MIS12_RAT
ID MIS12_RAT Reviewed; 206 AA.
AC Q7TQ72;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Protein MIS12 homolog;
DE AltName: Full=Liver regeneration-related protein LRRG112;
GN Name=Mis12; ORFNames=Ac1585;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RA Xu C.S., Li W.Q., Li Y.C., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y.,
RA Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F.,
RA Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT "Liver regeneration after PH.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the MIS12 complex which is required for normal
CC chromosome alignment and segregation and for kinetochore formation
CC during mitosis. Essential for proper kinetochore microtubule
CC attachments. {ECO:0000250|UniProtKB:Q9H081}.
CC -!- SUBUNIT: Component of the MIS12 complex composed of MIS12, DSN1, NSL1
CC and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.
CC {ECO:0000250|UniProtKB:Q9H081}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000250|UniProtKB:Q9H081}. Note=Associated with the kinetochore.
CC {ECO:0000250|UniProtKB:Q9H081}.
CC -!- SIMILARITY: Belongs to the mis12 family. {ECO:0000305}.
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DR EMBL; AY310159; AAP78767.2; -; mRNA.
DR RefSeq; NP_001041437.1; NM_001047972.1.
DR AlphaFoldDB; Q7TQ72; -.
DR SMR; Q7TQ72; -.
DR STRING; 10116.ENSRNOP00000010144; -.
DR jPOST; Q7TQ72; -.
DR PaxDb; Q7TQ72; -.
DR PRIDE; Q7TQ72; -.
DR GeneID; 501706; -.
DR KEGG; rno:501706; -.
DR UCSC; RGD:1564837; rat.
DR CTD; 79003; -.
DR RGD; 1564837; Mis12.
DR eggNOG; ENOG502RXZ1; Eukaryota.
DR InParanoid; Q7TQ72; -.
DR PhylomeDB; Q7TQ72; -.
DR Reactome; R-RNO-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-RNO-2467813; Separation of Sister Chromatids.
DR Reactome; R-RNO-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-RNO-5663220; RHO GTPases Activate Formins.
DR Reactome; R-RNO-68877; Mitotic Prometaphase.
DR Reactome; R-RNO-9648025; EML4 and NUDC in mitotic spindle formation.
DR PRO; PR:Q7TQ72; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0000776; C:kinetochore; ISO:RGD.
DR GO; GO:0000444; C:MIS12/MIND type complex; ISO:RGD.
DR GO; GO:0000818; C:nuclear MIS12/MIND complex; IBA:GO_Central.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; ISS:UniProtKB.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; ISO:RGD.
DR GO; GO:0051382; P:kinetochore assembly; ISO:RGD.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; IBA:GO_Central.
DR GO; GO:0034501; P:protein localization to kinetochore; IBA:GO_Central.
DR InterPro; IPR008685; Centromere_Mis12.
DR PANTHER; PTHR14527; PTHR14527; 1.
DR Pfam; PF05859; Mis12; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW Coiled coil; Kinetochore; Mitosis; Reference proteome.
FT CHAIN 1..206
FT /note="Protein MIS12 homolog"
FT /id="PRO_0000297537"
FT COILED 105..206
FT /evidence="ECO:0000255"
SQ SEQUENCE 206 AA; 24161 MW; 9FE486C1D88BE20E CRC64;
MSVDPMAYEA QFFGFTPQTC LLRIYIAFQD HLFEVMQAVE QVILKKLEGI PDCEISSIQT
RKCTEKFLCF MKGRFDNLFG KMEQLILQSI LQIPPNILLP EDKCQETNPF SEEKFQLLKQ
EIKELQEKYK VELCTEQALL AELEEQKTVK AKLRETLTFF DELENIGRYQ GTSNFRESLV
SLVQNCRKLQ DIRDNVEKEG KRLETQ