MIP_LEGPN
ID MIP_LEGPN Reviewed; 233 AA.
AC Q70YI1; P20380; P69059; Q549M0;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Outer membrane protein MIP;
DE EC=5.2.1.8;
DE AltName: Full=Macrophage infectivity potentiator;
DE AltName: Full=Peptidyl-prolyl cis-trans isomerase;
DE Short=PPIase;
DE AltName: Full=Rotamase;
DE Flags: Precursor;
GN Name=mip;
OS Legionella pneumophila.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=446;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 21-30.
RC STRAIN=130b / Wadsworth / Serogroup 1;
RX PubMed=2925252; DOI=10.1128/iai.57.4.1263-1270.1989;
RA Engleberg N.C., Carter C., Weber D.R., Cianciotto N.P., Eisenstein B.I.;
RT "DNA sequence of mip, a Legionella pneumophila gene associated with
RT macrophage infectivity.";
RL Infect. Immun. 57:1263-1270(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 33154 / Togus 1 / Serogroup 2,
RC ATCC 33155 / Bloomington 2 / Serogroup 3,
RC ATCC 33215 / Chicago 2 / Serogroup 6, ATCC 43283 / Leiden 1 / Serogroup 10,
RC ATCC 43290 / Serogroup 12, Edelstein F1480 / Serogroup 9, and
RC Yu 1242 / Serogroup 6;
RX PubMed=11927981; DOI=10.1007/s00284-01-0024-6;
RA Bumbaugh A.C., McGraw E.A., Page K.L., Selander R.K., Whittam T.S.;
RT "Sequence polymorphism of dotA and mip alleles mediating invasion and
RT intracellular replication of Legionella pneumophila.";
RL Curr. Microbiol. 44:314-322(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Chicago / Serogroup 6, Pavia 37 / Serogroup 6, and
RC Trento 36 / Serogroup 6;
RA Castellani Pastoris M., Scaturro M., La Rosa G., Muscillo M., Ricci M.L.;
RT "Genotypic characterization of Legionella species isolated in Italy.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Serogroup 6;
RA Castellani Pastoris M., Scaturro M., La Rosa G., Muscillo M., Ricci M.L.;
RT "Genetic characterization of an avirulent mutant of Legionella pneumophila
RT serogroup 6.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential virulence factor associated with macrophage
CC infectivity. Exhibits PPIase activity.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC ChEBI:CHEBI:83834; EC=5.2.1.8;
CC -!- SUBCELLULAR LOCATION: Cell outer membrane.
CC -!- SIMILARITY: Belongs to the FKBP-type PPIase family. {ECO:0000305}.
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DR EMBL; AF095221; AAF32500.1; -; Genomic_DNA.
DR EMBL; AF095222; AAF32501.1; -; Genomic_DNA.
DR EMBL; AF095223; AAF32502.1; -; Genomic_DNA.
DR EMBL; AF095225; AAF32504.1; -; Genomic_DNA.
DR EMBL; AF095226; AAF32505.1; -; Genomic_DNA.
DR EMBL; AF095227; AAF32506.1; -; Genomic_DNA.
DR EMBL; AF095228; AAF32507.1; -; Genomic_DNA.
DR EMBL; AJ496266; CAD42884.1; -; Genomic_DNA.
DR EMBL; AJ496270; CAD42888.1; -; Genomic_DNA.
DR EMBL; AJ496271; CAD42889.1; -; Genomic_DNA.
DR EMBL; AJ496381; CAD43142.1; -; Genomic_DNA.
DR RefSeq; WP_011214989.1; NZ_QFHM01000013.1.
DR AlphaFoldDB; Q70YI1; -.
DR BMRB; Q70YI1; -.
DR SMR; Q70YI1; -.
DR STRING; 91892.BIZ52_04250; -.
DR BindingDB; Q70YI1; -.
DR ChEMBL; CHEMBL1667669; -.
DR eggNOG; COG0545; Bacteria.
DR OMA; KYMSGHI; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006457; P:protein folding; IEA:InterPro.
DR Gene3D; 1.10.287.460; -; 1.
DR Gene3D; 3.10.50.40; -; 1.
DR InterPro; IPR008104; INFPOTNTIATR.
DR InterPro; IPR046357; PPIase_dom_sf.
DR InterPro; IPR001179; PPIase_FKBP_dom.
DR InterPro; IPR000774; PPIase_FKBP_N.
DR InterPro; IPR036944; PPIase_FKBP_N_sf.
DR Pfam; PF00254; FKBP_C; 1.
DR Pfam; PF01346; FKBP_N; 1.
DR PRINTS; PR01730; INFPOTNTIATR.
DR PROSITE; PS50059; FKBP_PPIASE; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Direct protein sequencing; Isomerase; Membrane;
KW Rotamase; Signal; Virulence.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|PubMed:2925252"
FT CHAIN 21..233
FT /note="Outer membrane protein MIP"
FT /id="PRO_0000025532"
FT DOMAIN 144..233
FT /note="PPIase FKBP-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00277"
SQ SEQUENCE 233 AA; 24865 MW; FE8345428D835323 CRC64;
MKMKLVTAAV MGLAMSTAMA ATDATSLATD KDKLSYSIGA DLGKNFKNQG IDVNPEAMAK
GMQDAMSGAQ LALTEQQMKD VLNKFQKDLM AKRTAEFNKK ADENKVKGEA FLTENKNKPG
VVVLPSGLQY KVINAGNGVK PGKSDTVTVE YTGRLIDGTV FDSTEKTGKP ATFQVSQVIP
GWTEALQLMP AGSTWEIYVP SGLAYGPRSV GGPIGPNETL IFKIHLISVK KSS
