位置:首页 > 蛋白库 > MIS_HUMAN
MIS_HUMAN
ID   MIS_HUMAN               Reviewed;         560 AA.
AC   P03971; O75246; Q6GTN3;
DT   23-OCT-1986, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 3.
DT   03-AUG-2022, entry version 200.
DE   RecName: Full=Muellerian-inhibiting factor;
DE   AltName: Full=Anti-Muellerian hormone;
DE            Short=AMH;
DE   AltName: Full=Muellerian-inhibiting substance {ECO:0000303|PubMed:3754790};
DE            Short=MIS {ECO:0000303|PubMed:3754790};
DE   Flags: Precursor;
GN   Name=AMH {ECO:0000312|HGNC:HGNC:464}; Synonyms=MIF;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-49 AND ALA-515, FUNCTION,
RP   AND SUBCELLULAR LOCATION.
RX   PubMed=3754790; DOI=10.1016/0092-8674(86)90783-x;
RA   Cate R.L., Mattaliano R.J., Hession C., Tizard R., Farber N.M., Cheung A.,
RA   Ninfa E.G., Frey A.Z., Gash D.J., Chow E.P., Fisher R.A., Bertonis J.M.,
RA   Torres G., Wallner B.P., Ramachandran K.L., Ragin R.C., Manganaro T.F.,
RA   McLaughlin D.T., Donahoe P.K.;
RT   "Isolation of the bovine and human genes for Mullerian inhibiting substance
RT   and expression of the human gene in animal cells.";
RL   Cell 45:685-698(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-515.
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PROTEOLYTIC CLEAVAGE, SUBCELLULAR LOCATION, SUBUNIT, AND PROTEIN SEQUENCE
RP   OF 25-34 AND 452-461.
RX   PubMed=2974034; DOI=10.1016/s0021-9258(18)37375-7;
RA   Pepinsky R.B., Sinclair L.K., Chow E.P., Mattaliano R.J., Manganaro T.F.,
RA   Donahoe P.K., Cate R.L.;
RT   "Proteolytic processing of mullerian inhibiting substance produces a
RT   transforming growth factor-beta-like fragment.";
RL   J. Biol. Chem. 263:18961-18964(1988).
RN   [5]
RP   FUNCTION, SUBUNIT, AND PROTEOLYTIC PROCESSING.
RX   PubMed=8469238; DOI=10.1210/mend.7.2.8469238;
RA   Wilson C.A., di Clemente N., Ehrenfels C., Pepinsky R.B., Josso N.,
RA   Vigier B., Cate R.L.;
RT   "Mullerian inhibiting substance requires its N-terminal domain for
RT   maintenance of biological activity, a novel finding within the transforming
RT   growth factor-beta superfamily.";
RL   Mol. Endocrinol. 7:247-257(1993).
RN   [6]
RP   INDUCTION.
RX   PubMed=11779604; DOI=10.1016/s0015-0282(01)02944-2;
RA   Cook C.L., Siow Y., Brenner A.G., Fallat M.E.;
RT   "Relationship between serum muellerian-inhibiting substance and other
RT   reproductive hormones in untreated women with polycystic ovary syndrome and
RT   normal women.";
RL   Fertil. Steril. 77:141-146(2002).
RN   [7]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=14742691; DOI=10.1093/molehr/gah015;
RA   Weenen C., Laven J.S., Von Bergh A.R., Cranfield M., Groome N.P.,
RA   Visser J.A., Kramer P., Fauser B.C., Themmen A.P.;
RT   "Anti-Muellerian hormone expression pattern in the human ovary: potential
RT   implications for initial and cyclic follicle recruitment.";
RL   Mol. Hum. Reprod. 10:77-83(2004).
RN   [8]
RP   FUNCTION, INTERACTION WITH AMHR2, AND PROTEOLYTIC PROCESSING.
RX   PubMed=20861221; DOI=10.1210/me.2010-0273;
RA   di Clemente N., Jamin S.P., Lugovskoy A., Carmillo P., Ehrenfels C.,
RA   Picard J.Y., Whitty A., Josso N., Pepinsky R.B., Cate R.L.;
RT   "Processing of anti-mullerian hormone regulates receptor activation by a
RT   mechanism distinct from TGF-beta.";
RL   Mol. Endocrinol. 24:2193-2206(2010).
RN   [9]
RP   VARIANT ARG-325.
