ID   MISP3_HUMAN             Reviewed;         219 AA.
AC   Q96FF7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUN-2014, sequence version 4.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Uncharacterized protein MISP3 {ECO:0000305};
DE   AltName: Full=MISP family member 3 {ECO:0000312|HGNC:HGNC:26963};
GN   Name=MISP3 {ECO:0000312|HGNC:HGNC:26963};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the MISP family. {ECO:0000305}.
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DR   EMBL; AC022098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC011002; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS77246.1; -.
DR   RefSeq; NP_001278220.1; NM_001291291.1.
DR   AlphaFoldDB; Q96FF7; -.
DR   BioGRID; 125235; 3.
DR   STRING; 9606.ENSP00000269720; -.
DR   iPTMnet; Q96FF7; -.
DR   PhosphoSitePlus; Q96FF7; -.
DR   BioMuta; MISP3; -.
DR   DMDM; 172045854; -.
DR   EPD; Q96FF7; -.
DR   jPOST; Q96FF7; -.
DR   MassIVE; Q96FF7; -.
DR   PaxDb; Q96FF7; -.
DR   PeptideAtlas; Q96FF7; -.
DR   PRIDE; Q96FF7; -.
DR   Antibodypedia; 50317; 3 antibodies from 3 providers.
DR   DNASU; 113230; -.
DR   Ensembl; ENST00000587086.3; ENSP00000465157.1; ENSG00000141854.10.
DR   Ensembl; ENST00000672552.1; ENSP00000500884.1; ENSG00000288191.1.
DR   GeneID; 113230; -.
DR   KEGG; hsa:113230; -.
DR   MANE-Select; ENST00000587086.3; ENSP00000465157.1; NM_001291291.2; NP_001278220.1.
DR   UCSC; uc002mxz.4; human.
DR   CTD; 113230; -.
DR   GeneCards; MISP3; -.
DR   HGNC; HGNC:26963; MISP3.
DR   HPA; ENSG00000141854; Low tissue specificity.
DR   neXtProt; NX_Q96FF7; -.
DR   OpenTargets; ENSG00000141854; -.
DR   VEuPathDB; HostDB:ENSG00000141854; -.
DR   eggNOG; ENOG502S5AK; Eukaryota.
DR   GeneTree; ENSGT00940000154739; -.
DR   HOGENOM; CLU_1212229_0_0_1; -.
DR   OMA; PEERFME; -.
DR   OrthoDB; 1380497at2759; -.
DR   PathwayCommons; Q96FF7; -.
DR   SignaLink; Q96FF7; -.
DR   BioGRID-ORCS; 113230; 2 hits in 82 CRISPR screens.
DR   GenomeRNAi; 113230; -.
DR   Pharos; Q96FF7; Tdark.
DR   PRO; PR:Q96FF7; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q96FF7; protein.
DR   Bgee; ENSG00000141854; Expressed in mucosa of transverse colon and 91 other tissues.
DR   ExpressionAtlas; Q96FF7; baseline and differential.
DR   Genevisible; Q96FF7; HS.
DR   InterPro; IPR029304; AKAP2_C.
DR   InterPro; IPR042779; MISP/MISP3.
DR   PANTHER; PTHR18839; PTHR18839; 1.
DR   Pfam; PF15304; AKAP2_C; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..219
FT                   /note="Uncharacterized protein MISP3"
FT                   /id="PRO_0000318963"
FT   REGION          1..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        157..171
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         198
FT                   /note="V -> A (in dbSNP:rs7258963)"
FT                   /id="VAR_039392"
SQ   SEQUENCE   219 AA;  24028 MW;  875DD69E0AE1E654 CRC64;
     METPIEREIR RSCEREESLR RSRGLSPGRA GRELVELRVR PVLNLPGPGP ALPRALERAR
     AGAQMQRDIE REAHRQAALA RPAVPEPRAR SPPQPLGELK RFFEAAAGSG SSAGAGDGAG
     PQRLPEPGGR PRSAVQGGCR VLGSAPPPFT PSLLEQEVRA VREREQELQR QRRSVYGTAE
     FKEPTPSLTA SRGDGKLVVI WPPRRKVSEN GLEQEERKP