ID   MIS12_PONAB             Reviewed;         205 AA.
AC   Q5R9W0;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Protein MIS12 homolog;
GN   Name=MIS12;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the MIS12 complex which is required for normal
CC       chromosome alignment and segregation and for kinetochore formation
CC       during mitosis. Essential for proper kinetochore microtubule
CC       attachments. {ECO:0000250|UniProtKB:Q9H081}.
CC   -!- SUBUNIT: Component of the MIS12 complex composed of MIS12, DSN1, NSL1
CC       and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
CC       {ECO:0000250|UniProtKB:Q9H081}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q9H081}. Note=Associated with the kinetochore.
CC       {ECO:0000250|UniProtKB:Q9H081}.
CC   -!- SIMILARITY: Belongs to the mis12 family. {ECO:0000305}.
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DR   EMBL; CR859272; CAH91450.1; -; mRNA.
DR   RefSeq; NP_001128987.1; NM_001135515.2.
DR   RefSeq; XP_009249460.1; XM_009251185.1.
DR   RefSeq; XP_009249461.1; XM_009251186.1.
DR   AlphaFoldDB; Q5R9W0; -.
DR   SMR; Q5R9W0; -.
DR   STRING; 9601.ENSPPYP00000008862; -.
DR   Ensembl; ENSPPYT00000009225; ENSPPYP00000008862; ENSPPYG00000007873.
DR   GeneID; 100190827; -.
DR   KEGG; pon:100190827; -.
DR   CTD; 79003; -.
DR   eggNOG; ENOG502RXZ1; Eukaryota.
DR   GeneTree; ENSGT00390000018665; -.
DR   HOGENOM; CLU_097032_0_0_1; -.
DR   InParanoid; Q5R9W0; -.
DR   OMA; DYLFEMM; -.
DR   OrthoDB; 1197218at2759; -.
DR   TreeFam; TF101136; -.
DR   Proteomes; UP000001595; Chromosome 17.
DR   GO; GO:0000444; C:MIS12/MIND type complex; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; ISS:UniProtKB.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0051382; P:kinetochore assembly; IEA:Ensembl.
DR   InterPro; IPR008685; Centromere_Mis12.
DR   PANTHER; PTHR14527; PTHR14527; 1.
DR   Pfam; PF05859; Mis12; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Coiled coil; Kinetochore; Mitosis; Reference proteome.
FT   CHAIN           1..205
FT                   /note="Protein MIS12 homolog"
FT                   /id="PRO_0000297536"
FT   COILED          108..205
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   205 AA;  24140 MW;  8CC906E843D4BD56 CRC64;
     MSVDPMTYEA QFFGFTPQTC MLRIYIAFQD YLFEVMQAVE QVILKKLDGI PDCDISPVQI
     RKCTEKFLCF MKGHFDNLFS KMEQLFLQLI LRIPSNILLP EDKCKETPYS EEDFQHLQKE
     IEQLQEKYKT ELCTKQALLA ELEEQKIVQA KLKQTLTFFD ELHNVGRDHG TSDFRESLVS
     LVQNSRKLQN IRDNVEKESK RLKIS