RX   PubMed=1483695; DOI=10.1007/bf00220465;
RA   Carre-Eusebe D., Imbeaud S., Harbison M., New M.I., Josso N., Picard J.-Y.;
RT   "Variants of the anti-Mullerian hormone gene in a compound heterozygote
RT   with the persistent Mullerian duct syndrome and his family.";
RL   Hum. Genet. 90:389-394(1992).
RN   [10]
RP   VARIANTS PMDS1 GLY-12; PRO-70; VAL-101; TRP-123; CYS-167; CYS-194 AND
RP   ALA-477.
RX   PubMed=8162013; DOI=10.1093/hmg/3.1.125;
RA   Imbeaud S., Carre-Eusebe D., Rey R., Belville C., Josso N., Picard J.-Y.;
RT   "Molecular genetics of the persistent Mullerian duct syndrome: a study of
RT   19 families.";
RL   Hum. Mol. Genet. 3:125-131(1994).
RN   [11]
RP   VARIANTS PMDS1 GLN-506 AND TYR-525.
RX   PubMed=8872466; DOI=10.1093/hmg/5.9.1269;
RA   Imbeaud S., Belville C., Messika-Zeitoun L., Rey R., di Clemente N.,
RA   Josso N., Picard J.-Y.;
RT   "A 27 base-pair deletion of the anti-Muellerian type II receptor gene is
RT   the most common cause of the persistent Muellerian duct syndrome.";
RL   Hum. Mol. Genet. 5:1269-1277(1996).
RN   [12]
RP   X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 459-560 IN COMPLEX WITH AMHR2,
RP   DISULFIDE BOND, MUTAGENESIS OF ARG-472; LEU-478; GLU-481; GLN-484; LYS-534;
RP   LEU-535 AND ALA-546, AND FUNCTION.
RX   PubMed=34155118; DOI=10.1073/pnas.2104809118;
RA   Hart K.N., Stocker W.A., Nagykery N.G., Walton K.L., Harrison C.A.,
RA   Donahoe P.K., Pepin D., Thompson T.B.;
RT   "Structure of AMH bound to AMHR2 provides insight into a unique signaling
RT   pair in the TGF-beta family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 118:0-0(2021).
CC   -!- FUNCTION: Plays an important role in several reproductive functions.
CC       Induces Muellerian duct regression during male fetal sexual
CC       differentiation (PubMed:3754790, PubMed:34155118, PubMed:8469238). Also
CC       plays a role in Leydig cell differentiation and function (By
CC       similarity). In female acts as a negative regulator of the primordial
CC       to primary follicle transition and decreases FSH sensitivity of growing
CC       follicles (PubMed:14742691). AMH signals by binding to a specific type-
CC       II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1
CC       and BMPR1A), and recruiting SMAD proteins that are translocated to the
CC       nucleus to regulate target gene expression (PubMed:20861221,
CC       PubMed:34155118). {ECO:0000250|UniProtKB:P27106,
CC       ECO:0000269|PubMed:14742691, ECO:0000269|PubMed:20861221,
CC       ECO:0000269|PubMed:34155118, ECO:0000269|PubMed:3754790,
CC       ECO:0000269|PubMed:8469238}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000269|PubMed:2974034,
CC       ECO:0000269|PubMed:8469238}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2974034,
CC       ECO:0000269|PubMed:3754790}.
CC   -!- TISSUE SPECIFICITY: In ovaries, AMH is detected in granulosa cells of
CC       early growing follicles. {ECO:0000269|PubMed:14742691}.
CC   -!- DEVELOPMENTAL STAGE: Detected in primary follicles and continued to be
CC       expressed in follicles in the antral stage. The highest level of AMH
CC       expression is present in granulosa cells of secondary, preantral and
CC       small antral follicles <4 mm in diameter, whereas expression is lost
CC       from follicles at sizes >8 mm. {ECO:0000269|PubMed:14742691}.
CC   -!- INDUCTION: Plasma AMH levels in polycystic ovary syndrome (PCOS)
CC       patients are two- to threefold higher than in women with normal
CC       ovaries. {ECO:0000269|PubMed:11779604}.
CC   -!- PTM: Preproprotein is proteolytically processed to generate N- and C-
CC       terminal cleavage products that homodimerize and associate to form a
CC       biologically active non-covalent complex (PubMed:8469238,
CC       PubMed:2974034). Binding of the non-covalent complex to AMHR2 induces
CC       dissociation of the pro-region from the mature C-terminal dimer
CC       (PubMed:20861221). The N-terminal portion of the protein, despite
CC       having no intrinsic activity, has the role of amplifying the activity
CC       of the C-terminus (PubMed:20861221, PubMed:8469238).
