MIX23_MOUSE
ID MIX23_MOUSE Reviewed; 144 AA.
AC Q8R3Q6; Q3UXM5;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Protein MIX23 {ECO:0000305};
DE AltName: Full=Coiled-coil domain-containing protein 58;
GN Name=Mix23 {ECO:0000312|MGI:MGI:2146423};
GN Synonyms=Ccdc58 {ECO:0000312|MGI:MGI:2146423};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Muellerian duct;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Pancreas, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the MIX23 family. {ECO:0000305}.
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DR EMBL; AK135450; BAE22538.1; -; mRNA.
DR EMBL; BC024862; AAH24862.1; -; mRNA.
DR CCDS; CCDS28147.1; -.
DR RefSeq; NP_001152893.1; NM_001159421.1.
DR RefSeq; NP_001152894.1; NM_001159422.1.
DR RefSeq; NP_941047.1; NM_198645.2.
DR AlphaFoldDB; Q8R3Q6; -.
DR SMR; Q8R3Q6; -.
DR STRING; 10090.ENSMUSP00000125874; -.
DR iPTMnet; Q8R3Q6; -.
DR PhosphoSitePlus; Q8R3Q6; -.
DR EPD; Q8R3Q6; -.
DR jPOST; Q8R3Q6; -.
DR MaxQB; Q8R3Q6; -.
DR PaxDb; Q8R3Q6; -.
DR PRIDE; Q8R3Q6; -.
DR ProteomicsDB; 283732; -.
DR Antibodypedia; 58352; 46 antibodies from 8 providers.
DR Ensembl; ENSMUST00000164916; ENSMUSP00000125874; ENSMUSG00000075229.
DR GeneID; 381045; -.
DR KEGG; mmu:381045; -.
DR UCSC; uc007zce.2; mouse.
DR CTD; 381045; -.
DR MGI; MGI:2146423; Ccdc58.
DR VEuPathDB; HostDB:ENSMUSG00000075229; -.
DR eggNOG; KOG4613; Eukaryota.
DR GeneTree; ENSGT00390000011053; -.
DR HOGENOM; CLU_123941_0_0_1; -.
DR InParanoid; Q8R3Q6; -.
DR OMA; CRYFEPP; -.
DR OrthoDB; 1574254at2759; -.
DR PhylomeDB; Q8R3Q6; -.
DR TreeFam; TF324875; -.
DR BioGRID-ORCS; 381045; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Ccdc58; mouse.
DR PRO; PR:Q8R3Q6; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8R3Q6; protein.
DR Bgee; ENSMUSG00000075229; Expressed in yolk sac and 258 other tissues.
DR ExpressionAtlas; Q8R3Q6; baseline and differential.
DR Genevisible; Q8R3Q6; MM.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR InterPro; IPR019171; MIX23.
DR PANTHER; PTHR31905; PTHR31905; 1.
DR Pfam; PF09774; Cid2; 1.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q4VC31"
FT CHAIN 2..144
FT /note="Protein MIX23"
FT /id="PRO_0000239442"
FT COILED 82..120
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q4VC31"
FT MOD_RES 100
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q4VC31"
FT CONFLICT 42
FT /note="S -> C (in Ref. 1; BAE22538)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 144 AA; 16665 MW; 0BF1363A905667D6 CRC64;
MAAPSGSVNC EEFAEFQELL KVMRTIDDRI VHELNTTVPT ASFAGKIDAS QTCKQLYESL
MAAHVSRDRV IKNCIAQTSA VVKSLREERE KNLDDLTLLK RLRKEQTKLK WMQSELNVEE
VVNDRSWKVF NERCRVHFKP PKNE
