ID   MIS12_BOVIN             Reviewed;         206 AA.
AC   Q5EA49;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Protein MIS12 homolog;
GN   Name=MIS12;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the MIS12 complex, which may be fundamental for
CC       kinetochore formation and proper chromosome segregation during mitosis.
CC       Essential for proper kinetochore microtubule attachments.
CC       {ECO:0000250|UniProtKB:Q9H081}.
CC   -!- SUBUNIT: Component of the MIS12 complex composed of MIS12, DSN1, NSL1
CC       and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
CC       {ECO:0000250|UniProtKB:Q9H081}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q9H081}. Note=Associated with the kinetochore.
CC       {ECO:0000250|UniProtKB:Q9H081}.
CC   -!- SIMILARITY: Belongs to the mis12 family. {ECO:0000305}.
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DR   EMBL; BT020720; AAX08737.1; -; mRNA.
DR   EMBL; BC119961; AAI19962.1; -; mRNA.
DR   RefSeq; NP_001070437.1; NM_001076969.1.
DR   RefSeq; XP_010814246.1; XM_010815944.2.
DR   AlphaFoldDB; Q5EA49; -.
DR   SMR; Q5EA49; -.
DR   STRING; 9913.ENSBTAP00000027230; -.
DR   PaxDb; Q5EA49; -.
DR   PRIDE; Q5EA49; -.
DR   Ensembl; ENSBTAT00000027230; ENSBTAP00000027230; ENSBTAG00000020432.
DR   GeneID; 767858; -.
DR   KEGG; bta:767858; -.
DR   CTD; 79003; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020432; -.
DR   VGNC; VGNC:31484; MIS12.
DR   eggNOG; ENOG502RXZ1; Eukaryota.
DR   GeneTree; ENSGT00390000018665; -.
DR   HOGENOM; CLU_097032_0_0_1; -.
DR   InParanoid; Q5EA49; -.
DR   OMA; DYLFEMM; -.
DR   OrthoDB; 1197218at2759; -.
DR   TreeFam; TF101136; -.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000020432; Expressed in corpus epididymis and 104 other tissues.
DR   GO; GO:0000444; C:MIS12/MIND type complex; ISS:UniProtKB.
DR   GO; GO:0000818; C:nuclear MIS12/MIND complex; IBA:GO_Central.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051382; P:kinetochore assembly; IBA:GO_Central.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IBA:GO_Central.
DR   GO; GO:0034501; P:protein localization to kinetochore; IBA:GO_Central.
DR   InterPro; IPR008685; Centromere_Mis12.
DR   PANTHER; PTHR14527; PTHR14527; 1.
DR   Pfam; PF05859; Mis12; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Reference proteome.
FT   CHAIN           1..206
FT                   /note="Protein MIS12 homolog"
FT                   /id="PRO_0000283719"
FT   COILED          108..205
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   206 AA;  24159 MW;  7FC9E25EF4BC8124 CRC64;
     MSVDPMTYEA QFFGFTPQTC MLRIYIAFQD YLFEVMQAVE QVILKKLDGI PDCAISPVEI
     RKCTEKFLCF MKGRFDNLFG KMEQLFLQLI LRIPPNVLLP EDKSQETQSY SEEEFHFLQK
     EIEQLQEKYK TELCTKQALL AELEEQKIVQ AKLKQTLSLF DELENVGRDH GASDFREGLV
     FLIQNSRKLQ NIRENVEKEG KRLKIS