MITOK_BOVIN
ID MITOK_BOVIN Reviewed; 404 AA.
AC Q5E9Q3; A6QQF9; Q5E9W7; Q5EA69;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Mitochondrial potassium channel {ECO:0000250|UniProtKB:Q3URS9};
DE Short=MITOK {ECO:0000250|UniProtKB:Q3URS9};
DE AltName: Full=Coiled-coil domain-containing protein 51;
DE Flags: Precursor;
GN Name=CCDC51 {ECO:0000250|UniProtKB:Q3URS9};
GN Synonyms=Mitok {ECO:0000250|UniProtKB:Q3URS9};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial potassium channel located in the mitochondrial
CC inner membrane. Together with ABCB8/MITOSUR, forms a protein complex
CC localized in the mitochondria that mediates ATP-dependent potassium
CC currents across the inner membrane (that is, mitoK(ATP) channel). May
CC contribute to the homeostatic control of cellular metabolism under
CC stress conditions by regulating the mitochondrial matrix volume.
CC {ECO:0000250|UniProtKB:Q3URS9}.
CC -!- ACTIVITY REGULATION: Channel activity inhibited by ATP via
CC ABCB8/MITOSUR subunit. {ECO:0000250|UniProtKB:Q96ER9}.
CC -!- SUBUNIT: The mitochondrial potassium channel (mitoK(ATP)) forms a
CC heteromultimer. {ECO:0000250|UniProtKB:Q3URS9}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q3URS9}; Multi-pass membrane protein
CC {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BT020661; AAX08678.1; -; mRNA.
DR EMBL; BT020700; AAX08717.1; -; mRNA.
DR EMBL; BT020802; AAX08819.1; -; mRNA.
DR EMBL; BT020803; AAX08820.1; -; mRNA.
DR EMBL; BT020853; AAX08870.1; -; mRNA.
DR EMBL; BT020867; AAX08884.1; -; mRNA.
DR EMBL; BC149811; AAI49812.1; -; mRNA.
DR RefSeq; NP_001015619.1; NM_001015619.1.
DR RefSeq; XP_005222886.1; XM_005222829.3.
DR RefSeq; XP_005222887.1; XM_005222830.3.
DR RefSeq; XP_005222888.1; XM_005222831.3.
DR RefSeq; XP_010816031.1; XM_010817729.2.
DR AlphaFoldDB; Q5E9Q3; -.
DR SMR; Q5E9Q3; -.
DR STRING; 9913.ENSBTAP00000017844; -.
DR PaxDb; Q5E9Q3; -.
DR PRIDE; Q5E9Q3; -.
DR Ensembl; ENSBTAT00000017844; ENSBTAP00000017844; ENSBTAG00000013413.
DR Ensembl; ENSBTAT00000069946; ENSBTAP00000058493; ENSBTAG00000013413.
DR GeneID; 517515; -.
DR KEGG; bta:517515; -.
DR CTD; 79714; -.
DR VEuPathDB; HostDB:ENSBTAG00000013413; -.
DR VGNC; VGNC:26899; CCDC51.
DR eggNOG; ENOG502QWCS; Eukaryota.
DR GeneTree; ENSGT00390000001709; -.
DR HOGENOM; CLU_060968_0_0_1; -.
DR InParanoid; Q5E9Q3; -.
DR OMA; STATTWW; -.
DR OrthoDB; 1459041at2759; -.
DR TreeFam; TF318449; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000013413; Expressed in digestive system secreted substance and 103 other tissues.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0062157; C:mitochondrial ATP-gated potassium channel complex; ISS:UniProtKB.
DR GO; GO:0062156; F:mitochondrial ATP-gated potassium channel activity; ISS:UniProtKB.
DR GO; GO:0006884; P:cell volume homeostasis; IEA:Ensembl.
DR GO; GO:0140141; P:mitochondrial potassium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0071805; P:potassium ion transmembrane transport; ISS:UniProtKB.
DR InterPro; IPR037660; CCDC51.
DR PANTHER; PTHR28624; PTHR28624; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Ion channel; Ion transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Phosphoprotein; Potassium; Potassium channel;
KW Potassium transport; Reference proteome; Transit peptide; Transmembrane;
KW Transmembrane helix; Transport.
FT TRANSIT 1..30
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 31..404
FT /note="Mitochondrial potassium channel"
FT /evidence="ECO:0000250|UniProtKB:Q3URS9"
FT /id="PRO_0000288867"
FT TOPO_DOM 31..196
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:Q3URS9"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..380
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000250|UniProtKB:Q3URS9"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 402..404
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000250|UniProtKB:Q3URS9"
FT COILED 111..138
FT /evidence="ECO:0000255"
FT MOD_RES 65
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96ER9"
FT CONFLICT 166
FT /note="A -> S (in Ref. 1; AAX08820)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="F -> L (in Ref. 1; AAX08820)"
FT /evidence="ECO:0000305"
FT CONFLICT 389
FT /note="T -> M (in Ref. 1; AAX08678/AAX08717/AAX08819)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 404 AA; 44985 MW; E47930601B97FB9C CRC64;
MTGRSRVLAM RHVGGVSPVL VRRDLFLTRT LCSHGPSQPR EKRPEEVALG LYHRLTALGA
ALGHSIRQRA SSTAKTWWDR YEEFVGLNEV REAQGNVTEA EKVFMVARGL VREAREDLES
QQTKLKEVRD RLDRISRDDN QYLELATLEH RMLQEEKRLR MTYLRAEDSE REKFSLFSAA
VRESHEKERT RAERTKNWSL IGSVLGALIG VAGSTYVNRV RLQELKALLL EAQKGPVSLQ
EAIREQASSY SLQQRDLRDL VADLKGLVQA GTGQGSLSQA GSSPTQDRDT DVLSAALREQ
LSHSRQVRSR LEGLREQLDG LEKTVSQVAG VVQLAKAAAH PGLESADGAL PGSLLEQGSM
IMALSDTEQR LEAQVNRNTV YGTLVTCATF VAVLPVLYML FRAS
