MIRB_EMENI
ID MIRB_EMENI Reviewed; 604 AA.
AC Q870L2; C8VEQ8; Q5AT40;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Siderophore iron transporter mirB;
DE AltName: Full=Major facilitator iron-regulated transporter B;
DE AltName: Full=Triacetylfusarinine C permease;
GN Name=mirB; ORFNames=AN8540;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=12487628; DOI=10.1042/bj20021685;
RA Haas H., Schoeser M., Lesuisse E., Ernst J.F., Parson W., Abt B.,
RA Winkelmann G., Oberegger H.;
RT "Characterization of the Aspergillus nidulans transporters for the
RT siderophores enterobactin and triacetylfusarinine C.";
RL Biochem. J. 371:505-513(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Involved in the transport of siderophore triacestylfusarinine
CC C and so has a role in iron homeostasis. {ECO:0000269|PubMed:12487628}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CBF80759.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAA66965.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY131330; AAN10149.1; -; Genomic_DNA.
DR EMBL; AACD01000157; EAA66965.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BN001305; CBF80759.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_681809.1; XM_676717.1.
DR AlphaFoldDB; Q870L2; -.
DR SMR; Q870L2; -.
DR STRING; 227321.Q870L2; -.
DR TCDB; 2.A.1.16.7; the major facilitator superfamily (mfs).
DR EnsemblFungi; EAA66965; EAA66965; AN8540.2.
DR GeneID; 2868677; -.
DR KEGG; ani:AN8540.2; -.
DR VEuPathDB; FungiDB:AN8540; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_012970_1_0_1; -.
DR InParanoid; Q870L2; -.
DR OrthoDB; 641071at2759; -.
DR Proteomes; UP000000560; Chromosome V.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0010106; P:cellular response to iron ion starvation; IEP:AspGD.
DR GO; GO:0015686; P:ferric triacetylfusarinine C import into cell; IDA:AspGD.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 2.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..604
FT /note="Siderophore iron transporter mirB"
FT /id="PRO_0000084860"
FT TRANSMEM 73..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..385
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..422
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..449
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 489..511
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 566..588
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 66217 MW; E3F1D9973550787E CRC64;
MTIGSKFSLL AGTRKTDGPT EISASSPPDV ETPSAEKTAT ASAGNKEVGI NDNSSDEALP
SQHVQTGVQK IQAVTLVWSK WSLVAVFCLL WLVTLANGFR QSILYSLTPY ATSSFQSHSL
LTVINIVSSA MVSALYIPVA KVVDVWGRAE GWLVMVGLST LGLIMMAASK NLETYCAADV
FYSVGFAGMN YILCVLAADI TNLRNRGIAF AFTSSPYMIT AFAGSKAAEK FLVNVNWRWG
FGAFAIIFPF VASPVYFVLK VGLNRAEKQG IIQPRLRSGR TLSQNFKYYF FAFDIPGVIL
LAGGLTVFLL PFTLATRAPN GWKSDYIIAM IVTGFVVMVL FVLYQAYWAP QPFLKYEFLT
NRTVLGACLI DATYQMSYYC WNSYFNSFLQ VVCNLPVAEA GYVGSTFQVV SGVLLFMVGF
AIRKTGYFRW LLFIGVPLYI FAQGLMIHFR QPNQYIGYIV MCEIFISIGG SIFVLLQQLA
VLVAVDHQYV AAALAVLFIS GGIGGAVGNA ISGAIWTNTF LPALMRNLPE SAKANAVAIY
GDLRVQLSYP VNSPERIAIQ ESYGYAQARM LAAGTGLMAL MFIWMFMVKN YNVKNMSQTK
GMVF