CC       {ECO:0000269|PubMed:20861221, ECO:0000269|PubMed:2974034,
CC       ECO:0000269|PubMed:8469238}.
CC   -!- DISEASE: Persistent Muellerian duct syndrome 1 (PMDS1) [MIM:261550]: A
CC       form of male pseudohermaphroditism characterized by a failure of
CC       Muellerian duct regression in otherwise normal males.
CC       {ECO:0000269|PubMed:8162013, ECO:0000269|PubMed:8872466}. Note=The
CC       disease is caused by variants affecting the gene represented in this
CC       entry.
CC   -!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Anti-Mullerian hormone entry;
CC       URL="https://en.wikipedia.org/wiki/Anti-m%C3%BCllerian_hormone";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; K03474; AAA98805.1; -; Genomic_DNA.
DR   EMBL; AC005263; AAC25614.1; -; Genomic_DNA.
DR   EMBL; BC049194; AAH49194.1; -; mRNA.
DR   CCDS; CCDS12085.1; -.
DR   PIR; A01397; WFHUM.
DR   RefSeq; NP_000470.2; NM_000479.4.
DR   PDB; 7L0J; X-ray; 2.60 A; A=459-560.
DR   PDBsum; 7L0J; -.
DR   AlphaFoldDB; P03971; -.
DR   SMR; P03971; -.
DR   BioGRID; 106765; 8.
DR   IntAct; P03971; 4.
DR   STRING; 9606.ENSP00000221496; -.
DR   GlyGen; P03971; 4 sites, 1 O-linked glycan (2 sites).
DR   iPTMnet; P03971; -.
DR   PhosphoSitePlus; P03971; -.
DR   BioMuta; AMH; -.
DR   DMDM; 313104218; -.
DR   jPOST; P03971; -.
DR   MassIVE; P03971; -.
DR   MaxQB; P03971; -.
DR   PaxDb; P03971; -.
DR   PeptideAtlas; P03971; -.
DR   PRIDE; P03971; -.
DR   ProteomicsDB; 51624; -.
DR   Antibodypedia; 22968; 548 antibodies from 32 providers.
DR   DNASU; 268; -.
DR   Ensembl; ENST00000221496.5; ENSP00000221496.2; ENSG00000104899.8.
DR   GeneID; 268; -.
DR   KEGG; hsa:268; -.
DR   MANE-Select; ENST00000221496.5; ENSP00000221496.2; NM_000479.5; NP_000470.3.
DR   UCSC; uc002lvh.3; human.
DR   CTD; 268; -.
DR   DisGeNET; 268; -.
DR   GeneCards; AMH; -.
DR   HGNC; HGNC:464; AMH.
DR   HPA; ENSG00000104899; Group enriched (pituitary gland, testis).
DR   MalaCards; AMH; -.
DR   MIM; 261550; phenotype.
DR   MIM; 600957; gene.
DR   neXtProt; NX_P03971; -.
DR   OpenTargets; ENSG00000104899; -.
DR   Orphanet; 2856; Persistent Muellerian duct syndrome.
DR   PharmGKB; PA24769; -.
DR   VEuPathDB; HostDB:ENSG00000104899; -.
DR   eggNOG; KOG3900; Eukaryota.
DR   GeneTree; ENSGT00390000006337; -.
DR   HOGENOM; CLU_025681_1_0_1; -.
DR   InParanoid; P03971; -.
DR   OMA; DPAPLHD; -.
DR   OrthoDB; 516965at2759; -.
DR   PhylomeDB; P03971; -.
DR   TreeFam; TF335595; -.
DR   PathwayCommons; P03971; -.
DR   Reactome; R-HSA-201451; Signaling by BMP.
DR   Reactome; R-HSA-9690406; Transcriptional regulation of testis differentiation.
DR   SignaLink; P03971; -.
DR   SIGNOR; P03971; -.
DR   BioGRID-ORCS; 268; 12 hits in 1072 CRISPR screens.
DR   GenomeRNAi; 268; -.
DR   Pharos; P03971; Tbio.
DR   PRO; PR:P03971; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; P03971; protein.
DR   Bgee; ENSG00000104899; Expressed in right hemisphere of cerebellum and 92 other tissues.
DR   Genevisible; P03971; HS.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0005179; F:hormone activity; TAS:ProtInc.
DR   GO; GO:0005102; F:signaling receptor binding; IPI:UniProtKB.
