ID   6PGL_BOVIN              Reviewed;         258 AA.
AC   Q2TBQ8;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=6-phosphogluconolactonase;
DE            Short=6PGL;
DE            EC=3.1.1.31;
GN   Name=PGLS;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC         + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       2/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC       isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
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DR   EMBL; BC109789; AAI09790.1; -; mRNA.
DR   RefSeq; NP_001033669.1; NM_001038580.1.
DR   AlphaFoldDB; Q2TBQ8; -.
DR   SMR; Q2TBQ8; -.
DR   STRING; 9913.ENSBTAP00000022314; -.
DR   PaxDb; Q2TBQ8; -.
DR   PeptideAtlas; Q2TBQ8; -.
DR   PRIDE; Q2TBQ8; -.
DR   GeneID; 616120; -.
DR   KEGG; bta:616120; -.
DR   CTD; 25796; -.
DR   eggNOG; KOG3147; Eukaryota.
DR   InParanoid; Q2TBQ8; -.
DR   OrthoDB; 1420529at2759; -.
DR   SABIO-RK; Q2TBQ8; -.
DR   UniPathway; UPA00115; UER00409.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR   CDD; cd01400; 6PGL; 1.
DR   InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR   InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR039104; PGLS.
DR   PANTHER; PTHR11054; PTHR11054; 1.
DR   Pfam; PF01182; Glucosamine_iso; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR01198; pgl; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Hydrolase; Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O95336"
FT   CHAIN           2..258
FT                   /note="6-phosphogluconolactonase"
FT                   /id="PRO_0000288666"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:O95336"
FT   MOD_RES         49
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O95336"
FT   MOD_RES         180
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:O95336"
SQ   SEQUENCE   258 AA;  27547 MW;  C6C56548D40C310A CRC64;
     MAAPAPRLIS VFSSPQELGA SLAQLVVQQA ACCLADAGAR FTLGLSGGSL VSMLARELPA
     AAAPAGPASL ARWTLGFCDE RLVPFEHAES TYGLYRTHLL SKLPIFDSQV ITINPALPVE
     EAAEDYAKKL RQAFQGDSIP VFDLLILGVG PDGHTCSLFP DHPLLQEREK IVAPISDSPK
     PPPQRVTLTL PVLNAARTVI YVATGEGKAA ILKRILEDKE ENPLPAALVQ PSAGKLCWFL
     DEAAARLLTV PFEKHSTL