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MIS20_SCHPO
ID   MIS20_SCHPO             Reviewed;         253 AA.
AC   O94682;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=CENP-A recruiting complex protein mis20 {ECO:0000305};
DE   AltName: Full=Eighteen-interacting centromere protein 2 {ECO:0000303|PubMed:24789708};
DE   AltName: Full=Kinetochore protein mis20 {ECO:0000305};
GN   Name=mis20 {ECO:0000303|PubMed:24774534};
GN   Synonyms=eic2 {ECO:0000303|PubMed:24789708}; ORFNames=SPBC776.16;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3]
RP   FUNCTION, IDENTIFICATION IN THE CENP-A RECRUITING COMPLEX, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=24774534; DOI=10.1111/gtc.12152;
RA   Hayashi T., Ebe M., Nagao K., Kokubu A., Sajiki K., Yanagida M.;
RT   "Schizosaccharomyces pombe centromere protein Mis19 links Mis16 and Mis18
RT   to recruit CENP-A through interacting with NMD factors and the SWI/SNF
RT   complex.";
RL   Genes Cells 19:541-554(2014).
RN   [4]
RP   FUNCTION, IDENTIFICATION IN THE CENP-A RECRUITING COMPLEX, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=24789708; DOI=10.1098/rsob.140043;
RA   Subramanian L., Toda N.R., Rappsilber J., Allshire R.C.;
RT   "Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A
RT   assembly.";
RL   Open Biol. 4:140043-140043(2014).
CC   -!- FUNCTION: Component of the CENP-A recruiting complex that ensures the
CC       integrity of mitotic spindles through maintenance of kinetochore
CC       factors mis6/CENP-I and cnp1/CENP-A (PubMed:24774534, PubMed:24789708).
CC       Seems dispensable for proper chromosome segregation (PubMed:24774534).
CC       {ECO:0000269|PubMed:24774534, ECO:0000269|PubMed:24789708}.
CC   -!- SUBUNIT: Component of the CENP-A recruiting complex composed of at
CC       least mis16, mis19, mis19 and mis20 (PubMed:24774534, PubMed:24789708).
CC       {ECO:0000269|PubMed:24774534, ECO:0000269|PubMed:24789708}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole
CC       body {ECO:0000269|PubMed:16823372}. Chromosome, centromere
CC       {ECO:0000269|PubMed:24774534, ECO:0000269|PubMed:24789708}.
CC       Note=Localizes at the centromeres during interphase, but not in mitosis
CC       (PubMed:24774534). {ECO:0000269|PubMed:24774534}.
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DR   EMBL; CU329671; CAA22889.1; -; Genomic_DNA.
DR   PIR; T40687; T40687.
DR   RefSeq; NP_596332.1; NM_001022253.2.
DR   AlphaFoldDB; O94682; -.
DR   SMR; O94682; -.
DR   BioGRID; 277649; 9.
DR   STRING; 4896.SPBC776.16.1; -.
DR   iPTMnet; O94682; -.
DR   PaxDb; O94682; -.
DR   PRIDE; O94682; -.
DR   EnsemblFungi; SPBC776.16.1; SPBC776.16.1:pep; SPBC776.16.
DR   PomBase; SPBC776.16; mis20.
DR   VEuPathDB; FungiDB:SPBC776.16; -.
DR   HOGENOM; CLU_1099038_0_0_1; -.
DR   PRO; PR:O94682; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0098654; C:CENP-A recruiting complex; IDA:PomBase.
DR   GO; GO:0034506; C:chromosome, centromeric core domain; EXP:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005654; C:nucleoplasm; IDA:PomBase.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; NAS:PomBase.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Cytoplasm; Cytoskeleton;
KW   Mitosis; Reference proteome.
FT   CHAIN           1..253
FT                   /note="CENP-A recruiting complex protein mis20"
FT                   /id="PRO_0000304095"
FT   REGION          113..136
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..133
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   253 AA;  28725 MW;  A979AA30FADDBC8A CRC64;
     MLEQSESHAF INNAPKEDRI QVKFEQLFES LPLPLRAEEA LSKLRHDSAR LMILKTSDPT
     LNMSTYSIED SPMGFECLKY NLSDNNKLLS QNNYRLPDYL EEDEIVSYTF SKTGPTTSKN
     KHPSHSNTIR SPPYKVKKES CHTEINNVSN VSTESINVID ASRGYSPYTS VDSLSVSKNR
     SFISLEESAS NQYDAAEAFY FNADSSSPLR KLSPIELPVT PIRRKTPTIN PNSELKRLQT
     FGKLILHKGS RRR
 
 
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