DR   GO; GO:0005114; F:type II transforming growth factor beta receptor binding; IDA:UniProtKB.
DR   GO; GO:0007568; P:aging; IEA:Ensembl.
DR   GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR   GO; GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.
DR   GO; GO:0033327; P:Leydig cell differentiation; ISS:UniProtKB.
DR   GO; GO:0001880; P:Mullerian duct regression; IDA:UniProtKB.
DR   GO; GO:2000355; P:negative regulation of ovarian follicle development; ISS:UniProtKB.
DR   GO; GO:0001541; P:ovarian follicle development; ISS:UniProtKB.
DR   GO; GO:0060389; P:pathway-restricted SMAD protein phosphorylation; IDA:UniProtKB.
DR   GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR   GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Ensembl.
DR   GO; GO:0001546; P:preantral ovarian follicle growth; IEA:Ensembl.
DR   GO; GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0007530; P:sex determination; TAS:ProtInc.
DR   GO; GO:0007548; P:sex differentiation; TAS:UniProtKB.
DR   GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR006799; AMH_N.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR021203; Muellerian-inhibiting_factor.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR15009; PTHR15009; 1.
DR   Pfam; PF04709; AMH_N; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   PIRSF; PIRSF037270; Muellerian-inhibiting_factor; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Differentiation; Direct protein sequencing; Disease variant;
KW   Disulfide bond; Glycoprotein; Gonadal differentiation; Growth factor;
KW   Pseudohermaphroditism; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000269|PubMed:2974034"
FT   PROPEP          25..451
FT                   /evidence="ECO:0000269|PubMed:2974034"
FT                   /id="PRO_0000454649"
FT   CHAIN           452..560
FT                   /note="Muellerian-inhibiting factor"
FT                   /id="PRO_0000033747"
FT   REGION          259..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..280
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            451..452
FT                   /note="Cleavage"
FT                   /evidence="ECO:0000269|PubMed:2974034"
FT   CARBOHYD        64
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        329
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        462..526
FT                   /evidence="ECO:0000269|PubMed:34155118,
FT                   ECO:0007744|PDB:7L0J"
FT   DISULFID        488..557
FT                   /evidence="ECO:0000269|PubMed:34155118,
FT                   ECO:0007744|PDB:7L0J"
FT   DISULFID        492..559
FT                   /evidence="ECO:0000269|PubMed:34155118,
FT                   ECO:0007744|PDB:7L0J"
FT   DISULFID        525
FT                   /note="Interchain"
FT                   /evidence="ECO:0000269|PubMed:34155118"
FT   VARIANT         12
FT                   /note="V -> G (in PMDS1; dbSNP:rs149082963)"
FT                   /evidence="ECO:0000269|PubMed:8162013"
FT                   /id="VAR_007483"
FT   VARIANT         49
FT                   /note="S -> I (in dbSNP:rs10407022)"
FT                   /evidence="ECO:0000269|PubMed:3754790"
FT                   /id="VAR_007484"
FT   VARIANT         70
FT                   /note="L -> P (in PMDS1)"
FT                   /evidence="ECO:0000269|PubMed:8162013"
FT                   /id="VAR_007485"
FT   VARIANT         101
FT                   /note="G -> V (in PMDS1)"
FT                   /evidence="ECO:0000269|PubMed:8162013"
FT                   /id="VAR_007486"
FT   VARIANT         123
FT                   /note="R -> W (in PMDS1; dbSNP:rs569914235)"
FT                   /evidence="ECO:0000269|PubMed:8162013"
FT                   /id="VAR_007487"
FT   VARIANT         167
FT                   /note="Y -> C (in PMDS1; dbSNP:rs371874189)"
FT                   /evidence="ECO:0000269|PubMed:8162013"
FT                   /id="VAR_007488"
FT   VARIANT         185
FT                   /note="Q -> E (in dbSNP:rs200523942)"
FT                   /id="VAR_007489"
FT   VARIANT         194
FT                   /note="R -> C (in PMDS1; dbSNP:rs777003373)"
FT                   /evidence="ECO:0000269|PubMed:8162013"
FT                   /id="VAR_007490"
FT   VARIANT         325
FT                   /note="Q -> R (in dbSNP:rs140765565)"
FT                   /evidence="ECO:0000269|PubMed:1483695"
FT                   /id="VAR_007491"
FT   VARIANT         477
FT                   /note="V -> A (in PMDS1; dbSNP:rs1358787117)"
FT                   /evidence="ECO:0000269|PubMed:8162013"
FT                   /id="VAR_007492"
FT   VARIANT         506
FT                   /note="H -> Q (in PMDS1; dbSNP:rs138571039)"
FT                   /evidence="ECO:0000269|PubMed:8872466"
FT                   /id="VAR_031027"
FT   VARIANT         515
FT                   /note="V -> A (in dbSNP:rs10417628)"
FT                   /evidence="ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|PubMed:3754790"
FT                   /id="VAR_065100"
FT   VARIANT         525
FT                   /note="C -> Y (in PMDS1)"
FT                   /evidence="ECO:0000269|PubMed:8872466"
FT                   /id="VAR_031028"
FT   MUTAGEN         472
FT                   /note="R->D: Little effect on AMH signaling."
