MIZ1_ARATH
ID MIZ1_ARATH Reviewed; 297 AA.
AC O22227; Q8LB38;
DT 24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Protein MIZU-KUSSEI 1;
GN Name=MIZ1; OrderedLocusNames=At2g41660; ORFNames=T32G6.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF
RP GLY-235.
RX PubMed=17360591; DOI=10.1073/pnas.0609929104;
RA Kobayashi A., Takahashi A., Kakimoto Y., Miyazawa Y., Fujii N.,
RA Higashitani A., Takahashi H.;
RT "A gene essential for hydrotropism in roots.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:4724-4729(2007).
RN [8]
RP FUNCTION.
RX PubMed=21940997; DOI=10.1104/pp.111.186270;
RA Moriwaki T., Miyazawa Y., Kobayashi A., Uchida M., Watanabe C., Fujii N.,
RA Takahashi H.;
RT "Hormonal regulation of lateral root development in Arabidopsis modulated
RT by MIZ1 and requirement of GNOM activity for MIZ1 function.";
RL Plant Physiol. 157:1209-1220(2011).
RN [9]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MUTAGENESIS OF
RP GLY-235.
RX PubMed=22285304; DOI=10.1016/j.febslet.2012.01.008;
RA Yamazaki T., Miyazawa Y., Kobayashi A., Moriwaki T., Fujii N.,
RA Takahashi H.;
RT "MIZ1, an essential protein for root hydrotropism, is associated with the
RT cytoplasmic face of the endoplasmic reticulum membrane in Arabidopsis root
RT cells.";
RL FEBS Lett. 586:398-402(2012).
RN [10]
RP FUNCTION.
RX PubMed=23012350; DOI=10.1093/pcp/pcs129;
RA Miyazawa Y., Moriwaki T., Uchida M., Kobayashi A., Fujii N., Takahashi H.;
RT "Overexpression of MIZU-KUSSEI1 enhances the root hydrotropic response by
RT retaining cell viability under hydrostimulated conditions in Arabidopsis
RT thaliana.";
RL Plant Cell Physiol. 53:1926-1933(2012).
RN [11]
RP FUNCTION, AND INDUCTION.
RX PubMed=22321255; DOI=10.1111/j.1365-3040.2012.02493.x;
RA Moriwaki T., Miyazawa Y., Fujii N., Takahashi H.;
RT "Light and abscisic acid signalling are integrated by MIZ1 gene expression
RT and regulate hydrotropic response in roots of Arabidopsis thaliana.";
RL Plant Cell Environ. 35:1359-1368(2012).
CC -!- FUNCTION: Plays a role in lateral root development by maintaining auxin
CC levels. This function requires GNOM (GN/MIZ2) activity. Negatively
CC regulates cytokinin sensitivity on root development. Positively
CC regulates hydrotropism in roots. {ECO:0000269|PubMed:17360591,
CC ECO:0000269|PubMed:21940997, ECO:0000269|PubMed:22285304,
CC ECO:0000269|PubMed:22321255, ECO:0000269|PubMed:23012350}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:22285304}. Note=Soluble protein associated with the
CC ER.
CC -!- TISSUE SPECIFICITY: Expressed in root meristematic region, cortical
CC cells, lateral root cap cells, columella cells of the root cap, mature
CC region of the roots and leaf hydathodes. {ECO:0000269|PubMed:17360591,
CC ECO:0000269|PubMed:22285304}.
CC -!- INDUCTION: By light and abscisic acid (ABA) in roots.
CC {ECO:0000269|PubMed:22321255}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC conditions, but mutant plants are impaired in hydrotropic response.
CC {ECO:0000269|PubMed:17360591}.
CC -!- MISCELLANEOUS: The Japanese words 'mizu' and 'kussei' means water and
CC tropism, respectively (PubMed:17360591). Plants over-expressing MIZ1 in
CC roots have a reduced number of lateral roots formed, however this
CC defect is recovered with the application of auxin (PubMed:21940997).
CC {ECO:0000305|PubMed:17360591, ECO:0000305|PubMed:21940997}.
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DR EMBL; AC002510; AAB84348.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC10013.1; -; Genomic_DNA.
DR EMBL; AF345340; AAK31144.1; -; mRNA.
DR EMBL; AK227967; BAE99934.1; -; mRNA.
DR EMBL; BT026058; ABG48414.1; -; mRNA.
DR EMBL; AY087440; AAM64986.1; -; mRNA.
DR PIR; T00822; T00822.
DR RefSeq; NP_565953.1; NM_129729.3.
DR AlphaFoldDB; O22227; -.
DR STRING; 3702.AT2G41660.1; -.
DR PaxDb; O22227; -.
DR PRIDE; O22227; -.
DR ProteomicsDB; 237116; -.
DR EnsemblPlants; AT2G41660.1; AT2G41660.1; AT2G41660.
DR GeneID; 818764; -.
DR Gramene; AT2G41660.1; AT2G41660.1; AT2G41660.
DR KEGG; ath:AT2G41660; -.
DR Araport; AT2G41660; -.
DR TAIR; locus:2062647; AT2G41660.
DR eggNOG; ENOG502QU42; Eukaryota.
DR HOGENOM; CLU_057026_0_0_1; -.
DR InParanoid; O22227; -.
DR OMA; PTCRWLN; -.
DR OrthoDB; 1136023at2759; -.
DR PhylomeDB; O22227; -.
DR PRO; PR:O22227; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O22227; baseline and differential.
DR Genevisible; O22227; AT.
DR GO; GO:0032541; C:cortical endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:TAIR.
DR GO; GO:0016020; C:membrane; IDA:TAIR.
DR GO; GO:0009658; P:chloroplast organization; IMP:TAIR.
DR GO; GO:0010274; P:hydrotropism; IMP:UniProtKB.
DR InterPro; IPR006460; MIZ1-like_pln.
DR PANTHER; PTHR31696; PTHR31696; 1.
DR Pfam; PF04759; DUF617; 1.
DR TIGRFAMs; TIGR01570; A_thal_3588; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Membrane; Reference proteome.
FT CHAIN 1..297
FT /note="Protein MIZU-KUSSEI 1"
FT /id="PRO_0000423017"
FT MUTAGEN 235
FT /note="G->E: In miz1; defects in hydrotropic response."
FT /evidence="ECO:0000269|PubMed:17360591,
FT ECO:0000269|PubMed:22285304"
FT CONFLICT 150
FT /note="R -> S (in Ref. 6; AAM64986)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 297 AA; 32510 MW; 12D2561C01FC503C CRC64;
MVPYQELTLQ RSFSYNSRKI NPVTSPARSS HVRSPSSSAL IPSIPEHELF LVPCRRCSYV
PLSSSSSASH NIGKFHLKFS LLLRSFINII NIPACKMLSL PSPPSSSSSV SNQLISLVTG
GSSSLGRRVT GTLYGHKRGH VTFSVQYNQR SDPVLLLDLA MSTATLVKEM SSGLVRIALE
CEKRHRSGTK LFQEPKWTMY CNGRKCGYAV SRGGACTDTD WRVLNTVSRV TVGAGVIPTP
KTIDDVSGVG SGTELGELLY MRGKFERVVG SRDSEAFYMM NPDKNGGPEL SIFLLRI
