ID   MJK2_METJA              Reviewed;         343 AA.
AC   Q58752;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Probable potassium channel protein 2;
DE   AltName: Full=MjK2;
GN   OrderedLocusNames=MJ1357;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
RN   [2]
RP   FUNCTION.
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=12860407; DOI=10.1016/s0014-5793(03)00706-3;
RA   Hellmer J., Zeilinger C.;
RT   "MjK1, a K+ channel from M. jannaschii, mediates K+ uptake and K+
RT   sensitivity in E. coli.";
RL   FEBS Lett. 547:165-169(2003).
CC   -!- FUNCTION: Probable potassium channel protein.
CC       {ECO:0000269|PubMed:12860407}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; L77117; AAB99365.1; -; Genomic_DNA.
DR   PIR; D64469; D64469.
DR   RefSeq; WP_010870874.1; NC_000909.1.
DR   AlphaFoldDB; Q58752; -.
DR   SMR; Q58752; -.
DR   TCDB; 1.A.1.13.10; the voltage-gated ion channel (vic) superfamily.
DR   PRIDE; Q58752; -.
DR   EnsemblBacteria; AAB99365; AAB99365; MJ_1357.
DR   GeneID; 1452259; -.
DR   KEGG; mja:MJ_1357; -.
DR   eggNOG; arCOG01958; Archaea.
DR   HOGENOM; CLU_050982_0_1_2; -.
DR   InParanoid; Q58752; -.
DR   OMA; HIIVCGC; -.
DR   OrthoDB; 80000at2157; -.
DR   PhylomeDB; Q58752; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005267; F:potassium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.1450; -; 1.
DR   InterPro; IPR013099; K_chnl_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   InterPro; IPR003148; RCK_N.
DR   Pfam; PF07885; Ion_trans_2; 1.
DR   Pfam; PF02080; TrkA_C; 1.
DR   Pfam; PF02254; TrkA_N; 1.
DR   SUPFAM; SSF116726; SSF116726; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51202; RCK_C; 1.
DR   PROSITE; PS51201; RCK_N; 1.
PE   4: Predicted;
KW   Cell membrane; Ion channel; Ion transport; Membrane; Potassium;
KW   Potassium channel; Potassium transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..343
FT                   /note="Probable potassium channel protein 2"
FT                   /id="PRO_0000054100"
FT   TOPO_DOM        1..7
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..61
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        83..343
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          109..234
FT                   /note="RCK N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00543"
FT   DOMAIN          253..338
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00544"
FT   MOTIF           46..51
FT                   /note="Selectivity filter"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   343 AA;  38884 MW;  61231B0C001B54C4 CRC64;
     METSKKLVIV AVLSITLILT YAYLISIIEG VDYFTALYFS VITITTTGYG DFTPKTFLGR
     TLTVVYLCVG VGIVMYLFSL IAEFIVEGKF EEFVRLKKMK NKIKTLKDHY IICGYGRLGK
     VVGEKFIEEN IPFIAIDINE DVLKEEYEKY PDKFLYIVGD AKKEEVLKKA KIDKAKGLIA
     TLPSDADNVF LTLTARELNP NILITAKADE KEAIRKLKIA GANRVVSPYL IGGLRMAEVS
     VRPGILDFLS TFIKIAKDEY EEDIELRKFV IEKDSELAYK SLKDANIRGK TGATILGIRR
     EKEFCINPYP EFILKPGDVI YAFGTEENLK YLENLVKKKK KKL