FT                   /evidence="ECO:0000269|PubMed:34155118"
FT   MUTAGEN         478
FT                   /note="L->A: Abolishes AMH signaling. Does not induce
FT                   regression of the Muellerian duct."
FT                   /evidence="ECO:0000269|PubMed:34155118"
FT   MUTAGEN         481
FT                   /note="E->A: Shows a slight decrease in AMH signaling.
FT                   Affects slightly Mullerian duct regression."
FT                   /evidence="ECO:0000269|PubMed:34155118"
FT   MUTAGEN         481
FT                   /note="E->R,Y: Decreases AMH signaling."
FT                   /evidence="ECO:0000269|PubMed:34155118"
FT   MUTAGEN         484
FT                   /note="Q->S: Little effect on AMH signaling."
FT                   /evidence="ECO:0000269|PubMed:34155118"
FT   MUTAGEN         534
FT                   /note="K->A: Abolishes AMH signaling."
FT                   /evidence="ECO:0000269|PubMed:34155118"
FT   MUTAGEN         535
FT                   /note="L->Y: Little effect on AMH signaling."
FT                   /evidence="ECO:0000269|PubMed:34155118"
FT   MUTAGEN         546
FT                   /note="A->M: Abolishes AMH signaling."
FT                   /evidence="ECO:0000269|PubMed:34155118"
FT   STRAND          461..465
FT                   /evidence="ECO:0007829|PDB:7L0J"
FT   STRAND          468..470
FT                   /evidence="ECO:0007829|PDB:7L0J"
FT   STRAND          472..479
FT                   /evidence="ECO:0007829|PDB:7L0J"
FT   STRAND          481..484
FT                   /evidence="ECO:0007829|PDB:7L0J"
FT   STRAND          487..491
FT                   /evidence="ECO:0007829|PDB:7L0J"
FT   STRAND          498..500
FT                   /evidence="ECO:0007829|PDB:7L0J"
FT   HELIX           505..515
FT                   /evidence="ECO:0007829|PDB:7L0J"
FT   STRAND          525..540
FT                   /evidence="ECO:0007829|PDB:7L0J"
FT   STRAND          543..560
FT                   /evidence="ECO:0007829|PDB:7L0J"
SQ   SEQUENCE   560 AA;  59195 MW;  D05DCEE4FEDF94C2 CRC64;
     MRDLPLTSLA LVLSALGALL GTEALRAEEP AVGTSGLIFR EDLDWPPGSP QEPLCLVALG
     GDSNGSSSPL RVVGALSAYE QAFLGAVQRA RWGPRDLATF GVCNTGDRQA ALPSLRRLGA
     WLRDPGGQRL VVLHLEEVTW EPTPSLRFQE PPPGGAGPPE LALLVLYPGP GPEVTVTRAG
     LPGAQSLCPS RDTRYLVLAV DRPAGAWRGS GLALTLQPRG EDSRLSTARL QALLFGDDHR
     CFTRMTPALL LLPRSEPAPL PAHGQLDTVP FPPPRPSAEL EESPPSADPF LETLTRLVRA
     LRVPPARASA PRLALDPDAL AGFPQGLVNL SDPAALERLL DGEEPLLLLL RPTAATTGDP
     APLHDPTSAP WATALARRVA AELQAAAAEL RSLPGLPPAT APLLARLLAL CPGGPGGLGD
     PLRALLLLKA LQGLRVEWRG RDPRGPGRAQ RSAGATAADG PCALRELSVD LRAERSVLIP
     ETYQANNCQG VCGWPQSDRN PRYGNHVVLL LKMQVRGAAL ARPPCCVPTA YAGKLLISLS
     EERISAHHVP NMVATECGCR
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024