ID   MIX2_XENLA              Reviewed;         369 AA.
AC   Q91685;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Homeobox protein Mix.2;
GN   Name=mix-b; Synonyms=mix2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8660890; DOI=10.1006/dbio.1996.0158;
RA   Vize P.D.;
RT   "DNA sequences mediating the transcriptional response of the Mix.2 homeobox
RT   gene to mesoderm induction.";
RL   Dev. Biol. 177:226-231(1996).
CC   -!- FUNCTION: May be a transcription factor which play a regulatory role in
CC       the development of the embryo. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: By activin and TGF-beta1 (immediate early response gene).
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; U50745; AAC60020.1; -; mRNA.
DR   RefSeq; NP_001081094.1; NM_001087625.1.
DR   AlphaFoldDB; Q91685; -.
DR   SMR; Q91685; -.
DR   GeneID; 394379; -.
DR   KEGG; xla:394379; -.
DR   CTD; 394379; -.
DR   Xenbase; XB-GENE-6254430; mix1.L.
DR   OrthoDB; 1270742at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 394379; Expressed in gastrula and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..369
FT                   /note="Homeobox protein Mix.2"
FT                   /id="PRO_0000049194"
FT   DNA_BIND        94..153
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          39..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          153..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..194
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   369 AA;  41537 MW;  FC02182C85D6B9F5 CRC64;
     MNGFSQQLED FYPSYFSPSP LGFSEPEVQP VAMNLVPTIQ KDIQQQPNRK EVTKIPRASE
     QSPVQNVRPK EAINTKEADS RNPEPDSSLV SASQRRKRTF FTQAQLDILE QFFQTNMYPD
     IHHREELARH IYIPESRIQV WFQNRRAKVR RQGAKATKPA LASHHYSSTS GAMFPSAPAP
     NSSSYQMTSS RAQVQPPKEY QLNKFHQSQG FLSYPDSSSD VSRQRFLLSQ ATPGVYHLPQ
     ASSNVYDQNV KSNDPLWGQQ QVYTNMESVL NLSRRPQQMP AQPMFMNSFQ TNKIIKSKMD
     TTSPPIPVST TSSHHSQMSL FAGQDPCHMS TAPGGTYGQI SPISDSGVSD TSPEPSSDWE
     ENVSVLLHL