MIRC_EMENI
ID MIRC_EMENI Reviewed; 607 AA.
AC Q870L3; C8VBG2; Q5AW45;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Siderophore iron transporter mirC;
DE AltName: Full=Major facilitator iron-regulated transporter C;
GN Name=mirC; ORFNames=AN7485;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12487628; DOI=10.1042/bj20021685;
RA Haas H., Schoeser M., Lesuisse E., Ernst J.F., Parson W., Abt B.,
RA Winkelmann G., Oberegger H.;
RT "Characterization of the Aspergillus nidulans transporters for the
RT siderophores enterobactin and triacetylfusarinine C.";
RL Biochem. J. 371:505-513(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY135152; AAN08046.1; -; Genomic_DNA.
DR EMBL; AACD01000129; EAA62065.1; -; Genomic_DNA.
DR EMBL; BN001304; CBF79472.1; -; Genomic_DNA.
DR RefSeq; XP_680754.1; XM_675662.1.
DR AlphaFoldDB; Q870L3; -.
DR SMR; Q870L3; -.
DR EnsemblFungi; CBF79472; CBF79472; ANIA_07485.
DR EnsemblFungi; EAA62065; EAA62065; AN7485.2.
DR GeneID; 2869709; -.
DR KEGG; ani:AN7485.2; -.
DR VEuPathDB; FungiDB:AN7485; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_012970_2_0_1; -.
DR InParanoid; Q870L3; -.
DR OMA; CIAVSIY; -.
DR OrthoDB; 641071at2759; -.
DR Proteomes; UP000000560; Chromosome IV.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0015343; F:siderophore transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0010106; P:cellular response to iron ion starvation; IEP:AspGD.
DR GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Ion transport; Iron; Iron transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..607
FT /note="Siderophore iron transporter mirC"
FT /id="PRO_0000084861"
FT TRANSMEM 67..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..368
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..410
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 446..468
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 481..503
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 557..574
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 584..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 607 AA; 66288 MW; 5826FFDD36B1A73A CRC64;
MPLLEPSATA YGTFGDMRPD TEDEGERLLT DGYVSDDDGS AVTSVDSVQE GVRKIEAINI
TWTTRSLVIA YISIFLMAFC TSLEGQTIMS LSAYATSAFS KHSLISTVLV VQNVVNAVIK
PPMAKIADVF GRFEAFCVSI LIYVLGYIQM AASTNVQTYA SAQIFYAAGS TGLQILQQVF
IADSSSLLNR ALLALLPELP FLVTVWIGPT IADVVLENSS WRWGYGMWSI ILPASFLPLA
LSLLLNQRKA KRLNLIKERP HHRRGFVAAV RRTWYDLDIF GLALLSAAVT LILVPLTLAA
NTKNGWKSNS IVAMIVIGVV CLILLPFWET SKKLAPKPLL SLHLLKQRTA LAGCCLAFFY
FMAFYFSVQP YLYSYLQVVQ GYDVATAGRV TQTFAFTSTI AAFGVSILIK YTRRYRVYVT
LGCVIYMTGL LLMLLYRKEG SSPLQVLGTQ VIVGMGGGLL NVPVQLGVQA SASHQEVAAA
TAMFLTSMEM GGAVGAAISG AVWTHNIPRK LNLYLPDEYK SEAGAIFGKL TKALSYEMGT
PVRSAINRSY QETMNKLLVL ALLATLPLIP LSLLMSNYKL DKMSESSDHD DASPRNGLGP
GERAKRT
