MIX23_HUMAN
ID MIX23_HUMAN Reviewed; 144 AA.
AC Q4VC31; Q32LY6;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Protein MIX23 {ECO:0000305};
DE AltName: Full=Coiled-coil domain-containing protein 58;
GN Name=MIX23 {ECO:0000312|HGNC:HGNC:31136};
GN Synonyms=CCDC58 {ECO:0000312|HGNC:HGNC:31136};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [3]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-100, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19608861; DOI=10.1126/science.1175371;
RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA Olsen J.V., Mann M.;
RT "Lysine acetylation targets protein complexes and co-regulates major
RT cellular functions.";
RL Science 325:834-840(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [5]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- SIMILARITY: Belongs to the MIX23 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC062725; AAH62725.1; -; mRNA.
DR EMBL; BC109378; AAI09379.1; -; mRNA.
DR CCDS; CCDS33838.1; -.
DR RefSeq; NP_001017928.1; NM_001017928.3.
DR RefSeq; NP_001295255.1; NM_001308326.1.
DR AlphaFoldDB; Q4VC31; -.
DR SMR; Q4VC31; -.
DR BioGRID; 126270; 33.
DR IntAct; Q4VC31; 23.
DR MINT; Q4VC31; -.
DR STRING; 9606.ENSP00000291458; -.
DR CarbonylDB; Q4VC31; -.
DR GlyGen; Q4VC31; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q4VC31; -.
DR PhosphoSitePlus; Q4VC31; -.
DR BioMuta; CCDC58; -.
DR DMDM; 74754617; -.
DR EPD; Q4VC31; -.
DR jPOST; Q4VC31; -.
DR MassIVE; Q4VC31; -.
DR MaxQB; Q4VC31; -.
DR PaxDb; Q4VC31; -.
DR PeptideAtlas; Q4VC31; -.
DR PRIDE; Q4VC31; -.
DR ProteomicsDB; 62300; -.
DR TopDownProteomics; Q4VC31; -.
DR Antibodypedia; 58352; 46 antibodies from 8 providers.
DR DNASU; 131076; -.
DR Ensembl; ENST00000291458.9; ENSP00000291458.5; ENSG00000160124.9.
DR GeneID; 131076; -.
DR KEGG; hsa:131076; -.
DR MANE-Select; ENST00000291458.9; ENSP00000291458.5; NM_001017928.4; NP_001017928.1.
DR UCSC; uc003eey.4; human.
DR CTD; 131076; -.
DR DisGeNET; 131076; -.
DR GeneCards; MIX23; -.
DR HGNC; HGNC:31136; MIX23.
DR HPA; ENSG00000160124; Low tissue specificity.
DR neXtProt; NX_Q4VC31; -.
DR OpenTargets; ENSG00000160124; -.
DR VEuPathDB; HostDB:ENSG00000160124; -.
DR eggNOG; KOG4613; Eukaryota.
DR GeneTree; ENSGT00390000011053; -.
DR InParanoid; Q4VC31; -.
DR OMA; CRYFEPP; -.
DR OrthoDB; 1574254at2759; -.
DR PhylomeDB; Q4VC31; -.
DR TreeFam; TF324875; -.
DR PathwayCommons; Q4VC31; -.
DR SignaLink; Q4VC31; -.
DR BioGRID-ORCS; 131076; 173 hits in 1006 CRISPR screens.
DR ChiTaRS; CCDC58; human.
DR GenomeRNAi; 131076; -.
DR Pharos; Q4VC31; Tdark.
DR PRO; PR:Q4VC31; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q4VC31; protein.
DR Bgee; ENSG00000160124; Expressed in buccal mucosa cell and 171 other tissues.
DR ExpressionAtlas; Q4VC31; baseline and differential.
DR Genevisible; Q4VC31; HS.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR InterPro; IPR019171; MIX23.
DR PANTHER; PTHR31905; PTHR31905; 1.
DR Pfam; PF09774; Cid2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:19413330,
FT ECO:0007744|PubMed:25944712"
FT CHAIN 2..144
FT /note="Protein MIX23"
FT /id="PRO_0000239441"
FT COILED 82..120
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:19413330,
FT ECO:0007744|PubMed:25944712"
FT MOD_RES 100
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:19608861"
FT CONFLICT 4..5
FT /note="PS -> GG (in Ref. 1; AAI09379)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 144 AA; 16620 MW; A78EE047DDD458C8 CRC64;
MAAPSGGVNC EEFAEFQELL KVMRTIDDRI VHELNTTVPT ASFAGKIDAS QTCKQLYESL
MAAHASRDRV IKNCIAQTSA VVKNLREERE KNLDDLTLLK QLRKEQTKLK WMQSELNVEE
VVNDRSWKVF NERCRIHFKP PKNE
