ID   MIT1_YEAST              Reviewed;         666 AA.
AC   P40002; D3DLP0;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Transcriptional regulator MIT1;
GN   Name=MIT1; OrderedLocusNames=YEL007W;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169868;
RA   Dietrich F.S., Mulligan J.T., Hennessy K.M., Yelton M.A., Allen E.,
RA   Araujo R., Aviles E., Berno A., Brennan T., Carpenter J., Chen E.,
RA   Cherry J.M., Chung E., Duncan M., Guzman E., Hartzell G., Hunicke-Smith S.,
RA   Hyman R.W., Kayser A., Komp C., Lashkari D., Lew H., Lin D., Mosedale D.,
RA   Nakahara K., Namath A., Norgren R., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Sehl P., Schramm S., Shogren T., Smith V., Taylor P., Wei Y.,
RA   Botstein D., Davis R.W.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome V.";
RL   Nature 387:78-81(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA   Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT   "A multidimensional chromatography technology for in-depth phosphoproteome
RT   analysis.";
RL   Mol. Cell. Proteomics 7:1389-1396(2008).
RN   [6]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-152, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19779198; DOI=10.1126/science.1172867;
RA   Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT   "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT   into evolution.";
RL   Science 325:1682-1686(2009).
RN   [7]
RP   FUNCTION, AND DNA-BINDING.
RX   PubMed=22095082; DOI=10.1534/genetics.111.134080;
RA   Cain C.W., Lohse M.B., Homann O.R., Sil A., Johnson A.D.;
RT   "A conserved transcriptional regulator governs fungal morphology in widely
RT   diverged species.";
RL   Genetics 190:511-521(2012).
CC   -!- FUNCTION: Transcriptional regulator of pseudohyphal growth.
CC       {ECO:0000269|PubMed:22095082}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC       {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 1710 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the MIT1/WOR1 family. {ECO:0000305}.
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DR   EMBL; U18530; AAB64484.1; -; Genomic_DNA.
DR   EMBL; BK006939; DAA07644.1; -; Genomic_DNA.
DR   PIR; S50452; S50452.
DR   RefSeq; NP_010909.1; NM_001178822.1.
DR   AlphaFoldDB; P40002; -.
DR   SMR; P40002; -.
DR   BioGRID; 36724; 151.
DR   IntAct; P40002; 5.
DR   STRING; 4932.YEL007W; -.
DR   iPTMnet; P40002; -.
DR   MaxQB; P40002; -.
DR   PaxDb; P40002; -.
DR   PRIDE; P40002; -.
DR   EnsemblFungi; YEL007W_mRNA; YEL007W; YEL007W.
DR   GeneID; 856711; -.
DR   KEGG; sce:YEL007W; -.
DR   SGD; S000000733; MIT1.
DR   VEuPathDB; FungiDB:YEL007W; -.
DR   eggNOG; KOG4476; Eukaryota.
DR   GeneTree; ENSGT00940000176779; -.
DR   HOGENOM; CLU_404467_0_0_1; -.
DR   InParanoid; P40002; -.
DR   BioCyc; YEAST:G3O-30136-MON; -.
DR   PRO; PR:P40002; -.
DR   Proteomes; UP000002311; Chromosome V.
DR   RNAct; P40002; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005634; C:nucleus; HDA:SGD.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   InterPro; IPR018608; Gti1/Pac2.
DR   PANTHER; PTHR28027; PTHR28027; 1.
DR   Pfam; PF09729; Gti1_Pac2; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..666
FT                   /note="Transcriptional regulator MIT1"
FT                   /id="PRO_0000202617"
FT   REGION          90..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          314..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          425..479
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          528..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..157
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         152
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19779198"
SQ   SEQUENCE   666 AA;  72534 MW;  DC36F887BF2D17E0 CRC64;
     MDIEPTFKGY IEDEDDALLI LQATLDGKLK HIPRRPYEIE RPYLIVSGSI FVFIEEISGI
     KRWTDGVSWS PSRISGKFLI YKELDKENAG SNANATSSGS TDSAVITDGT SGARNNPSSS
     KIKLPPLKNH QFDLPPTMGH SSFESEQDTS ISPSNRSNLP LKYTGLVKKT ISVKLKRPPF
     NSIENLHIVS YYSVKDIKQN CLVTPKASPF LKDVRPSQEL IVAMGNTTLG NVKNNSTTTG
     NGPNNINNKS NSSTPLNTVI STNNNSANIN AAGSNQFTSA NKNYYYKNDE SSGYPITQFA
     PALPSTTLMY TANPPYITQS PDNTNATGMN THVNNNNNNS NNSSNSNNSN NNNNNNNNNN
     NNNNNNINNI NNVNTNAGNG NNPNRFHNAS FAYNTTGDFI NPQQQGQISY PFYYTTIPIN
     NPNYYTTQPP NPVTNASTNE NQGYSTSSTQ HPYYGHPTES QSASAAAGAT GTPGTAENVL
     PVSSMQPLLH QANNNSASSA TSTAPYPVYS MNVNVPYYNS SASAYKRAQE NTTSNTNAEP
     SGATSTNSGT MLSNPAYANS QYTPSQVYYQ GFPQYAMASA QNPSMYQHQH QHPLPTVYPI
     ATPQQNIMSS GHTLSTIGSD PQHHHYQQEP NDHKNFAMGH ANNNILNITN NDTMNNLNTN
     TSTTTQ