MISSL_HUMAN
ID MISSL_HUMAN Reviewed; 245 AA.
AC Q8NDC0; B2RDD8; Q96BG5;
DT 11-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 4.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=MAPK-interacting and spindle-stabilizing protein-like;
DE AltName: Full=Mitogen-activated protein kinase 1-interacting protein 1-like;
GN Name=MAPK1IP1L; Synonyms=C14orf32;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 2-17, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT
RP SER-2, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=T-cell;
RA Bienvenut W.V., Kanor S., Tissot J.-D., Quadroni M.;
RL Submitted (MAY-2006) to UniProtKB.
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007;
RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,
RA Greff Z., Keri G., Stemmann O., Mann M.;
RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the
RT kinome across the cell cycle.";
RL Mol. Cell 31:438-448(2008).
RN [9]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE
RP ANALYSIS] AT SER-15, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE
RP ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [11]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE
RP ANALYSIS] AT SER-15, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE
RP ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-6 AND SER-15, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q8NDC0; Q5VV41: ARHGEF16; NbExp=3; IntAct=EBI-741424, EBI-1057448;
CC Q8NDC0; Q6P1W5: C1orf94; NbExp=5; IntAct=EBI-741424, EBI-946029;
CC Q8NDC0; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-741424, EBI-747776;
CC Q8NDC0; Q15038: DAZAP2; NbExp=3; IntAct=EBI-741424, EBI-724310;
CC Q8NDC0; Q01844: EWSR1; NbExp=5; IntAct=EBI-741424, EBI-739737;
CC Q8NDC0; Q96AE4-2: FUBP1; NbExp=3; IntAct=EBI-741424, EBI-12121668;
CC Q8NDC0; A0A0S2Z4Q4: HGS; NbExp=3; IntAct=EBI-741424, EBI-16429135;
CC Q8NDC0; O14964: HGS; NbExp=6; IntAct=EBI-741424, EBI-740220;
CC Q8NDC0; Q9BUJ2: HNRNPUL1; NbExp=5; IntAct=EBI-741424, EBI-1018153;
CC Q8NDC0; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-741424, EBI-1048945;
CC Q8NDC0; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-741424, EBI-10241353;
CC Q8NDC0; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-741424, EBI-12111050;
CC Q8NDC0; Q96PV6: LENG8; NbExp=5; IntAct=EBI-741424, EBI-739546;
CC Q8NDC0; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-741424, EBI-716006;
CC Q8NDC0; P35548: MSX2; NbExp=3; IntAct=EBI-741424, EBI-6447480;
CC Q8NDC0; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-741424, EBI-744023;
CC Q8NDC0; O43251: RBFOX2; NbExp=3; IntAct=EBI-741424, EBI-746056;
CC Q8NDC0; O75177: SS18L1; NbExp=3; IntAct=EBI-741424, EBI-744674;
CC Q8NDC0; O75177-5: SS18L1; NbExp=3; IntAct=EBI-741424, EBI-12035119;
CC Q8NDC0; P63165: SUMO1; NbExp=3; IntAct=EBI-741424, EBI-80140;
CC Q8NDC0; G2XKQ0: SUMO1P1; NbExp=3; IntAct=EBI-741424, EBI-10175576;
CC Q8NDC0; Q92734: TFG; NbExp=6; IntAct=EBI-741424, EBI-357061;
CC Q8NDC0; Q01085-2: TIAL1; NbExp=3; IntAct=EBI-741424, EBI-11064654;
CC Q8NDC0; Q7KZS0: UBE2I; NbExp=6; IntAct=EBI-741424, EBI-10180829;
CC Q8NDC0; A5D8V6: VPS37C; NbExp=6; IntAct=EBI-741424, EBI-2559305;
CC -!- SIMILARITY: Belongs to the MISS family. {ECO:0000305}.
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DR EMBL; AK315501; BAG37885.1; -; mRNA.
DR EMBL; AL834285; CAD38959.2; -; mRNA.
DR EMBL; AL139316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471061; EAW80657.1; -; Genomic_DNA.
DR EMBL; BC015621; AAH15621.1; -; mRNA.
DR CCDS; CCDS32085.1; -.
