MIRA_EMENI
ID MIRA_EMENI Reviewed; 609 AA.
AC Q8X1Z7; C8VDS1; Q5AV80;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Siderophore iron transporter mirA;
DE AltName: Full=Enterobactin permease;
DE AltName: Full=Major facilitator iron-regulated transporter A;
GN Name=mirA; ORFNames=AN7800;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11555288; DOI=10.1046/j.1365-2958.2001.02586.x;
RA Oberegger H., Schoeser M., Zadra I., Abt B., Haas H.;
RT "SREA is involved in regulation of siderophore biosynthesis, utilization
RT and uptake in Aspergillus nidulans.";
RL Mol. Microbiol. 41:1077-1089(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
RN [4]
RP FUNCTION.
RX PubMed=12487628; DOI=10.1042/bj20021685;
RA Haas H., Schoeser M., Lesuisse E., Ernst J.F., Parson W., Abt B.,
RA Winkelmann G., Oberegger H.;
RT "Characterization of the Aspergillus nidulans transporters for the
RT siderophores enterobactin and triacetylfusarinine C.";
RL Biochem. J. 371:505-513(2003).
CC -!- FUNCTION: Involved in the transport of siderophore enterobactin and so
CC has a role in iron homeostasis. {ECO:0000269|PubMed:12487628}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CBF80133.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAA61588.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY027565; AAK17009.1; -; Genomic_DNA.
DR EMBL; AACD01000132; EAA61588.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BN001304; CBF80133.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_681069.1; XM_675977.1.
DR AlphaFoldDB; Q8X1Z7; -.
DR STRING; 227321.Q8X1Z7; -.
DR EnsemblFungi; EAA61588; EAA61588; AN7800.2.
DR GeneID; 2869707; -.
DR KEGG; ani:AN7800.2; -.
DR VEuPathDB; FungiDB:AN7800; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_012970_1_1_1; -.
DR InParanoid; Q8X1Z7; -.
DR OrthoDB; 641071at2759; -.
DR Proteomes; UP000000560; Chromosome IV.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0042931; F:enterobactin transmembrane transporter activity; IDA:AspGD.
DR GO; GO:0015343; F:siderophore transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR GO; GO:0006826; P:iron ion transport; IMP:AspGD.
DR GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 3: Inferred from homology;
KW Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..609
FT /note="Siderophore iron transporter mirA"
FT /id="PRO_0000084859"
FT TRANSMEM 56..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..141
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..170
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..406
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..432
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..502
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 555..574
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 66311 MW; C3D2521A57C1468B CRC64;
MALDDISAVP KGALDTDPAV ERPPPLLDAD RSDSERLQPG VKRAEMLRKG WTRQGLIIAF
TGLFLATLSI NFGDYSTQVY VPYATSAFKQ HSAMSAARVV GNITRIAAYP IIAKLGDVFG
RAEMFILSIV FQAVGYAIYA GCKNVGQYIA GGIFEAIGST GFGLTQQVFV ADVTNLINRA
VWSTLPDSLT VIPALYLGTE IAEAVLEKNE WRWGFGMWAI IEPVCSVLLV GTMLYYQKRA
RKDPSPAEFA SEPTERNVDD GWWKRIYNLV WVQLDAFGAI LLLLGLSLFL VPLSLTGSGN
SDDWHRGSFI AMLVLGVVIF VAFLAWDTWC AKKPFIPYRM IKNRTVAAAC LLGILDFFHY
SVFSVFFTSY LQVAAHHGAG PATRIDNSLR VAFQVAGIFA AYFMKFTKRS QVWVFTGVPL
CVLGMGVLLY LVDMGEGRVG NEAAFVTAKS LIGIGRGFYQ TASQVSVQAK VSRGEVSVVT
AVFFAAMSIG GAIGTSVAGA IWRSTLPPKL AQHLPAELKD QAQAIFGSIV VAQKYEVGTP
ARDAIDMCYR QSQRMLAIAA LAALAPMLII MFFLENVPLT DETTLIELHG NREAVKKNHS
GGEGKEARS
