ID   MIO_DANRE               Reviewed;         876 AA.
AC   Q802U2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=GATOR complex protein MIOS {ECO:0000305};
GN   Name=mios {ECO:0000250|UniProtKB:Q9NXC5};
GN   ORFNames=zgc:55958 {ECO:0000312|EMBL:AAH47198.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As a component of the GATOR complex may function in the amino
CC       acid-sensing branch of the TORC1 signaling pathway.
CC       {ECO:0000250|UniProtKB:Q9NXC5}.
CC   -!- SUBUNIT: Probably part of the GATOR complex.
CC       {ECO:0000250|UniProtKB:Q9NXC5}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9NXC5}.
CC   -!- SIMILARITY: Belongs to the WD repeat mio family. {ECO:0000305}.
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DR   EMBL; BC047198; AAH47198.1; -; mRNA.
DR   RefSeq; NP_958490.1; NM_201333.1.
DR   AlphaFoldDB; Q802U2; -.
DR   SMR; Q802U2; -.
DR   STRING; 7955.ENSDARP00000109722; -.
DR   PaxDb; Q802U2; -.
DR   Ensembl; ENSDART00000169697; ENSDARP00000132748; ENSDARG00000102587.
DR   GeneID; 393208; -.
DR   KEGG; dre:393208; -.
DR   CTD; 54468; -.
DR   ZFIN; ZDB-GENE-040426-856; mios.
DR   eggNOG; KOG1008; Eukaryota.
DR   GeneTree; ENSGT00390000015038; -.
DR   InParanoid; Q802U2; -.
DR   OrthoDB; 890767at2759; -.
DR   PhylomeDB; Q802U2; -.
DR   TreeFam; TF324074; -.
DR   Reactome; R-DRE-9639288; Amino acids regulate mTORC1.
DR   PRO; PR:Q802U2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 16.
DR   Bgee; ENSDARG00000102587; Expressed in blastula and 27 other tissues.
DR   ExpressionAtlas; Q802U2; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR   GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR   CDD; cd16691; mRING-H2-C3H3C2_Mio; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR037593; MIOS/Sea4.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR031488; Zn_ribbon_mio.
DR   PANTHER; PTHR16453; PTHR16453; 1.
DR   Pfam; PF17034; zinc_ribbon_16; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..876
FT                   /note="GATOR complex protein MIOS"
FT                   /id="PRO_0000329407"
FT   REPEAT          59..101
FT                   /note="WD 1"
FT   REPEAT          112..156
FT                   /note="WD 2"
FT   REPEAT          182..222
FT                   /note="WD 3"
FT   REPEAT          224..262
FT                   /note="WD 4"
FT   REPEAT          266..307
FT                   /note="WD 5"
FT   REPEAT          400..440
FT                   /note="WD 6"
SQ   SEQUENCE   876 AA;  98182 MW;  C22694B1DA0D4D48 CRC64;
     MSSGYKPDIL WSPHHADRYV ICDTELSLYR IGPSGSSETK AGALQLSEET AATLLAINSD
     TPFMKCVAWY PKHEPECLLA VGHTNGRVVL TSLGQSHNSK SKDLAGKEFV PKHARQCNTL
     AWNPVDSNWL AAGLDKHRAD FSVLIWDISS KFSPEAVPAE KVRLSGDADS GLLVTKPLYE
     LGQNDACLSL CWLPRDHQKL LLAGMHRNLA IFDLRNTSQK TFVNTKAIQG VTVDPHFQDR
     VASYFEGQVA IWDLRKFEKP VFTLNEQPKP LTKVAWCPTR MGLLATLTRD SNIIRLYDMQ
     HTPMPFGDEV EPTIMERGVQ PCSESIISSF AWHPSAQNRM VVVSPSRVMN DFTLFERISL
     AWSSTTSLMW ACGRHLYECA EDSGQAAEAE KDIATKMRER AQSRYGHDTV QVWRNHVLAG
     GDDPQLRSLW YTLHFMKQYT ENVEQKQQSN KQSLIYSGIK NIVKSSSGTT ETRRCWSGSD
     RQTDVPRFHS EERSLALQLC GWISQGPDTD VEPFLKSLEQ EGEWERAAAV ALFNLDIRRA
     IQILNKGASS EKGDLNLNVV AMALSGYTDE KNSLWREMCS SLRLQLKKPY LCIMFAFLTS
     EPGAYDGVLY ESRVAVRDRV AFACMFLNDA QLPRYIDKLT NEMKEAGNLE GILLTGLTKD
     GVDLMESYVD RTGDVQTASF CMLKGSPGEV LKDPRVQCWI ENYRNLLDAW RFWHKRAEFD
     IHRSKLDPSS KPLAQVFVSC NFCGKSISYS CSAMPHQGRG FSQYGVSGSP TKSKVTSCPG
     CRKPLPRCAL CLMNMGTPVS SCPGTGKADE KADLTRDKKL AQFNNWFTWC HNCRHGGHAG
     HMLSWFRDHS ECPVSACTCK CMQLDTTGNL VPSDSV