DR RefSeq; NP_653179.1; NM_144578.3.
DR AlphaFoldDB; Q8NDC0; -.
DR SMR; Q8NDC0; -.
DR BioGRID; 125030; 41.
DR IntAct; Q8NDC0; 35.
DR STRING; 9606.ENSP00000378851; -.
DR GlyGen; Q8NDC0; 9 sites, 2 O-linked glycans (9 sites).
DR iPTMnet; Q8NDC0; -.
DR PhosphoSitePlus; Q8NDC0; -.
DR BioMuta; MAPK1IP1L; -.
DR EPD; Q8NDC0; -.
DR jPOST; Q8NDC0; -.
DR MassIVE; Q8NDC0; -.
DR MaxQB; Q8NDC0; -.
DR PaxDb; Q8NDC0; -.
DR PeptideAtlas; Q8NDC0; -.
DR PRIDE; Q8NDC0; -.
DR ProteomicsDB; 73012; -.
DR Antibodypedia; 49801; 87 antibodies from 17 providers.
DR DNASU; 93487; -.
DR Ensembl; ENST00000395468.9; ENSP00000378851.3; ENSG00000168175.15.
DR Ensembl; ENST00000622254.1; ENSP00000481882.1; ENSG00000168175.15.
DR GeneID; 93487; -.
DR KEGG; hsa:93487; -.
DR MANE-Select; ENST00000395468.9; ENSP00000378851.3; NM_144578.4; NP_653179.1.
DR UCSC; uc001xbq.2; human.
DR CTD; 93487; -.
DR DisGeNET; 93487; -.
DR GeneCards; MAPK1IP1L; -.
DR HGNC; HGNC:19840; MAPK1IP1L.
DR HPA; ENSG00000168175; Low tissue specificity.
DR neXtProt; NX_Q8NDC0; -.
DR OpenTargets; ENSG00000168175; -.
DR PharmGKB; PA162395015; -.
DR VEuPathDB; HostDB:ENSG00000168175; -.
DR eggNOG; ENOG502RYAB; Eukaryota.
DR GeneTree; ENSGT00730000111340; -.
DR HOGENOM; CLU_063887_0_0_1; -.
DR InParanoid; Q8NDC0; -.
DR OMA; PWNTPSA; -.
DR OrthoDB; 1626851at2759; -.
DR PhylomeDB; Q8NDC0; -.
DR PathwayCommons; Q8NDC0; -.
DR SignaLink; Q8NDC0; -.
DR BioGRID-ORCS; 93487; 19 hits in 1081 CRISPR screens.
DR ChiTaRS; MAPK1IP1L; human.
DR GeneWiki; C14orf32; -.
DR GenomeRNAi; 93487; -.
DR Pharos; Q8NDC0; Tbio.
DR PRO; PR:Q8NDC0; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q8NDC0; protein.
DR Bgee; ENSG00000168175; Expressed in cauda epididymis and 214 other tissues.
DR Genevisible; Q8NDC0; HS.
DR InterPro; IPR031653; MISS.
DR PANTHER; PTHR35973; PTHR35973; 1.
DR Pfam; PF15822; MISS; 1.
PE 1: Evidence at protein level;
KW Acetylation; Direct protein sequencing; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692"
FT CHAIN 2..245
FT /note="MAPK-interacting and spindle-stabilizing protein-
FT like"
FT /id="PRO_0000209890"
FT REGION 1..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..62
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..131
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..238
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 6
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 15
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17081983,
FT ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"
SQ SEQUENCE 245 AA; 24269 MW; 8B03ADFE2581D5C5 CRC64;
MSDEFSLADA LPEHSPAKTS AVSNTKPGQP PQGWPGSNPW NNPSAPSSVP SGLPPSATPS
TVPFGPAPTG MYPSVPPTGP PPGPPAPFPP SGPSCPPPGG PYPAPTVPGP GPTGPYPTPN
MPFPELPRPY GAPTDPAAAG PLGPWGSMSS GPWAPGMGGQ YPTPNMPYPS PGPYPAPPPP
QAPGAAPPVP WGTVPPGAWG PPAPYPAPTG SYPTPGLYPT PSNPFQVPSG PSGAPPMPGG
PHSYH
