ID   MIS12_CHICK             Reviewed;         210 AA.
AC   Q1T769;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Protein MIS12 homolog;
GN   Name=MIS12;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1] {ECO:0000312|EMBL:BAE93417.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16585270; DOI=10.1083/jcb.200509158;
RA   Kline S.L., Cheeseman I.M., Hori T., Fukagawa T., Desai A.;
RT   "The human Mis12 complex is required for kinetochore assembly and proper
RT   chromosome segregation.";
RL   J. Cell Biol. 173:9-17(2006).
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=21464230; DOI=10.1083/jcb.201012050;
RA   Suzuki A., Hori T., Nishino T., Usukura J., Miyagi A., Morikawa K.,
RA   Fukagawa T.;
RT   "Spindle microtubules generate tension-dependent changes in the
RT   distribution of inner kinetochore proteins.";
RL   J. Cell Biol. 193:125-140(2011).
CC   -!- FUNCTION: Part of the MIS12 complex which is required for normal
CC       chromosome alignment and segregation and for kinetochore formation
CC       during mitosis. Essential for proper kinetochore microtubule
CC       attachments. {ECO:0000250|UniProtKB:Q9H081}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000269|PubMed:21464230}. Note=Localizes to the outer kinetochore
CC       domain of centromeres. {ECO:0000269|PubMed:21464230}.
CC   -!- SIMILARITY: Belongs to the mis12 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB253764; BAE93417.1; -; mRNA.
DR   RefSeq; NP_001038142.1; NM_001044677.1.
DR   AlphaFoldDB; Q1T769; -.
DR   SMR; Q1T769; -.
DR   STRING; 9031.ENSGALP00000002491; -.
DR   PaxDb; Q1T769; -.
DR   GeneID; 693254; -.
DR   KEGG; gga:693254; -.
DR   CTD; 79003; -.
DR   VEuPathDB; HostDB:geneid_693254; -.
DR   eggNOG; ENOG502RXZ1; Eukaryota.
DR   InParanoid; Q1T769; -.
DR   OrthoDB; 1197218at2759; -.
DR   PhylomeDB; Q1T769; -.
DR   PRO; PR:Q1T769; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0000444; C:MIS12/MIND type complex; ISS:UniProtKB.
DR   GO; GO:0000818; C:nuclear MIS12/MIND complex; IBA:GO_Central.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007059; P:chromosome segregation; ISS:UniProtKB.
DR   GO; GO:0051382; P:kinetochore assembly; ISS:UniProtKB.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IBA:GO_Central.
DR   GO; GO:0034501; P:protein localization to kinetochore; IBA:GO_Central.
DR   InterPro; IPR008685; Centromere_Mis12.
DR   PANTHER; PTHR14527; PTHR14527; 1.
DR   Pfam; PF05859; Mis12; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Coiled coil; Kinetochore; Mitosis; Reference proteome.
FT   CHAIN           1..210
FT                   /note="Protein MIS12 homolog"
FT                   /id="PRO_0000248236"
FT   COILED          124..208
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   210 AA;  24691 MW;  B7FA358C9B571F4E CRC64;
     MSVRPMAYET QFFGFTPQTC MLRIYLAFQD YLFEMMVVVE SVILKKLEAL PAVQISRFEI
     RKSTEKFLHF MKARFDQLFE KMEEVLLQLV LSIPDNVLLP EDRVHQQYPY SQEEFCALQD
     EISQLQQQCR AEAAAGQALR AELEEQRAVQ AELEKVVQWF DGLENVCREH GTGNFKESLV
     FLTQNCKKLQ DVLRDVEEKS KKIKKRQQLL