MIXL1_CHICK
ID MIXL1_CHICK Reviewed; 210 AA.
AC O73592; O73910;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Homeobox protein MIXL1;
DE AltName: Full=Homeodomain protein MIX;
DE Short=cMIX;
DE AltName: Full=MIX1 homeobox-like protein 1;
DE AltName: Full=Mix.1 homeobox-like protein;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 56-210 (ISOFORM 2), AND DEVELOPMENTAL STAGE.
RC TISSUE=Hensens node;
RX PubMed=9739135; DOI=10.1016/s0925-4773(98)00088-4;
RA Stein S., Roeser T., Kessel M.;
RT "CMIX, a paired-type homeobox gene expressed before and during formation of
RT the avian primitive streak.";
RL Mech. Dev. 75:163-165(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND DEVELOPMENTAL STAGE.
RC STRAIN=White leghorn;
RX PubMed=9739137; DOI=10.1016/s0925-4773(98)00089-6;
RA Peale F.V. Jr., Sugden L., Bothwell M.;
RT "Characterization of CMIX, a chicken homeobox gene related to the Xenopus
RT gene mix.1.";
RL Mech. Dev. 75:167-170(1998).
CC -!- FUNCTION: Transcription factor that play a central role in proper axial
CC mesendoderm morphogenesis and endoderm formation. Required for
CC efficient differentiation of cells from the primitive streak stage to
CC blood (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O73592-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O73592-2; Sequence=VSP_029524;
CC -!- DEVELOPMENTAL STAGE: Expressed early in embryogenis in a sickle-shaped
CC area in the posterior zone of the blastoderm. With the beginning of
CC gastrulation, it is found in the primitive streak primordium, then in
CC the young and medium-sized streak, however not in the mesoderm after
CC its emergence. In the fully-extended streak, it is restricted to its
CC middle, i.e. the prospective ventral mesoderm. It is then undetectable
CC by in later stages. {ECO:0000269|PubMed:9739135,
CC ECO:0000269|PubMed:9739137}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ004903; CAA06203.1; -; mRNA.
DR EMBL; U34615; AAC36453.1; -; mRNA.
DR RefSeq; NP_990321.1; NM_204990.1. [O73592-1]
DR AlphaFoldDB; O73592; -.
DR SMR; O73592; -.
DR PaxDb; O73592; -.
DR GeneID; 395838; -.
DR KEGG; gga:395838; -.
DR CTD; 83881; -.
DR VEuPathDB; HostDB:geneid_395838; -.
DR OrthoDB; 1270742at2759; -.
DR PhylomeDB; O73592; -.
DR PRO; PR:O73592; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; Differentiation; DNA-binding;
KW Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..210
FT /note="Homeobox protein MIXL1"
FT /id="PRO_0000311335"
FT DNA_BIND 58..117
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..137
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 116..210
FT /note="QRGPPRPGAPAPPPPPPQRSPCGAAPLLRAREEHREWPPRAAGPPGSALRPH
FT GGSGGAPAGPYPPRPAFPLPAGGGFSELGTEWEENAIGAFRAL -> RRLLGAGNGVGG
FT ERHRRLPSPLTAGRPCPRLFALYPVDCAYLCTGDGGGCAGCRHRVTLFTASI (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:9739135"
FT /id="VSP_029524"
SQ SEQUENCE 210 AA; 21981 MW; F8A4617E2385B5A9 CRC64;
MAALRFGPPP AELPAVPPSC PPGRWLCGTA GGSGGGPGAA PAPLASLPPA AEGAPSAQRR
KRTSFTAAQL ETLELVFQDT MYPDIYLRER LADATQIPES RIQVWFQNRR AKSRRQRGPP
RPGAPAPPPP PPQRSPCGAA PLLRAREEHR EWPPRAAGPP GSALRPHGGS GGAPAGPYPP
RPAFPLPAGG GFSELGTEWE ENAIGAFRAL
