ID   MIY4B_HUMAN             Reviewed;         460 AA.
AC   A8MYZ0; A0A1W2PQ44;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 3.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B;
DE   AltName: Full=Protein FAM188B2;
GN   Name=MINDY4B {ECO:0000312|HGNC:HGNC:35475}; Synonyms=C3orf76, FAM188B2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
CC   -!- SIMILARITY: Belongs to the MINDY deubiquitinase family. FAM188
CC       subfamily. {ECO:0000305}.
CC   -!- CAUTION: In contrast to other members of the MINDY family, lacks the
CC       conserved active sites required for deubiquitination. {ECO:0000305}.
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DR   EMBL; AC016142; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC020636; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108674; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A8MYZ0; -.
DR   PhosphoSitePlus; A8MYZ0; -.
DR   BioMuta; MINDY4B; -.
DR   EPD; A8MYZ0; -.
DR   PaxDb; A8MYZ0; -.
DR   PeptideAtlas; A8MYZ0; -.
DR   PRIDE; A8MYZ0; -.
DR   Antibodypedia; 56512; 8 antibodies from 5 providers.
DR   Ensembl; ENST00000465419.7; ENSP00000491923.1; ENSG00000214237.11.
DR   MANE-Select; ENST00000465419.7; ENSP00000491923.1; NM_001351281.2; NP_001338210.2.
DR   GeneCards; MINDY4B; -.
DR   HGNC; HGNC:35475; MINDY4B.
DR   HPA; ENSG00000214237; Tissue enhanced (brain).
DR   neXtProt; NX_A8MYZ0; -.
DR   OpenTargets; ENSG00000214237; -.
DR   PharmGKB; PA165697258; -.
DR   VEuPathDB; HostDB:ENSG00000214237; -.
DR   GeneTree; ENSGT00940000162644; -.
DR   InParanoid; A8MYZ0; -.
DR   OMA; TRKGKDC; -.
DR   PhylomeDB; A8MYZ0; -.
DR   Pharos; A8MYZ0; Tdark.
DR   PRO; PR:A8MYZ0; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; A8MYZ0; protein.
DR   Bgee; ENSG00000214237; Expressed in nucleus accumbens and 48 other tissues.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   GO; GO:1990380; F:Lys48-specific deubiquitinase activity; IBA:GO_Central.
DR   InterPro; IPR025257; MINDY-3/4_CD.
DR   InterPro; IPR039785; MINY3/4.
DR   PANTHER; PTHR12473; PTHR12473; 1.
DR   Pfam; PF13898; DUF4205; 1.
DR   SMART; SM01174; DUF4205; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..460
FT                   /note="Inactive ubiquitin carboxyl-terminal hydrolase
FT                   MINDY-4B"
FT                   /id="PRO_0000343573"
FT   REGION          41..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   460 AA;  51976 MW;  01C819A64DC43DB0 CRC64;
     MDMEVLGQEQ SSEQLDLEEI SRKISFLDKW REIFSYHRLG TNNSTPQNHE GNHTSADENE
     DGTGLSQPKG QGHLPSSGLC SIPNPSIISS KLGGFPISLA MATKLRQILF GNTVHVFSYN
     WKKAYFRFHD PSSELAFTLE VGKGGARSIQ MAVQGSIIKY LLFTRKGKDC NLGNLCEISK
     KEQEQALAAA LAGILWAAGA AQKATICLVT EDIYVASTPD YSVDNFTERL QLFEFLEKEA
     AEKFIYDHLL CFRGEGSHGV ILFLYSLIFS RTFERLQMDL DVTTTQLLQP NAGGFLCRQA
     VLNMILTGRA SPNVFNGCEE GKSQETLHGV LTRSDVGYLQ WGKDASEDDR LSQVGSMLKT
     PKLPIWLCNI NGNYSILFCT NRQLLSDWKM ERLFDLYFYS GQPSQKKLVR LTIDTHSHHW
     ERDQQEEKHG PRRRFSPVEM AIRTKWSEAT INWNGTVPFF