ID   MK67I_DANRE             Reviewed;         269 AA.
AC   Q8JIY8; Q6IQ65;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=MKI67 FHA domain-interacting nucleolar phosphoprotein;
DE   AltName: Full=Nucleolar phosphoprotein NOPP34-like protein;
GN   Name=nifk; Synonyms=mki67ip, mki67ipl;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   TISSUE=Embryo;
RX   PubMed=12006978; DOI=10.1038/ng896;
RA   Golling G., Amsterdam A., Sun Z., Antonelli M., Maldonado E., Chen W.,
RA   Burgess S., Haldi M., Artzt K., Farrington S., Lin S.-Y., Nissen R.M.,
RA   Hopkins N.;
RT   "Insertional mutagenesis in zebrafish rapidly identifies genes essential
RT   for early vertebrate development.";
RL   Nat. Genet. 31:135-140(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an essential role in early embryonic development.
CC       {ECO:0000269|PubMed:12006978}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Embryos have various defects including smaller
CC       heads and eyes. {ECO:0000269|PubMed:12006978}.
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DR   EMBL; AF506200; AAM34644.1; -; mRNA.
DR   EMBL; BC071545; AAH71545.1; -; mRNA.
DR   RefSeq; NP_775395.1; NM_173288.1.
DR   AlphaFoldDB; Q8JIY8; -.
DR   SMR; Q8JIY8; -.
DR   STRING; 7955.ENSDARP00000059548; -.
DR   PaxDb; Q8JIY8; -.
DR   Ensembl; ENSDART00000059549; ENSDARP00000059548; ENSDARG00000040666.
DR   GeneID; 317644; -.
DR   KEGG; dre:317644; -.
DR   CTD; 84365; -.
DR   ZFIN; ZDB-GENE-021231-4; nifk.
DR   eggNOG; KOG4208; Eukaryota.
DR   GeneTree; ENSGT00390000011515; -.
DR   HOGENOM; CLU_025741_1_0_1; -.
DR   InParanoid; Q8JIY8; -.
DR   OMA; GSQRMFR; -.
DR   OrthoDB; 1513142at2759; -.
DR   PhylomeDB; Q8JIY8; -.
DR   TreeFam; TF315137; -.
DR   PRO; PR:Q8JIY8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000040666; Expressed in gastrula and 30 other tissues.
DR   ExpressionAtlas; Q8JIY8; baseline.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR021043; NIFK_FHA_Ki67-binding.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF12196; hNIFK_binding; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..269
FT                   /note="MKI67 FHA domain-interacting nucleolar
FT                   phosphoprotein"
FT                   /id="PRO_0000081631"
FT   DOMAIN          45..123
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          234..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        248..269
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        243
FT                   /note="L -> V (in Ref. 1; AAM34644)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   269 AA;  30099 MW;  6C2DFF9D82AA83FB CRC64;
     MTEGKSSDKP AKRLLALNPK EDAEFQKKVQ QVKKRPQTGQ TLSPGVLYVG HLPRGLFEPQ
     LKSYFEQFGK VLRLRVSRSK KTGGSKGYGF VEFECDEVAK IVAETMNNYL MGERIIKCHV
     IPPEKVHEKL FVGSIAGFKK PKYPAVTRYN KTHTEDDVKK VGTKLLSKES KLRKRLAAKG
     IDYDFPGFAA QIPAKKAPSE ANVSVCSEDV TPVCTPSLLE RRKSLRVEDD DVDDEIVIKV
     KPLPENSDDV EESEEESAEE DEGEEEEAA