKYDPECLL AVGQANGRVV LTSLGQDHNS KCKDLIGKEF VPKHARQCNT
     LAWNPLDSNW LAAGLDKHRA DFSVLIWDIS SKYTPEVAVP TEKVRLAPGD SETCSVVTKP
     LYELGQNDAC LSLCWLPRDQ KLLLAGMHRN LAIFDLRNTN QKIFVNTKAA QGVTVDPHFH
     DRVASFFEGQ VAIWDLRKFE KPVLTLTEQP KPLTKVAWCP TRTGLLATLT RDSNIIRLYD
     MQHTPTPIGD ETEPTIIERS VQPCDNYIAS FAWHPTSQNR MVVVTPNRSM SDFTVFERIS
     LAWSPTTSLM WACSRQLYEC TEEGKGSSSL DQDIATKMRL RALSRYGLDT EQVWRNHMLA
     GNDDPQLKSL WYTLHFMKQY AEDIDQKSSG NKGSLVYAGI KAITKSSVGT TESFRHSWTC
     SDRQADIVHY SSEERWLALQ LCGWRTKGAD ADMGPFLNSL EQEGEWERAA AIALFNRDIR
     RAIQILNKGA STGKGNLNLN VVAMALSGYT DEKNSLWREM CSTLRLQLNN PYLCVMFAFL
     TSEPGLYDGV LYENSMAVRD RVAFACLFLN DSQLSRYIDK LTNEMKEAGN LEGILLTGLT
     KDGVDLIESY VDRTGDVQTA SYCMLQGSPS DVLKDERVQY WIESYRNLLD AWRFWHKRAE
     FDIHRSKLDP SSKPLAQVFV SCNFCGKSIS YSCSSVPHQG RGFSQYGVSG SPTKSKFTSC
     PGCRKPLPRC ALCLINMGNP VSSSPGASKS DEKVDLSKEK KVAKFNNWFT WCHNCRHGGH
     AGHMLSWFKD HSECPVSACS CKCMQLDTTG NLVPAENVQP